| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Avoro Capital Advisors LLC | 7,344,177 | 23,869,000 | 13.59% | ||
| 2 | ACUTA CAPITAL PARTNERS, LLC | 3,850,000 | 12,513,000 | 7.13% | ||
| 3 | ORBIMED ADVISORS LLC | 3,802,000 | 12,357,000 | 7.04% | ||
| 4 | VANGUARD GROUP INC | 3,752,828 | 12,197,000 | 6.95% | ||
| 5 | BlackRock Fund Advisors | 3,743,062 | 12,165,000 | 6.93% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 2,792,320 | 9,075,000 | 5.17% | ||
| 7 | Tourbillon Capital Partners, L.P. | 2,400,000 | 7,800,000 | 4.44% | ||
| 8 | Ghost Tree Capital, LLC | 2,000,000 | 6,500,000 | 3.70% | ||
| 9 | J. Goldman & Co LP | 1,696,699 | 5,514,000 | 3.14% | ||
| 10 | BALYASNY ASSET MANAGEMENT L.P. | 1,569,885 | 5,102,000 | 2.91% | ||
| 11 | Tourbillon Capital Partners, L.P. | 1,500,000 | 4,876,000 | 2.78% | Call | |
| 12 | STATE STREET CORP | 1,431,793 | 4,651,000 | 2.65% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 1,277,794 | 4,153,000 | 2.36% | ||
| 14 | NEXTHERA CAPITAL LP | 1,263,276 | 4,106,000 | 2.34% | ||
| 15 | Opaleye Management Inc. | 1,200,000 | 3,900,000 | 2.22% | ||
| 16 | FMR LLC | 1,132,648 | 3,681,000 | 2.10% | ||
| 17 | NORTHERN TRUST CORP | 1,048,928 | 3,409,000 | 1.94% | ||
| 18 | First Light Asset Management, LLC | 992,867 | 3,227,000 | 1.84% | ||
| 19 | PANAGORA ASSET MANAGEMENT INC | 909,852 | 2,957,000 | 1.68% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 623,138 | 2,025,000 | 1.15% | ||
| 21 | DAFNA Capital Management LLC | 566,796 | 1,842,000 | 1.05% | ||
| 22 | Bank of New York Mellon Corp | 408,664 | 1,328,000 | 0.76% | ||
| 23 | SPHERA FUNDS MANAGEMENT LTD. | 400,000 | 1,300,000 | 0.74% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 384,674 | 1,250,000 | 0.71% | ||
| 25 | NORGES BANK | 400,000 | 1,242,000 | 0.71% | ||
| 26 | GROUP ONE TRADING LLC | 366,307 | 1,191,000 | 0.68% | ||
| 27 | BlackRock Investment Management, LLC | 353,111 | 1,148,000 | 0.65% | ||
| 28 | PURA VIDA INVESTMENTS, LLC | 319,565 | 1,039,000 | 0.59% | ||
| 29 | BAILARD, INC. | 315,000 | 1,024,000 | 0.58% | ||
| 30 | Iguana Healthcare Management, LLC | 300,000 | 975,000 | 0.56% | ||
| 31 | SABBY MANAGEMENT, LLC | 297,310 | 966,000 | 0.55% | ||
| 32 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 288,900 | 939,000 | 0.53% | ||
| 33 | WELLS FARGO & COMPANY/MN | 221,227 | 719,000 | 0.41% | ||
| 34 | WOLVERINE ASSET MANAGEMENT LLC | 217,200 | 705,000 | 0.40% | Put | |
| 35 | CSS LLC/IL | 207,900 | 675,000 | 0.38% | Put | |
| 36 | CHICAGO EQUITY PARTNERS LLC | 205,345 | 667,000 | 0.38% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 199,441 | 648,000 | 0.37% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 197,048 | 641,000 | 0.36% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 185,498 | 603,000 | 0.34% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 184,289 | 599,000 | 0.34% | ||
| 41 | TEACHERS ADVISORS, LLC | 170,514 | 554,000 | 0.32% | ||
| 42 | IFP ADVISORS, INC | 163,017 | 530,000 | 0.30% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 149,100 | 485,000 | 0.28% | Call | |
| 44 | Swiss National Bank | 145,450 | 473,000 | 0.27% | ||
| 45 | SVB WEALTH LLC | 145,000 | 471,000 | 0.27% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 133,200 | 433,000 | 0.25% | Put | |
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 127,600 | 415,000 | 0.24% | ||
| 48 | BLACKROCK ADVISORS LLC | 119,057 | 386,000 | 0.22% | ||
| 49 | CITADEL ADVISORS LLC | 115,100 | 374,000 | 0.21% | Call | |
| 50 | PRICE T ROWE ASSOCIATES INC /MD/ | 113,100 | 368,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
