| 1 |
FMR LLC |
1,335,389 |
20,485,000 |
14.30% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
1,041,823 |
15,982,000 |
11.16% |
|
|
| 3 |
Point72 Asset Management, L.P. |
964,114 |
14,790,000 |
10.32% |
|
|
| 4 |
Visium Asset Management, LP |
960,000 |
14,726,000 |
10.28% |
|
|
| 5 |
ACUTA CAPITAL PARTNERS, LLC |
748,000 |
11,474,000 |
8.01% |
|
|
| 6 |
Private Capital Advisors, Inc. |
397,757 |
6,102,000 |
4.26% |
|
|
| 7 |
PUTNAM INVESTMENTS LLC |
394,487 |
6,052,000 |
4.22% |
|
|
| 8 |
EverPoint Asset Management, LLC |
324,369 |
4,976,000 |
3.47% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
312,648 |
4,796,000 |
3.35% |
|
|
| 10 |
PERCEPTIVE ADVISORS LLC |
300,922 |
4,616,000 |
3.22% |
|
|
| 11 |
BlackRock Fund Advisors |
229,869 |
3,526,000 |
2.46% |
|
|
| 12 |
VANGUARD GROUP INC |
225,672 |
3,462,000 |
2.42% |
|
|
| 13 |
EVENTIDE ASSET MANAGEMENT, LLC |
205,500 |
3,152,000 |
2.20% |
|
|
| 14 |
SPHERA FUNDS MANAGEMENT LTD. |
200,124 |
3,070,000 |
2.14% |
|
|
| 15 |
PRICE T ROWE ASSOCIATES INC /MD/ |
189,981 |
2,914,000 |
2.03% |
|
|
| 16 |
SABBY MANAGEMENT, LLC |
172,427 |
2,645,000 |
1.85% |
|
|
| 17 |
ALTRINSIC GLOBAL ADVISORS LLC |
164,000 |
2,516,000 |
1.76% |
|
|
| 18 |
JPMORGAN CHASE & CO |
159,800 |
2,452,000 |
1.71% |
|
|
| 19 |
DAFNA Capital Management LLC |
157,192 |
2,411,000 |
1.68% |
|
|
| 20 |
Iguana Healthcare Management, LLC |
150,000 |
2,301,000 |
1.61% |
|
|
| 21 |
STATE STREET CORP |
69,716 |
1,070,000 |
0.75% |
|
|
| 22 |
TFS CAPITAL LLC |
64,537 |
990,000 |
0.69% |
|
|
| 23 |
PANAGORA ASSET MANAGEMENT INC |
64,455 |
989,000 |
0.69% |
|
|
| 24 |
NORTHERN TRUST CORP |
60,149 |
923,000 |
0.64% |
|
|
| 25 |
BlackRock Institutional Trust Company, N.A. |
52,995 |
813,000 |
0.57% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
47,149 |
723,000 |
0.50% |
|
|
| 27 |
Bank of New York Mellon Corp |
32,851 |
503,000 |
0.35% |
|
|
| 28 |
BlackRock Investment Management, LLC |
30,042 |
461,000 |
0.32% |
|
|
| 29 |
Nuveen Asset Management, LLC |
26,044 |
400,000 |
0.28% |
|
|
| 30 |
BANK OF MONTREAL /CAN/ |
23,125 |
355,000 |
0.25% |
|
|
| 31 |
DEUTSCHE BANK AG\ |
22,113 |
339,000 |
0.24% |
|
|
| 32 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
21,081 |
323,000 |
0.23% |
|
|
| 33 |
Fortress Investment Group LLC |
19,070 |
293,000 |
0.20% |
|
|
| 34 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
18,000 |
276,000 |
0.19% |
|
|
| 35 |
Cormorant Asset Management, LP |
17,110 |
262,000 |
0.18% |
|
|
| 36 |
ALPS ADVISORS INC |
16,299 |
250,000 |
0.17% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
16,063 |
246,000 |
0.17% |
|
|
| 38 |
TEACHERS ADVISORS, LLC |
12,636 |
194,000 |
0.14% |
|
|
| 39 |
ARDSLEY ADVISORY PARTNERS LP |
12,467 |
191,000 |
0.13% |
|
|
| 40 |
TUDOR INVESTMENT CORP ET AL |
11,044 |
169,000 |
0.12% |
|
|
| 41 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
11,000 |
169,000 |
0.12% |
|
|
| 42 |
J.P. Turner & Co Capital Mnagement, LLC |
10,500 |
162,000 |
0.11% |
|
|
| 43 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,000 |
123,000 |
0.09% |
|
|
| 44 |
Nationwide Fund Advisors |
7,863 |
121,000 |
0.08% |
|
|
| 45 |
MORGAN STANLEY |
7,109 |
109,000 |
0.08% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,154 |
79,062 |
0.06% |
|
|
| 47 |
CITIGROUP INC |
4,729 |
73,000 |
0.05% |
|
|
| 48 |
BLACKROCK ADVISORS LLC |
4,257 |
65,000 |
0.05% |
|
|
| 49 |
BANK OF AMERICA CORP /DE/ |
3,391 |
52,000 |
0.04% |
|
|
| 50 |
US BANCORP \DE\ |
1,387 |
21,000 |
0.01% |
|
|
