| 1 |
BVF INC/IL |
44,796,940 |
23,805,000 |
40.92% |
|
|
| 2 |
FMR LLC |
23,782,248 |
12,638,000 |
21.72% |
|
|
| 3 |
VANGUARD GROUP INC |
8,327,849 |
4,425,000 |
7.61% |
|
|
| 4 |
BlackRock Fund Advisors |
6,043,618 |
3,212,000 |
5.52% |
|
|
| 5 |
BlackRock Institutional Trust Company, N.A. |
5,684,666 |
3,021,000 |
5.19% |
|
|
| 6 |
STONEPINE CAPITAL MANAGEMENT, LLC |
3,743,340 |
1,989,000 |
3.42% |
|
|
| 7 |
STATE STREET CORP |
2,730,387 |
1,452,000 |
2.50% |
|
|
| 8 |
NORTHERN TRUST CORP |
2,381,760 |
1,265,000 |
2.17% |
|
|
| 9 |
GEODE CAPITAL MANAGEMENT, LLC |
1,321,080 |
702,000 |
1.21% |
|
|
| 10 |
MILLENNIUM MANAGEMENT LLC |
923,678 |
491,000 |
0.84% |
|
|
| 11 |
Bank of New York Mellon Corp |
873,042 |
464,000 |
0.80% |
|
|
| 12 |
BlackRock Investment Management, LLC |
847,000 |
450,000 |
0.77% |
|
|
| 13 |
Alyeska Investment Group, L.P. |
773,469 |
411,000 |
0.71% |
|
|
| 14 |
JANE STREET GROUP, LLC |
701,579 |
373,000 |
0.64% |
|
|
| 15 |
UNITED CAPITAL FINANCIAL ADVISORS, LLC |
526,210 |
279,000 |
0.48% |
|
|
| 16 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
488,611 |
260,000 |
0.45% |
|
|
| 17 |
COMMERZBANK AKTIENGESELLSCHAFT /FI |
421,460 |
224,000 |
0.39% |
|
|
| 18 |
WASHINGTON TRUST Co |
410,616 |
218,000 |
0.37% |
|
|
| 19 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
393,700 |
210,000 |
0.36% |
|
|
| 20 |
Swiss National Bank |
360,150 |
185,000 |
0.32% |
|
|
| 21 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
343,900 |
183,000 |
0.31% |
|
|
| 22 |
CREDIT SUISSE AG/ |
218,698 |
117,000 |
0.20% |
|
|
| 23 |
RHUMBLINE ADVISERS |
195,545 |
104,000 |
0.18% |
|
|
| 24 |
CITIGROUP INC |
191,817 |
102,000 |
0.18% |
|
|
| 25 |
TUDOR INVESTMENT CORP ET AL |
188,500 |
100,000 |
0.17% |
|
|
| 26 |
SG Americas Securities, LLC |
157,960 |
84,000 |
0.14% |
|
|
| 27 |
NEW YORK STATE COMMON RETIREMENT FUND |
150,400 |
80,000 |
0.14% |
|
|
| 28 |
Nationwide Fund Advisors |
148,412 |
79,000 |
0.14% |
|
|
| 29 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
145,598 |
75,000 |
0.13% |
|
|
| 30 |
ALLIANCEBERNSTEIN L.P. |
139,900 |
74,000 |
0.13% |
|
|
| 31 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
131,920 |
70,000 |
0.12% |
|
|
| 32 |
CITADEL ADVISORS LLC |
129,866 |
69,000 |
0.12% |
|
|
| 33 |
AMERICAN INTERNATIONAL GROUP, INC. |
128,341 |
68,000 |
0.12% |
|
|
| 34 |
GOLDMAN SACHS GROUP INC |
120,480 |
64,000 |
0.11% |
|
|
| 35 |
DEUTSCHE BANK AG\ |
122,121 |
63,000 |
0.11% |
|
|
| 36 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
112,900 |
60,000 |
0.10% |
|
|
| 37 |
VOYA INVESTMENT MANAGEMENT LLC |
101,260 |
54,000 |
0.09% |
|
|
| 38 |
BLACKROCK ADVISORS LLC |
92,293 |
49,000 |
0.08% |
|
|
| 39 |
Creative Planning |
91,741 |
49,000 |
0.08% |
|
|
| 40 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
87,300 |
46,000 |
0.08% |
Call |
|
| 41 |
AQR CAPITAL MANAGEMENT LLC |
80,700 |
43,000 |
0.07% |
|
|
| 42 |
BAYESIAN CAPITAL MANAGEMENT, LP |
76,100 |
40,000 |
0.07% |
|
|
| 43 |
WELLS FARGO & COMPANY/MN |
68,704 |
37,000 |
0.06% |
|
|
| 44 |
GUGGENHEIM CAPITAL LLC |
68,146 |
36,000 |
0.06% |
|
|
| 45 |
MORGAN STANLEY |
66,155 |
35,000 |
0.06% |
|
|
| 46 |
JPMORGAN CHASE & CO |
57,107 |
30,000 |
0.05% |
|
|
| 47 |
JW Asset Management, LLC |
50,254 |
27,000 |
0.05% |
|
|
| 48 |
BlackRock Group LTD |
49,910 |
26,000 |
0.04% |
|
|
| 49 |
PANAGORA ASSET MANAGEMENT INC |
45,270 |
24,000 |
0.04% |
|
|
| 50 |
PRINCIPAL FINANCIAL GROUP INC |
40,323 |
21,000 |
0.04% |
|
|
