| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 1,609,402 | 93,555,000 | 11.04% | ||
| 2 | Consonance Capital Management LP | 1,359,247 | 79,013,000 | 9.32% | ||
| 3 | ORBIMED ADVISORS LLC | 1,243,200 | 72,267,000 | 8.53% | ||
| 4 | FMR LLC | 1,228,492 | 71,412,000 | 8.42% | ||
| 5 | VANGUARD GROUP INC | 861,615 | 50,086,000 | 5.91% | ||
| 6 | BlackRock Fund Advisors | 717,195 | 41,691,000 | 4.92% | ||
| 7 | STATE STREET CORP | 511,634 | 29,742,000 | 3.51% | ||
| 8 | FRONTIER CAPITAL MANAGEMENT CO LLC | 354,795 | 20,624,000 | 2.43% | ||
| 9 | TEACHERS ADVISORS, LLC | 343,787 | 19,984,000 | 2.36% | ||
| 10 | LOOMIS SAYLES & CO L P | 328,107 | 19,073,000 | 2.25% | ||
| 11 | DIMENSIONAL FUND ADVISORS LP | 326,738 | 18,993,000 | 2.24% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 322,329 | 18,737,000 | 2.21% | ||
| 13 | Invesco Ltd. | 301,972 | 17,554,000 | 2.07% | ||
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 275,000 | 15,986,000 | 1.89% | ||
| 15 | NEXT CENTURY GROWTH INVESTORS LLC | 273,594 | 15,904,000 | 1.88% | ||
| 16 | TIAA CREF INVESTMENT MANAGEMENT LLC | 230,705 | 13,411,000 | 1.58% | ||
| 17 | Asset Management One Co., Ltd. | 215,732 | 12,307,000 | 1.45% | ||
| 18 | STRS OHIO | 208,300 | 12,108,000 | 1.43% | ||
| 19 | Allianz Asset Management GmbH | 196,969 | 11,449,000 | 1.35% | ||
| 20 | JW Asset Management, LLC | 187,118 | 10,877,000 | 1.28% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 182,937 | 10,634,000 | 1.25% | ||
| 22 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 168,033 | 9,768,000 | 1.15% | ||
| 23 | WELLS FARGO & COMPANY/MN | 160,067 | 9,303,000 | 1.10% | ||
| 24 | WADDELL & REED FINANCIAL INC | 142,600 | 8,289,000 | 0.98% | ||
| 25 | NORTHERN TRUST CORP | 110,086 | 6,399,000 | 0.75% | ||
| 26 | Opaleye Management Inc. | 110,000 | 6,394,000 | 0.75% | ||
| 27 | GUGGENHEIM CAPITAL LLC | 106,010 | 6,162,000 | 0.73% | ||
| 28 | SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 5,813,000 | 0.69% | ||
| 29 | EverPoint Asset Management, LLC | 100,000 | 5,813,000 | 0.69% | ||
| 30 | Timpani Capital Management LLC | 97,919 | 5,692,000 | 0.67% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 96,800 | 5,627,000 | 0.66% | Call | |
| 32 | QS Investors, LLC | 94,118 | 5,470,000 | 0.65% | ||
| 33 | MORGAN STANLEY | 80,524 | 4,681,000 | 0.55% | ||
| 34 | CITADEL ADVISORS LLC | 72,958 | 4,241,000 | 0.50% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 69,475 | 4,038,000 | 0.48% | ||
| 36 | RUSSELL FRANK CO/ | 66,524 | 3,867,000 | 0.46% | ||
| 37 | DEUTSCHE BANK AG\ | 64,990 | 3,776,000 | 0.45% | ||
| 38 | Bank of New York Mellon Corp | 64,753 | 3,764,000 | 0.44% | ||
| 39 | JPMORGAN CHASE & CO | 62,779 | 3,649,000 | 0.43% | ||
| 40 | DUPONT CAPITAL MANAGEMENT CORP | 61,479 | 3,574,000 | 0.42% | ||
| 41 | FEDERATED HERMES, INC. | 59,000 | 3,430,000 | 0.40% | ||
| 42 | AHL Partners LLP | 56,345 | 3,275,000 | 0.39% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,000 | 3,255,000 | 0.38% | Put | |
| 44 | PUTNAM INVESTMENTS LLC | 51,460 | 2,992,000 | 0.35% | ||
| 45 | SHELL ASSET MANAGEMENT CO | 49,560 | 2,881,000 | 0.34% | ||
| 46 | PRICE T ROWE ASSOCIATES INC /MD/ | 47,100 | 2,738,000 | 0.32% | ||
| 47 | ANALYTIC INVESTORS, LLC | 46,239 | 2,688,000 | 0.32% | ||
| 48 | Weiss Multi-Strategy Advisers LLC | 45,000 | 2,616,000 | 0.31% | ||
| 49 | AMERIPRISE FINANCIAL INC | 42,724 | 2,483,000 | 0.29% | ||
| 50 | GAM Holding AG | 41,970 | 2,440,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
