| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,758,130 | 35,866,000 | 16.39% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 861,513 | 17,575,000 | 8.03% | ||
| 3 | Point72 Asset Management, L.P. | 719,100 | 14,670,000 | 6.70% | ||
| 4 | JENNISON ASSOCIATES LLC | 677,610 | 13,823,000 | 6.32% | ||
| 5 | Visium Asset Management, LP | 475,000 | 9,690,000 | 4.43% | ||
| 6 | BlackRock Fund Advisors | 446,431 | 9,107,000 | 4.16% | ||
| 7 | PUTNAM INVESTMENTS LLC | 413,908 | 8,444,000 | 3.86% | ||
| 8 | VANGUARD GROUP INC | 357,017 | 7,283,000 | 3.33% | ||
| 9 | TFS CAPITAL LLC | 292,636 | 5,970,000 | 2.73% | ||
| 10 | EverPoint Asset Management, LLC | 292,200 | 5,961,000 | 2.72% | ||
| 11 | EVENTIDE ASSET MANAGEMENT, LLC | 279,100 | 5,694,000 | 2.60% | ||
| 12 | Ridgeback Capital Investments L.P. | 246,005 | 5,019,000 | 2.29% | ||
| 13 | RA CAPITAL MANAGEMENT, L.P. | 236,059 | 4,816,000 | 2.20% | ||
| 14 | Numeric Investors LLC | 226,689 | 4,624,000 | 2.11% | ||
| 15 | EMERALD MUTUAL FUND ADVISERS TRUST | 205,401 | 4,190,000 | 1.92% | ||
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | 189,981 | 3,876,000 | 1.77% | ||
| 17 | EMERALD ADVISERS, LLC | 184,610 | 3,766,000 | 1.72% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 183,347 | 3,740,000 | 1.71% | ||
| 19 | JPMORGAN CHASE & CO | 174,512 | 3,560,000 | 1.63% | ||
| 20 | DAFNA Capital Management LLC | 157,192 | 3,207,000 | 1.47% | ||
| 21 | Iguana Healthcare Management, LLC | 150,000 | 3,060,000 | 1.40% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 142,592 | 2,909,000 | 1.33% | ||
| 23 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 130,926 | 2,670,000 | 1.22% | ||
| 24 | PANAGORA ASSET MANAGEMENT INC | 128,863 | 2,629,000 | 1.20% | ||
| 25 | Private Capital Advisors, Inc. | 128,377 | 2,619,000 | 1.20% | ||
| 26 | Invesco Ltd. | 125,475 | 2,560,000 | 1.17% | ||
| 27 | STATE STREET CORP | 113,985 | 2,325,000 | 1.06% | ||
| 28 | AQR CAPITAL MANAGEMENT LLC | 94,404 | 1,926,000 | 0.88% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 92,290 | 1,882,000 | 0.86% | ||
| 30 | NORTHERN TRUST CORP | 91,255 | 1,861,000 | 0.85% | ||
| 31 | ACADIAN ASSET MANAGEMENT LLC | 88,688 | 1,811,000 | 0.83% | ||
| 32 | Spark Investment Management LLC | 81,500 | 1,662,000 | 0.76% | ||
| 33 | DEUTSCHE BANK AG\ | 75,728 | 1,543,000 | 0.71% | ||
| 34 | RUSSELL FRANK CO/ | 75,999 | 1,541,000 | 0.70% | ||
| 35 | C WorldWide Group Holding A/S | 70,000 | 1,428,000 | 0.65% | ||
| 36 | GLOBEFLEX CAPITAL L P | 58,300 | 1,189,000 | 0.54% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 57,851 | 1,180,000 | 0.54% | ||
| 38 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 48,550 | 990,000 | 0.45% | ||
| 39 | CITADEL ADVISORS LLC | 43,103 | 879,000 | 0.40% | ||
| 40 | Bank of New York Mellon Corp | 41,733 | 851,000 | 0.39% | ||
| 41 | BlackRock Investment Management, LLC | 29,711 | 606,000 | 0.28% | ||
| 42 | DEERE & CO | 28,506 | 582,000 | 0.27% | ||
| 43 | ALPS ADVISORS INC | 23,717 | 484,000 | 0.22% | ||
| 44 | D. E. Shaw & Co., Inc. | 23,183 | 473,000 | 0.22% | ||
| 45 | BANK OF MONTREAL /CAN/ | 23,081 | 471,000 | 0.22% | ||
| 46 | Airain ltd | 20,335 | 415,000 | 0.19% | ||
| 47 | RENAISSANCE TECHNOLOGIES LLC | 20,000 | 408,000 | 0.19% | ||
| 48 | A.R.T. Advisors, LLC | 19,460 | 396,000 | 0.18% | ||
| 49 | MARSHALL WACE, LLP | 19,425 | 396,000 | 0.18% | ||
| 50 | ELLINGTON MANAGEMENT GROUP LLC | 19,063 | 389,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
