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Institutional Investment Manager
Opaleye Management Inc.
Opaleye Management Inc. (CIK: 0001595855) incorporated in Massachusetts, located at One Boston Place, Boston, MA. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q4)
Portfolio Summary: 53 holdings with a total value of $239,178,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 ULTRAGENYX PHARMACEUTICAL INC COM 110,000 12,340,000 5.16%
2 AXOGEN INC 2,120,000 10,600,000 4.43%
3 FIBROGEN INC COM 325,000 9,903,000 4.14%
4 GERON CORP 1,825,000 8,833,000 3.69%
5 MEDGENICS INC 1,390,000 8,368,000 3.50%
6 IMPRIMIS PHARMACEUTICALS INC 1,205,000 8,351,000 3.49%
7 PROTALIX BIOTHERAPEUTICS INC 8,100,000 8,262,000 3.45%
8 OPHTHOTECH CORP COM 105,000 8,246,000 3.45%
9 ARIAD PHARMACEUTICALS INC 1,310,000 8,188,000 3.42%
10 EAGLE PHARMACEUTICALS INC COM 85,000 7,537,000 3.15%
11 INOTEK PHARMACEUTICALS CORP 645,000 7,308,000 3.06%
12 BLUEPRINT MEDICINES CORP COM 275,000 7,244,000 3.03%
13 CARA THERAPEUTICS INC 427,000 7,199,000 3.01%
14 CODEXIS INC 1,600,000 6,768,000 2.83%
15 RETROPHIN INC COM 345,000 6,655,000 2.78%
16 RELYPSA INC 220,000 6,235,000 2.61%
17 CEMPRA INC 200,000 6,226,000 2.60%
18 SAGE THERAPEUTICS 100,000 5,830,000 2.44%
19 SUPERNUS PHARMACEUTICALS INC COM 420,000 5,645,000 2.36%
20 DEPOMED INC 300,000 5,439,000 2.27%
21 ADAMAS PHARMACEUTICALS INC 190,000 5,380,000 2.25%
22 AMAG PHARMACEUTICALS INC COM 150,000 4,529,000 1.89%
23 TONIX PHARMACEUTICALS HLD 565,000 4,334,000 1.81%
24 AVINGER INC 190,000 4,315,000 1.80%
25 AFFIMED N V 595,000 4,236,000 1.77%
26 Foamix Pharmaceuticals Ltd. 500,000 4,055,000 1.70%
27 EAGLE PHARMACEUTICALS INC 1,440,000 3,816,000 1.60%
28 LA JOLLA PHARMACEUTICAL CO 140,000 3,780,000 1.58%
29 TG THERAPEUTICS INC COM 300,000 3,579,000 1.50%
30 Intec Pharma Ltd 630,000 3,377,000 1.41%
31 AMARIN CORP PLC 1,760,000 3,326,000 1.39%
32 NEUROCRINE BIOSCIE COM USD0.001 55,000 3,111,000 1.30%
33 FLAMEL TECHNOLOGIES SA SPONSORED ADR 250,000 3,053,000 1.28%
34 Agile Therapeutics, Inc. 300,000 2,928,000 1.22%
35 CORIUM INTERNATIONAL INC 355,000 2,883,000 1.21%
36 TRILLIUM THERAPEUTICS INC 210,000 2,648,000 1.11%
37 XENON PHARMACEUTICALS INC 300,000 2,412,000 1.01%
38 XOMA CORP DEL 1,700,000 2,261,000 0.95%
39 ZOGENIX INC 150,000 2,211,000 0.92%
40 ALDER BIOPHARMACEUTICALS INC 65,000 2,147,000 0.90%
41 Nabriva Therapeutics AG 220,000 2,116,000 0.88%
42 AURIS MED HLDG AG 375,000 1,834,000 0.77%
43 TENAX THERAPEUTICS INC COM 540,000 1,771,000 0.74%
44 CYNAPSUS THERAPEUTICS INC 110,000 1,682,000 0.70%
45 ACCELERATE DIAGNOSTICS INC 75,000 1,612,000 0.67%
46 CELLECTIS S A 50,000 1,552,000 0.65%
47 MACROGENICS INC 35,000 1,084,000 0.45%
48 VITAE PHARMACEUTICALS INC 58,500 1,059,000 0.44%
49 IMMUNOMEDICS INC 290,000 890,000 0.37%
50 ACHAOGEN INC 125,000 718,000 0.30%
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Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001546927-16-000408, filed 2016.02.12).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.