| 1 |
FMR LLC |
1,350,796 |
17,749,000 |
14.50% |
|
|
| 2 |
Point72 Asset Management, L.P. |
1,000,000 |
13,140,000 |
10.73% |
|
|
| 3 |
Visium Asset Management, LP |
944,700 |
12,413,000 |
10.14% |
|
|
| 4 |
JENNISON ASSOCIATES LLC |
674,362 |
8,861,000 |
7.24% |
|
|
| 5 |
EverPoint Asset Management, LLC |
575,000 |
7,556,000 |
6.17% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
850,992 |
5,591,000 |
4.57% |
|
|
| 7 |
Private Capital Advisors, Inc. |
422,757 |
5,555,000 |
4.54% |
|
|
| 8 |
PUTNAM INVESTMENTS LLC |
396,680 |
5,213,000 |
4.26% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
348,629 |
4,581,000 |
3.74% |
|
|
| 10 |
VANGUARD GROUP INC |
279,071 |
3,667,000 |
3.00% |
|
|
| 11 |
ALPS ADVISORS INC |
25,811 |
3,392,000 |
2.77% |
|
|
| 12 |
EVENTIDE ASSET MANAGEMENT, LLC |
250,500 |
3,292,000 |
2.69% |
|
|
| 13 |
BlackRock Fund Advisors |
226,929 |
2,982,000 |
2.44% |
|
|
| 14 |
ACUTA CAPITAL PARTNERS, LLC |
221,138 |
2,906,000 |
2.37% |
|
|
| 15 |
JPMORGAN CHASE & CO |
199,200 |
2,617,000 |
2.14% |
|
|
| 16 |
PRICE T ROWE ASSOCIATES INC /MD/ |
189,981 |
2,496,000 |
2.04% |
|
|
| 17 |
DAFNA Capital Management LLC |
157,192 |
2,066,000 |
1.69% |
|
|
| 18 |
Iguana Healthcare Management, LLC |
125,000 |
1,643,000 |
1.34% |
|
|
| 19 |
SABBY MANAGEMENT, LLC |
124,000 |
1,629,000 |
1.33% |
|
|
| 20 |
RA CAPITAL MANAGEMENT, L.P. |
121,100 |
1,591,000 |
1.30% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
120,246 |
1,580,000 |
1.29% |
|
|
| 22 |
NORTHERN TRUST CORP |
89,203 |
1,172,000 |
0.96% |
|
|
| 23 |
Spark Investment Management LLC |
85,600 |
1,123,000 |
0.92% |
|
|
| 24 |
PANAGORA ASSET MANAGEMENT INC |
82,414 |
1,083,000 |
0.88% |
|
|
| 25 |
STATE STREET CORP |
74,476 |
978,000 |
0.80% |
|
|
| 26 |
DEUTSCHE BANK AG\ |
72,987 |
958,000 |
0.78% |
|
|
| 27 |
GEODE CAPITAL MANAGEMENT, LLC |
61,179 |
803,000 |
0.66% |
|
|
| 28 |
TFS CAPITAL LLC |
59,194 |
778,000 |
0.64% |
|
|
| 29 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
48,550 |
638,000 |
0.52% |
|
|
| 30 |
Bank of New York Mellon Corp |
35,429 |
465,000 |
0.38% |
|
|
| 31 |
BlackRock Investment Management, LLC |
29,656 |
390,000 |
0.32% |
|
|
| 32 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
27,491 |
361,000 |
0.29% |
|
|
| 33 |
J.P. Turner & Co Capital Mnagement, LLC |
23,900 |
315,000 |
0.26% |
|
|
| 34 |
BANK OF MONTREAL /CAN/ |
21,855 |
287,000 |
0.23% |
|
|
| 35 |
Numeric Investors LLC |
20,900 |
275,000 |
0.22% |
|
|
| 36 |
Fortress Investment Group LLC |
19,070 |
251,000 |
0.21% |
|
|
| 37 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
18,000 |
237,000 |
0.19% |
|
|
| 38 |
Cormorant Asset Management, LP |
17,110 |
225,000 |
0.18% |
|
|
| 39 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
15,963 |
210,000 |
0.17% |
|
|
| 40 |
A.R.T. Advisors, LLC |
13,956 |
183,000 |
0.15% |
|
|
| 41 |
Connor, Clark & Lunn Investment Management Ltd. |
13,050 |
171,000 |
0.14% |
|
|
| 42 |
TEACHERS ADVISORS, LLC |
12,636 |
166,000 |
0.14% |
|
|
| 43 |
ARDSLEY ADVISORY PARTNERS LP |
12,467 |
164,000 |
0.13% |
|
|
| 44 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,000 |
105,000 |
0.09% |
|
|
| 45 |
CITIGROUP INC |
7,651 |
101,000 |
0.08% |
|
|
| 46 |
Nationwide Fund Advisors |
7,463 |
98,000 |
0.08% |
|
|
| 47 |
MORGAN STANLEY |
6,343 |
84,000 |
0.07% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,160 |
68,000 |
0.06% |
|
|
| 49 |
BLACKROCK ADVISORS LLC |
4,222 |
55,000 |
0.04% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
3,765 |
50,000 |
0.04% |
|
|
