| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 1,830,899 | 77,191,000 | 12.99% | ||
| 2 | Consonance Capital Management LP | 1,254,247 | 52,879,000 | 8.90% | ||
| 3 | ORBIMED ADVISORS LLC | 1,243,200 | 52,413,000 | 8.82% | ||
| 4 | FMR LLC | 1,039,770 | 43,837,000 | 7.38% | ||
| 5 | BlackRock Fund Advisors | 695,087 | 29,305,000 | 4.93% | ||
| 6 | VANGUARD GROUP INC | 627,047 | 26,436,000 | 4.45% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 621,350 | 26,196,000 | 4.41% | ||
| 8 | Point72 Asset Management, L.P. | 603,750 | 25,454,000 | 4.28% | ||
| 9 | EverPoint Asset Management, LLC | 520,000 | 21,923,000 | 3.69% | ||
| 10 | Invesco Ltd. | 351,359 | 14,813,000 | 2.49% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 326,220 | 13,753,000 | 2.31% | ||
| 12 | Empyrean Capital Partners, LP | 309,821 | 13,062,000 | 2.20% | ||
| 13 | DIMENSIONAL FUND ADVISORS LP | 294,038 | 12,397,000 | 2.09% | ||
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 281,562 | 11,871,000 | 2.00% | ||
| 15 | MORGAN STANLEY | 276,574 | 11,660,000 | 1.96% | ||
| 16 | Asset Management One Co., Ltd. | 272,060 | 11,475,000 | 1.93% | ||
| 17 | FRONTIER CAPITAL MANAGEMENT CO LLC | 235,457 | 9,927,000 | 1.67% | ||
| 18 | Allianz Asset Management GmbH | 204,844 | 8,636,000 | 1.45% | ||
| 19 | JW Asset Management, LLC | 191,027 | 8,054,000 | 1.36% | ||
| 20 | WELLS FARGO & COMPANY/MN | 174,953 | 7,377,000 | 1.24% | ||
| 21 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 164,810 | 6,948,000 | 1.17% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 145,000 | 6,113,000 | 1.03% | Call | |
| 23 | STATE STREET CORP | 127,332 | 5,365,000 | 0.90% | ||
| 24 | WADDELL & REED FINANCIAL INC | 126,600 | 5,337,000 | 0.90% | ||
| 25 | Opaleye Management Inc. | 122,500 | 5,165,000 | 0.87% | ||
| 26 | NORTHERN TRUST CORP | 109,374 | 4,611,000 | 0.78% | ||
| 27 | Ghost Tree Capital, LLC | 100,000 | 4,216,000 | 0.71% | ||
| 28 | QS Investors, LLC | 94,118 | 3,969,000 | 0.67% | ||
| 29 | GUGGENHEIM CAPITAL LLC | 91,498 | 3,858,000 | 0.65% | ||
| 30 | J. Goldman & Co LP | 82,500 | 3,478,000 | 0.59% | ||
| 31 | PUTNAM INVESTMENTS LLC | 73,668 | 3,106,000 | 0.52% | ||
| 32 | A.R.T. Advisors, LLC | 69,357 | 2,924,000 | 0.49% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 64,988 | 2,739,000 | 0.46% | ||
| 34 | GOLDMAN SACHS GROUP INC | 63,791 | 2,690,000 | 0.45% | ||
| 35 | Bank of New York Mellon Corp | 63,309 | 2,669,000 | 0.45% | ||
| 36 | DEUTSCHE BANK AG\ | 59,335 | 2,501,000 | 0.42% | ||
| 37 | CREDIT SUISSE AG/ | 52,910 | 2,230,000 | 0.38% | ||
| 38 | ANALYTIC INVESTORS, LLC | 50,114 | 2,113,000 | 0.36% | ||
| 39 | GOLDMAN SACHS GROUP INC | 50,000 | 2,108,000 | 0.35% | Put | |
| 40 | SHELL ASSET MANAGEMENT CO | 49,706 | 2,096,000 | 0.35% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,600 | 1,965,000 | 0.33% | Put | |
| 42 | Weiss Multi-Strategy Advisers LLC | 44,000 | 1,855,000 | 0.31% | ||
| 43 | GAM Holding AG | 41,970 | 1,769,000 | 0.30% | ||
| 44 | DEERE & CO | 41,701 | 1,758,000 | 0.30% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 35,932 | 1,515,000 | 0.25% | ||
| 46 | COLUMBUS CIRCLE INVESTORS | 34,616 | 1,459,000 | 0.25% | ||
| 47 | AQR CAPITAL MANAGEMENT LLC | 31,352 | 1,322,000 | 0.22% | ||
| 48 | DUPONT CAPITAL MANAGEMENT CORP | 28,869 | 1,217,000 | 0.20% | ||
| 49 | BlackRock Investment Management, LLC | 28,808 | 1,215,000 | 0.20% | ||
| 50 | BANK OF MONTREAL /CAN/ | 28,553 | 1,203,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
