| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,123,198 | 40,288,000 | 26.35% | ||
| 2 | ACUTA CAPITAL PARTNERS, LLC | 3,964,033 | 12,170,000 | 7.96% | ||
| 3 | ORBIMED ADVISORS LLC | 3,802,000 | 11,672,000 | 7.63% | ||
| 4 | BlackRock Fund Advisors | 3,689,983 | 11,328,000 | 7.41% | ||
| 5 | VANGUARD GROUP INC | 3,441,605 | 10,565,000 | 6.91% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 2,743,613 | 8,423,000 | 5.51% | ||
| 7 | BALYASNY ASSET MANAGEMENT L.P. | 2,259,094 | 6,935,000 | 4.54% | ||
| 8 | BALYASNY ASSET MANAGEMENT L.P. | 1,318,500 | 4,048,000 | 2.65% | Call | |
| 9 | STATE STREET CORP | 1,312,013 | 4,029,000 | 2.64% | ||
| 10 | NORTHERN TRUST CORP | 1,080,082 | 3,315,000 | 2.17% | ||
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,073,640 | 3,296,000 | 2.16% | ||
| 12 | MARSHALL WACE, LLP | 857,062 | 2,631,000 | 1.72% | ||
| 13 | First Light Asset Management, LLC | 850,757 | 2,612,000 | 1.71% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 685,500 | 2,104,000 | 1.38% | Call | |
| 15 | PANAGORA ASSET MANAGEMENT INC | 640,902 | 1,968,000 | 1.29% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 562,750 | 1,727,000 | 1.13% | ||
| 17 | GOLDMAN SACHS GROUP INC | 501,009 | 1,538,000 | 1.01% | ||
| 18 | Bank of New York Mellon Corp | 445,497 | 1,368,000 | 0.89% | ||
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 439,637 | 1,350,000 | 0.88% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 437,000 | 1,342,000 | 0.88% | Put | |
| 21 | Iguana Healthcare Management, LLC | 400,000 | 1,228,000 | 0.80% | ||
| 22 | GROUP ONE TRADING LLC | 343,288 | 1,054,000 | 0.69% | ||
| 23 | BlackRock Investment Management, LLC | 338,296 | 1,039,000 | 0.68% | ||
| 24 | Opaleye Management Inc. | 290,000 | 890,000 | 0.58% | ||
| 25 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 288,900 | 887,000 | 0.58% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 252,109 | 774,000 | 0.51% | ||
| 27 | PERCEPTIVE ADVISORS LLC | 200,000 | 614,000 | 0.40% | ||
| 28 | IFP ADVISORS, INC | 198,517 | 609,000 | 0.40% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 197,048 | 605,000 | 0.40% | ||
| 30 | SVB WEALTH LLC | 195,000 | 599,000 | 0.39% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 178,712 | 549,000 | 0.36% | ||
| 32 | TEACHERS ADVISORS, LLC | 176,467 | 542,000 | 0.35% | ||
| 33 | D. E. Shaw & Co., Inc. | 170,134 | 522,000 | 0.34% | ||
| 34 | BARCLAYS PLC | 163,126 | 489,000 | 0.32% | ||
| 35 | Connor, Clark & Lunn Investment Management Ltd. | 151,400 | 465,000 | 0.30% | ||
| 36 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 149,400 | 459,000 | 0.30% | ||
| 37 | WELLS FARGO & COMPANY/MN | 115,972 | 356,000 | 0.23% | ||
| 38 | Swiss National Bank | 114,250 | 351,000 | 0.23% | ||
| 39 | WOLVERINE ASSET MANAGEMENT LLC | 5,121 | 314,000 | 0.21% | Put | |
| 40 | RHUMBLINE ADVISERS | 100,435 | 308,000 | 0.20% | ||
| 41 | Weiss Multi-Strategy Advisers LLC | 100,000 | 307,000 | 0.20% | ||
| 42 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 93,107 | 286,000 | 0.19% | ||
| 43 | VIRTUS ETF ADVISERS LLC | 92,480 | 284,000 | 0.19% | ||
| 44 | GOLDMAN SACHS GROUP INC | 90,300 | 277,000 | 0.18% | Put | |
| 45 | ProShare Advisors LLC | 90,152 | 277,000 | 0.18% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 87,900 | 270,000 | 0.18% | ||
| 47 | CSS LLC/IL | 86,000 | 264,000 | 0.17% | Put | |
| 48 | CREDIT SUISSE AG/ | 84,465 | 259,000 | 0.17% | ||
| 49 | PointState Capital LP | 80,000 | 246,000 | 0.16% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 74,458 | 229,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
