| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 4,081,800 | 116,168,000 | 10.51% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 3,687,383 | 104,943,000 | 9.50% | ||
| 3 | Consonance Capital Management LP | 3,257,094 | 92,697,000 | 8.39% | ||
| 4 | FMR LLC | 2,466,984 | 70,210,000 | 6.35% | ||
| 5 | VANGUARD GROUP INC | 1,861,041 | 52,965,000 | 4.79% | ||
| 6 | SCOPIA CAPITAL MANAGEMENT LP | 1,718,487 | 48,908,000 | 4.43% | ||
| 7 | BlackRock Fund Advisors | 1,585,310 | 45,118,000 | 4.08% | ||
| 8 | Invesco Ltd. | 1,281,371 | 36,468,000 | 3.30% | ||
| 9 | GOLDMAN SACHS GROUP INC | 1,149,500 | 32,715,000 | 2.96% | Put | |
| 10 | STATE STREET CORP | 1,046,083 | 29,775,000 | 2.70% | ||
| 11 | CITADEL ADVISORS LLC | 966,417 | 27,505,000 | 2.49% | ||
| 12 | WELLS FARGO & COMPANY/MN | 839,525 | 23,893,000 | 2.16% | ||
| 13 | GOLDMAN SACHS GROUP INC | 800,000 | 22,768,000 | 2.06% | Call | |
| 14 | NEXT CENTURY GROWTH INVESTORS LLC | 788,534 | 22,441,000 | 2.03% | ||
| 15 | DIMENSIONAL FUND ADVISORS LP | 732,349 | 20,842,000 | 1.89% | ||
| 16 | GOLDMAN SACHS GROUP INC | 714,846 | 20,345,000 | 1.84% | ||
| 17 | GLENMEDE TRUST CO NA | 622,293 | 17,710,000 | 1.60% | ||
| 18 | BARCLAYS PLC | 593,800 | 16,626,000 | 1.50% | Put | |
| 19 | BlackRock Institutional Trust Company, N.A. | 554,619 | 15,784,000 | 1.43% | ||
| 20 | STRS OHIO | 501,600 | 14,275,000 | 1.29% | ||
| 21 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 402,968 | 11,468,000 | 1.04% | ||
| 22 | Anson Funds Management LP | 400,200 | 11,390,000 | 1.03% | Put | |
| 23 | LOOMIS SAYLES & CO L P | 398,827 | 11,351,000 | 1.03% | ||
| 24 | JW Asset Management, LLC | 388,346 | 11,052,000 | 1.00% | ||
| 25 | TEACHERS ADVISORS, LLC | 339,502 | 9,662,000 | 0.87% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 332,968 | 9,476,000 | 0.86% | ||
| 27 | Asset Management One Co., Ltd. | 337,595 | 9,223,000 | 0.83% | ||
| 28 | Rock Springs Capital Management LP | 308,000 | 8,766,000 | 0.79% | ||
| 29 | JPMORGAN CHASE & CO | 303,917 | 8,650,000 | 0.78% | ||
| 30 | VALINOR MANAGEMENT, L.P. | 292,436 | 8,323,000 | 0.75% | ||
| 31 | NORTHERN TRUST CORP | 269,887 | 7,681,000 | 0.70% | ||
| 32 | FRONTIER CAPITAL MANAGEMENT CO LLC | 269,221 | 7,662,000 | 0.69% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 254,100 | 7,232,000 | 0.65% | Put | |
| 34 | MACQUARIE GROUP LTD | 220,751 | 6,283,000 | 0.57% | ||
| 35 | GUGGENHEIM CAPITAL LLC | 213,824 | 6,085,000 | 0.55% | ||
| 36 | WADDELL & REED FINANCIAL INC | 213,300 | 6,071,000 | 0.55% | ||
| 37 | BELLEVUE ASSET MANAGEMENT AG | 210,000 | 5,977,000 | 0.54% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 205,300 | 5,843,000 | 0.53% | Call | |
| 39 | QS Investors, LLC | 186,036 | 5,295,000 | 0.48% | ||
| 40 | MORGAN STANLEY | 183,781 | 5,232,000 | 0.47% | ||
| 41 | BARCLAYS PLC | 185,353 | 5,189,000 | 0.47% | ||
| 42 | RUSSELL FRANK CO/ | 174,892 | 4,977,000 | 0.45% | ||
| 43 | GEODE CAPITAL MANAGEMENT, LLC | 173,451 | 4,936,000 | 0.45% | ||
| 44 | AMERIPRISE FINANCIAL INC | 168,747 | 4,802,000 | 0.43% | ||
| 45 | PRICE T ROWE ASSOCIATES INC /MD/ | 154,400 | 4,394,000 | 0.40% | ||
| 46 | Bank of New York Mellon Corp | 129,218 | 3,677,000 | 0.33% | ||
| 47 | NORGES BANK | 123,998 | 3,529,000 | 0.32% | ||
| 48 | DEUTSCHE BANK AG\ | 119,914 | 3,410,000 | 0.31% | ||
| 49 | PUTNAM INVESTMENTS LLC | 94,227 | 2,681,000 | 0.24% | ||
| 50 | WELLINGTON MANAGEMENT GROUP LLP | 90,074 | 2,564,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
