| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SCOPIA CAPITAL MANAGEMENT LP | 5,824,085 | 166,744,000 | 14.17% | ||
| 2 | ORBIMED ADVISORS LLC | 4,366,740 | 125,020,000 | 10.63% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 2,956,062 | 84,632,000 | 7.19% | ||
| 4 | Consonance Capital Management LP | 2,568,684 | 73,541,000 | 6.25% | ||
| 5 | FMR LLC | 2,466,984 | 70,630,000 | 6.00% | ||
| 6 | VANGUARD GROUP INC | 2,275,622 | 65,151,000 | 5.54% | ||
| 7 | BlackRock Fund Advisors | 1,415,828 | 40,535,000 | 3.45% | ||
| 8 | STATE STREET CORP | 1,201,824 | 34,409,000 | 2.92% | ||
| 9 | FOLGER HILL ASSET MANAGEMENT LP | 999,347 | 28,611,000 | 2.43% | ||
| 10 | Gotham Asset Management, LLC | 830,540 | 23,778,000 | 2.02% | ||
| 11 | NEXT CENTURY GROWTH INVESTORS LLC | 777,668 | 22,264,000 | 1.89% | ||
| 12 | VALINOR MANAGEMENT, L.P. | 586,926 | 16,804,000 | 1.43% | ||
| 13 | DIMENSIONAL FUND ADVISORS LP | 583,172 | 16,697,000 | 1.42% | ||
| 14 | Antipodean Advisors LLC | 570,285 | 16,327,000 | 1.39% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 563,541 | 16,134,000 | 1.37% | ||
| 16 | CITADEL ADVISORS LLC | 446,129 | 12,773,000 | 1.09% | ||
| 17 | STRS OHIO | 430,000 | 12,310,000 | 1.05% | ||
| 18 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 425,227 | 12,174,000 | 1.03% | ||
| 19 | FRONTIER CAPITAL MANAGEMENT CO LLC | 380,434 | 10,892,000 | 0.93% | ||
| 20 | Invesco Ltd. | 366,963 | 10,506,000 | 0.89% | ||
| 21 | GOLDMAN SACHS GROUP INC | 365,034 | 10,451,000 | 0.89% | ||
| 22 | JW Asset Management, LLC | 350,978 | 10,049,000 | 0.85% | ||
| 23 | Rock Springs Capital Management LP | 338,500 | 9,691,000 | 0.82% | ||
| 24 | TEACHERS ADVISORS, LLC | 333,927 | 9,560,000 | 0.81% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 327,060 | 9,364,000 | 0.80% | ||
| 26 | MACQUARIE GROUP LTD | 318,001 | 9,104,000 | 0.77% | ||
| 27 | BLACKROCK ADVISORS LLC | 297,850 | 8,527,000 | 0.72% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 296,400 | 8,486,000 | 0.72% | Put | |
| 29 | Asset Management One Co., Ltd. | 282,919 | 8,190,000 | 0.70% | ||
| 30 | RUSSELL FRANK CO/ | 275,455 | 8,093,000 | 0.69% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 278,900 | 7,985,000 | 0.68% | Call | |
| 32 | OXFORD ASSET MANAGEMENT LLP | 276,651 | 7,973,000 | 0.68% | ||
| 33 | NORTHERN TRUST CORP | 278,037 | 7,961,000 | 0.68% | ||
| 34 | Valiant Capital Management, L.P. | 277,500 | 7,945,000 | 0.68% | ||
| 35 | TWO SIGMA INVESTMENTS, LP | 271,754 | 7,780,000 | 0.66% | ||
| 36 | FIRST MANHATTAN CO. LLC. | 270,100 | 7,732,000 | 0.66% | ||
| 37 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 265,000 | 7,587,000 | 0.64% | ||
| 38 | HIGHLAND CAPITAL MANAGEMENT LP | 251,165 | 7,190,000 | 0.61% | ||
| 39 | BELLEVUE ASSET MANAGEMENT AG | 232,000 | 6,642,000 | 0.56% | ||
| 40 | JPMORGAN CHASE & CO | 227,819 | 6,522,000 | 0.55% | ||
| 41 | GSA CAPITAL PARTNERS LLP | 226,712 | 6,491,000 | 0.55% | ||
| 42 | NORGES BANK | 214,534 | 6,142,000 | 0.52% | ||
| 43 | SKANDINAVISKA ENSKILDA BANKEN AB (PUBL) | 197,500 | 5,803,000 | 0.49% | ||
| 44 | QS Investors, LLC | 182,135 | 5,215,000 | 0.44% | ||
| 45 | GUGGENHEIM CAPITAL LLC | 180,544 | 5,169,000 | 0.44% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 172,670 | 4,944,000 | 0.42% | ||
| 47 | GEODE CAPITAL MANAGEMENT, LLC | 166,604 | 4,769,000 | 0.41% | ||
| 48 | DEUTSCHE BANK AG\ | 161,556 | 4,624,000 | 0.39% | ||
| 49 | AMERIPRISE FINANCIAL INC | 154,763 | 4,431,000 | 0.38% | ||
| 50 | PRICE T ROWE ASSOCIATES INC /MD/ | 149,060 | 4,268,000 | 0.36% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
