| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | INTERWEST VENTURE MANAGEMENT CO | 1,452,216 | 10,021,000 | 13.47% | ||
| 2 | BlackRock Finance, Inc. | 1,007,373 | 6,951,000 | 9.34% | ||
| 3 | FMR LLC | 837,697 | 5,780,000 | 7.77% | ||
| 4 | ACADIAN ASSET MANAGEMENT LLC | 714,050 | 4,927,000 | 6.62% | ||
| 5 | Numeric Investors LLC | 631,289 | 4,356,000 | 5.85% | ||
| 6 | VANGUARD GROUP INC | 539,349 | 3,722,000 | 5.00% | ||
| 7 | AJO, LP | 469,970 | 3,243,000 | 4.36% | ||
| 8 | DAFNA Capital Management LLC | 411,000 | 2,836,000 | 3.81% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 274,618 | 1,895,000 | 2.55% | ||
| 10 | STATE STREET CORP | 274,811 | 1,893,000 | 2.54% | ||
| 11 | PANAGORA ASSET MANAGEMENT INC | 254,529 | 1,756,000 | 2.36% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 252,013 | 1,739,000 | 2.34% | ||
| 13 | PRICE T ROWE ASSOCIATES INC /MD/ | 190,016 | 1,311,000 | 1.76% | ||
| 14 | AQR CAPITAL MANAGEMENT LLC | 187,066 | 1,290,000 | 1.73% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 184,100 | 1,270,000 | 1.71% | ||
| 16 | MORGAN STANLEY | 168,256 | 1,162,000 | 1.56% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 161,831 | 1,116,000 | 1.50% | ||
| 18 | OXFORD ASSET MANAGEMENT LLP | 160,953 | 1,111,000 | 1.49% | ||
| 19 | DIMENSIONAL FUND ADVISORS LP | 159,883 | 1,103,000 | 1.48% | ||
| 20 | GSA CAPITAL PARTNERS LLP | 155,200 | 1,071,000 | 1.44% | ||
| 21 | PRUDENTIAL FINANCIAL INC | 155,210 | 1,071,000 | 1.44% | ||
| 22 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 135,000 | 932,000 | 1.25% | ||
| 23 | NORTHERN TRUST CORP | 134,728 | 930,000 | 1.25% | ||
| 24 | DEUTSCHE BANK AG\ | 127,783 | 881,000 | 1.18% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 109,506 | 756,000 | 1.02% | ||
| 26 | Walleye Trading LLC | 107,700 | 743,000 | 1.00% | ||
| 27 | STRS OHIO | 85,800 | 592,000 | 0.80% | ||
| 28 | RUSSELL INVESTMENTS GROUP, LTD. | 77,710 | 535,000 | 0.72% | ||
| 29 | Granite Investment Partners, LLC | 77,088 | 532,000 | 0.72% | ||
| 30 | Iguana Healthcare Management, LLC | 75,000 | 518,000 | 0.70% | ||
| 31 | ALGERT GLOBAL LLC | 73,335 | 506,000 | 0.68% | ||
| 32 | Nine Chapters Capital Management LLC | 63,700 | 440,000 | 0.59% | ||
| 33 | Connor, Clark & Lunn Investment Management Ltd. | 63,475 | 438,000 | 0.59% | ||
| 34 | ClariVest Asset Management LLC | 60,562 | 418,000 | 0.56% | ||
| 35 | TFS CAPITAL LLC | 60,015 | 414,000 | 0.56% | ||
| 36 | Bank of New York Mellon Corp | 57,924 | 400,000 | 0.54% | ||
| 37 | BANK OF MONTREAL /CAN/ | 56,732 | 392,000 | 0.53% | ||
| 38 | AMERICAN CENTURY COMPANIES INC | 56,143 | 387,000 | 0.52% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 50,423 | 348,000 | 0.47% | ||
| 40 | Allianz Asset Management GmbH | 40,820 | 282,000 | 0.38% | ||
| 41 | DUPONT CAPITAL MANAGEMENT CORP | 36,509 | 252,000 | 0.34% | ||
| 42 | PRELUDE CAPITAL MANAGEMENT, LLC | 34,900 | 241,000 | 0.32% | ||
| 43 | PDT Partners, LLC | 33,100 | 228,000 | 0.31% | ||
| 44 | CREDIT SUISSE AG/ | 27,110 | 187,000 | 0.25% | ||
| 45 | JACOBS LEVY EQUITY MANAGEMENT, INC | 26,800 | 185,000 | 0.25% | ||
| 46 | FEDERATION DES CAISSES DESJARDINS DU QUEBEC | 26,297 | 181,450 | 0.24% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,100 | 180,000 | 0.24% | Put | |
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,519 | 176,000 | 0.24% | ||
| 49 | TEACHERS ADVISORS, LLC | 22,692 | 157,000 | 0.21% | ||
| 50 | Invesco Ltd. | 21,990 | 152,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
