| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 3,423,705 | 122,979,000 | 10.22% | ||
| 2 | Consonance Capital Management LP | 2,984,094 | 107,189,000 | 8.91% | ||
| 3 | ORBIMED ADVISORS LLC | 2,623,000 | 94,218,000 | 7.83% | ||
| 4 | FMR LLC | 2,456,984 | 88,255,000 | 7.33% | ||
| 5 | VANGUARD GROUP INC | 1,799,892 | 64,652,000 | 5.37% | ||
| 6 | BlackRock Fund Advisors | 1,485,339 | 53,353,000 | 4.43% | ||
| 7 | STATE STREET CORP | 1,079,615 | 38,787,000 | 3.22% | ||
| 8 | Invesco Ltd. | 962,903 | 34,587,000 | 2.87% | ||
| 9 | SCOPIA CAPITAL MANAGEMENT LP | 871,914 | 31,319,000 | 2.60% | ||
| 10 | LOOMIS SAYLES & CO L P | 738,473 | 26,526,000 | 2.20% | ||
| 11 | BLOOM TREE PARTNERS, LLC | 704,006 | 25,288,000 | 2.10% | ||
| 12 | DIMENSIONAL FUND ADVISORS LP | 654,280 | 23,501,000 | 1.95% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 640,600 | 23,010,000 | 1.91% | ||
| 14 | BARCLAYS PLC | 593,800 | 20,783,000 | 1.73% | Put | |
| 15 | NEXT CENTURY GROWTH INVESTORS LLC | 529,743 | 19,028,000 | 1.58% | ||
| 16 | GOLDMAN SACHS GROUP INC | 510,000 | 18,319,000 | 1.52% | Call | |
| 17 | GLENMEDE TRUST CO NA | 503,473 | 18,083,000 | 1.50% | ||
| 18 | TEACHERS ADVISORS, LLC | 497,437 | 17,868,000 | 1.48% | ||
| 19 | Freshford Capital Management, LLC | 452,600 | 16,258,000 | 1.35% | Put | |
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 413,500 | 14,853,000 | 1.23% | Put | |
| 21 | JW Asset Management, LLC | 384,644 | 13,816,000 | 1.15% | ||
| 22 | Asset Management One Co., Ltd. | 387,455 | 13,451,000 | 1.12% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 358,950 | 12,893,000 | 1.07% | ||
| 24 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 344,396 | 12,371,000 | 1.03% | ||
| 25 | STRS OHIO | 336,700 | 12,094,000 | 1.00% | ||
| 26 | WADDELL & REED FINANCIAL INC | 307,132 | 11,032,000 | 0.92% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 294,100 | 10,564,000 | 0.88% | Call | |
| 28 | FRONTIER CAPITAL MANAGEMENT CO LLC | 282,589 | 10,151,000 | 0.84% | ||
| 29 | PDT Partners, LLC | 243,628 | 8,751,000 | 0.73% | ||
| 30 | JPMORGAN CHASE & CO | 235,146 | 8,447,000 | 0.70% | ||
| 31 | NORTHERN TRUST CORP | 232,940 | 8,367,000 | 0.70% | ||
| 32 | Allianz Asset Management GmbH | 206,016 | 7,400,000 | 0.61% | ||
| 33 | GUGGENHEIM CAPITAL LLC | 202,087 | 7,259,000 | 0.60% | ||
| 34 | PEAK6 Group LLC | 201,700 | 7,245,000 | 0.60% | Call | |
| 35 | CITADEL ADVISORS LLC | 198,913 | 7,144,000 | 0.59% | ||
| 36 | TWO SIGMA INVESTMENTS, LP | 191,095 | 6,864,000 | 0.57% | ||
| 37 | QS Investors, LLC | 188,236 | 6,761,000 | 0.56% | ||
| 38 | PEAK6 Group LLC | 177,700 | 6,383,000 | 0.53% | Put | |
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 148,265 | 5,325,000 | 0.44% | ||
| 40 | Bank of New York Mellon Corp | 147,053 | 5,283,000 | 0.44% | ||
| 41 | Rock Springs Capital Management LP | 147,000 | 5,280,000 | 0.44% | ||
| 42 | WELLS FARGO & COMPANY/MN | 144,661 | 5,197,000 | 0.43% | ||
| 43 | PRICE T ROWE ASSOCIATES INC /MD/ | 143,200 | 5,144,000 | 0.43% | ||
| 44 | RENAISSANCE TECHNOLOGIES LLC | 140,700 | 5,054,000 | 0.42% | ||
| 45 | RUSSELL FRANK CO/ | 134,266 | 4,823,000 | 0.40% | ||
| 46 | CREDIT SUISSE AG/ | 124,239 | 4,463,000 | 0.37% | ||
| 47 | BELLEVUE ASSET MANAGEMENT AG | 120,000 | 4,310,000 | 0.36% | ||
| 48 | DEUTSCHE BANK AG\ | 118,478 | 4,254,000 | 0.35% | ||
| 49 | AHL Partners LLP | 109,364 | 3,929,000 | 0.33% | ||
| 50 | DUPONT CAPITAL MANAGEMENT CORP | 103,168 | 3,706,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
