| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Avoro Capital Advisors LLC | 8,556,957 | 19,852,000 | 15.57% | ||
| 2 | ACUTA CAPITAL PARTNERS, LLC | 4,200,000 | 9,744,000 | 7.64% | ||
| 3 | ORBIMED ADVISORS LLC | 3,802,000 | 8,821,000 | 6.92% | ||
| 4 | VANGUARD GROUP INC | 3,677,769 | 8,533,000 | 6.69% | ||
| 5 | BlackRock Fund Advisors | 3,501,476 | 8,123,000 | 6.37% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 2,682,248 | 6,223,000 | 4.88% | ||
| 7 | Tourbillon Capital Partners, L.P. | 2,400,000 | 5,568,000 | 4.37% | ||
| 8 | STATE STREET CORP | 2,354,732 | 5,463,000 | 4.28% | ||
| 9 | RENAISSANCE TECHNOLOGIES LLC | 1,772,807 | 4,113,000 | 3.23% | ||
| 10 | Tourbillon Capital Partners, L.P. | 1,500,000 | 3,480,000 | 2.73% | Call | |
| 11 | Opaleye Management Inc. | 1,300,000 | 3,016,000 | 2.36% | ||
| 12 | FMR LLC | 1,132,648 | 2,628,000 | 2.06% | ||
| 13 | BALYASNY ASSET MANAGEMENT L.P. | 1,095,676 | 2,542,000 | 1.99% | ||
| 14 | NORTHERN TRUST CORP | 1,038,770 | 2,410,000 | 1.89% | ||
| 15 | Ghost Tree Capital, LLC | 1,000,000 | 2,320,000 | 1.82% | ||
| 16 | First Light Asset Management, LLC | 987,854 | 2,292,000 | 1.80% | ||
| 17 | PANAGORA ASSET MANAGEMENT INC | 980,444 | 2,275,000 | 1.78% | ||
| 18 | DEUTSCHE BANK AG\ | 959,171 | 2,223,000 | 1.74% | ||
| 19 | DAFNA Capital Management LLC | 815,000 | 1,891,000 | 1.48% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 614,033 | 1,424,000 | 1.12% | ||
| 21 | GROUP ONE TRADING LLC | 462,247 | 1,072,000 | 0.84% | ||
| 22 | Bank of New York Mellon Corp | 431,506 | 1,001,000 | 0.78% | ||
| 23 | SABBY MANAGEMENT, LLC | 425,000 | 986,000 | 0.77% | ||
| 24 | NORGES BANK | 400,000 | 928,000 | 0.73% | ||
| 25 | SPHERA FUNDS MANAGEMENT LTD. | 400,000 | 928,000 | 0.73% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 386,678 | 897,000 | 0.70% | ||
| 27 | BlackRock Investment Management, LLC | 349,301 | 810,000 | 0.64% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 328,329 | 762,000 | 0.60% | ||
| 29 | BAILARD, INC. | 315,000 | 731,000 | 0.57% | ||
| 30 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 288,900 | 670,000 | 0.53% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 288,000 | 668,000 | 0.52% | Put | |
| 32 | MILLENNIUM MANAGEMENT LLC | 259,762 | 603,000 | 0.47% | ||
| 33 | CSS LLC/IL | 258,400 | 598,000 | 0.47% | Put | |
| 34 | WELLS FARGO & COMPANY/MN | 227,673 | 529,000 | 0.41% | ||
| 35 | Iguana Healthcare Management, LLC | 225,000 | 522,000 | 0.41% | ||
| 36 | PERCEPTIVE ADVISORS LLC | 221,700 | 514,000 | 0.40% | ||
| 37 | Quantitative Systematic Strategies LLC | 217,000 | 497,000 | 0.39% | ||
| 38 | Ghost Tree Capital, LLC | 200,000 | 464,000 | 0.36% | Call | |
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 197,048 | 458,000 | 0.36% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 185,498 | 430,000 | 0.34% | ||
| 41 | Candriam S.C.A. | 185,000 | 429,000 | 0.34% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 182,989 | 425,000 | 0.33% | ||
| 43 | WOLVERINE ASSET MANAGEMENT LLC | 171,800 | 398,000 | 0.31% | Put | |
| 44 | TEACHERS ADVISORS, LLC | 170,514 | 396,000 | 0.31% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 163,900 | 380,000 | 0.30% | Call | |
| 46 | IFP ADVISORS, INC | 163,017 | 378,000 | 0.30% | ||
| 47 | GOLDMAN SACHS GROUP INC | 149,778 | 347,000 | 0.27% | ||
| 48 | Swiss National Bank | 145,450 | 337,000 | 0.26% | ||
| 49 | SVB WEALTH LLC | 145,000 | 336,000 | 0.26% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 136,500 | 317,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
