| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,105,743 | 184,267,000 | 10.22% | ||
| 2 | FEDERATED HERMES, INC. | 12,461,400 | 175,207,000 | 9.72% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 10,869,860 | 152,830,000 | 8.48% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 9,036,933 | 127,059,000 | 7.05% | ||
| 5 | VANGUARD GROUP INC | 6,281,961 | 88,324,000 | 4.90% | ||
| 6 | BAKER BROS. ADVISORS LP | 6,157,789 | 86,579,000 | 4.80% | ||
| 7 | BlackRock Fund Advisors | 5,079,758 | 71,421,000 | 3.96% | ||
| 8 | RA CAPITAL MANAGEMENT, L.P. | 4,945,697 | 69,536,000 | 3.86% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 3,858,749 | 54,254,000 | 3.01% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 3,417,981 | 48,057,000 | 2.67% | ||
| 11 | D. E. Shaw & Co., Inc. | 3,391,942 | 47,691,000 | 2.65% | ||
| 12 | STATE STREET CORP | 3,335,062 | 46,892,000 | 2.60% | ||
| 13 | RTW INVESTMENTS, LP | 2,131,808 | 29,973,000 | 1.66% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,931,200 | 27,153,000 | 1.51% | ||
| 15 | JENNISON ASSOCIATES LLC | 1,921,305 | 27,014,000 | 1.50% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 1,852,000 | 26,039,000 | 1.44% | ||
| 17 | WELLINGTON MANAGEMENT GROUP LLP | 1,755,567 | 24,683,000 | 1.37% | ||
| 18 | NORTHERN TRUST CORP | 1,523,271 | 21,418,000 | 1.19% | ||
| 19 | Cormorant Asset Management, LP | 1,500,000 | 21,090,000 | 1.17% | ||
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 1,330,400 | 18,705,000 | 1.04% | ||
| 21 | BLACKROCK ADVISORS LLC | 1,244,936 | 17,504,000 | 0.97% | ||
| 22 | Invesco Ltd. | 1,127,371 | 15,851,000 | 0.88% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,076,874 | 15,141,000 | 0.84% | ||
| 24 | NORGES BANK | 1,056,404 | 14,853,000 | 0.82% | ||
| 25 | VHCP Management, LLC | 1,000,659 | 14,069,000 | 0.78% | ||
| 26 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 14,060,000 | 0.78% | ||
| 27 | DEERFIELD MANAGEMENT COMPANY, L.P. | 982,745 | 13,817,000 | 0.77% | ||
| 28 | TEACHERS ADVISORS, LLC | 926,993 | 13,034,000 | 0.72% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 883,608 | 12,423,000 | 0.69% | ||
| 30 | Bank of New York Mellon Corp | 822,147 | 11,560,000 | 0.64% | ||
| 31 | QVT Financial LP | 813,666 | 11,440,000 | 0.63% | ||
| 32 | TWO SIGMA ADVISERS, LP | 797,138 | 11,208,000 | 0.62% | ||
| 33 | Asset Management One Co., Ltd. | 775,889 | 11,118,000 | 0.62% | ||
| 34 | FRANKLIN RESOURCES INC | 777,500 | 10,932,000 | 0.61% | ||
| 35 | BROWN ADVISORY INC | 729,271 | 10,253,000 | 0.57% | ||
| 36 | MORGAN STANLEY | 724,654 | 10,190,000 | 0.57% | ||
| 37 | BNP Paribas Asset Management Holding S.A. | 679,774 | 9,558,000 | 0.53% | ||
| 38 | MACQUARIE GROUP LTD | 650,000 | 9,139,000 | 0.51% | ||
| 39 | VOYA INVESTMENT MANAGEMENT LLC | 614,033 | 8,634,000 | 0.48% | ||
| 40 | AXA S.A. | 599,810 | 8,433,000 | 0.47% | ||
| 41 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 581,750 | 8,179,000 | 0.45% | ||
| 42 | PRUDENTIAL FINANCIAL INC | 561,884 | 7,900,000 | 0.44% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 557,356 | 7,836,000 | 0.43% | ||
| 44 | GOLDMAN SACHS GROUP INC | 514,272 | 7,231,000 | 0.40% | ||
| 45 | PANAGORA ASSET MANAGEMENT INC | 493,397 | 6,937,000 | 0.38% | ||
| 46 | TWO SIGMA INVESTMENTS, LP | 444,523 | 6,250,000 | 0.35% | ||
| 47 | BlackRock Investment Management, LLC | 420,296 | 5,909,000 | 0.33% | ||
| 48 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 419,996 | 5,905,000 | 0.33% | ||
| 49 | EverPoint Asset Management, LLC | 415,000 | 5,835,000 | 0.32% | ||
| 50 | Cupps Capital Management, LLC | 378,787 | 5,325,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
