| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Avoro Capital Advisors LLC | 9,263,340 | 33,996,000 | 14.55% | ||
| 2 | ACUTA CAPITAL PARTNERS, LLC | 4,700,000 | 17,249,000 | 7.38% | ||
| 3 | BlackRock Fund Advisors | 4,604,697 | 16,899,000 | 7.23% | ||
| 4 | VANGUARD GROUP INC | 3,948,219 | 14,490,000 | 6.20% | ||
| 5 | ORBIMED ADVISORS LLC | 3,802,000 | 13,953,000 | 5.97% | ||
| 6 | EverPoint Asset Management, LLC | 3,335,000 | 12,239,000 | 5.24% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 2,863,913 | 10,511,000 | 4.50% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 2,831,007 | 10,390,000 | 4.45% | ||
| 9 | Tourbillon Capital Partners, L.P. | 2,400,000 | 8,808,000 | 3.77% | ||
| 10 | First Light Asset Management, LLC | 2,282,009 | 8,375,000 | 3.58% | ||
| 11 | Ghost Tree Capital, LLC | 1,700,000 | 6,239,000 | 2.67% | ||
| 12 | STATE STREET CORP | 1,610,194 | 5,911,000 | 2.53% | ||
| 13 | ArrowMark Colorado Holdings LLC | 1,524,475 | 5,595,000 | 2.39% | ||
| 14 | Tourbillon Capital Partners, L.P. | 1,500,000 | 5,505,000 | 2.36% | Call | |
| 15 | NORTHERN TRUST CORP | 1,182,109 | 4,338,000 | 1.86% | ||
| 16 | FMR LLC | 1,132,648 | 4,157,000 | 1.78% | ||
| 17 | SPHERA FUNDS MANAGEMENT LTD. | 1,050,000 | 3,854,000 | 1.65% | ||
| 18 | J. Goldman & Co LP | 746,000 | 2,738,000 | 1.17% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 706,085 | 2,591,000 | 1.11% | ||
| 20 | 683 Capital Management, LLC | 575,000 | 2,110,000 | 0.90% | ||
| 21 | DAFNA Capital Management LLC | 559,674 | 2,054,000 | 0.88% | ||
| 22 | Sio Capital Management, LLC | 506,978 | 1,861,000 | 0.80% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 505,422 | 1,855,000 | 0.79% | ||
| 24 | Bank of New York Mellon Corp | 440,697 | 1,617,000 | 0.69% | ||
| 25 | SCHONFELD STRATEGIC ADVISORS LLC | 420,583 | 1,544,000 | 0.66% | ||
| 26 | MORGAN STANLEY | 418,506 | 1,536,000 | 0.66% | ||
| 27 | J. Goldman & Co LP | 390,000 | 1,431,000 | 0.61% | Call | |
| 28 | BlackRock Investment Management, LLC | 360,037 | 1,321,000 | 0.57% | ||
| 29 | PURA VIDA INVESTMENTS, LLC | 336,500 | 1,235,000 | 0.53% | ||
| 30 | PANAGORA ASSET MANAGEMENT INC | 317,691 | 1,166,000 | 0.50% | ||
| 31 | BAILARD, INC. | 315,000 | 1,156,000 | 0.49% | ||
| 32 | WELLS FARGO & COMPANY/MN | 312,096 | 1,146,000 | 0.49% | ||
| 33 | Iguana Healthcare Management, LLC | 300,000 | 1,101,000 | 0.47% | ||
| 34 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 288,900 | 1,060,000 | 0.45% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 278,250 | 1,021,000 | 0.44% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 236,548 | 869,000 | 0.37% | ||
| 37 | CHICAGO EQUITY PARTNERS LLC | 236,055 | 866,000 | 0.37% | ||
| 38 | WOLVERINE ASSET MANAGEMENT LLC | 215,500 | 790,000 | 0.34% | Put | |
| 39 | CITIGROUP INC | 212,200 | 779,000 | 0.33% | Call | |
| 40 | CSS LLC/IL | 207,800 | 763,000 | 0.33% | Put | |
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 200,489 | 736,000 | 0.31% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 185,498 | 681,000 | 0.29% | ||
| 43 | TEACHERS ADVISORS, LLC | 185,661 | 681,000 | 0.29% | ||
| 44 | BARCLAYS PLC | 164,300 | 603,000 | 0.26% | Call | |
| 45 | Swiss National Bank | 163,450 | 600,000 | 0.26% | ||
| 46 | IFP ADVISORS, INC | 163,017 | 598,000 | 0.26% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 153,100 | 562,000 | 0.24% | Call | |
| 48 | GOLDMAN SACHS GROUP INC | 150,126 | 551,000 | 0.24% | ||
| 49 | SVB WEALTH LLC | 145,000 | 532,000 | 0.23% | ||
| 50 | CITADEL ADVISORS LLC | 134,700 | 494,000 | 0.21% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
