| 1 |
BVF INC/IL |
44,796,940 |
16,767,000 |
62.90% |
|
|
| 2 |
VANGUARD GROUP INC |
7,362,722 |
2,756,000 |
10.34% |
|
|
| 3 |
FMR LLC |
4,800,000 |
1,797,000 |
6.74% |
|
|
| 4 |
BlackRock Institutional Trust Company, N.A. |
3,459,402 |
1,295,000 |
4.86% |
|
|
| 5 |
RENAISSANCE TECHNOLOGIES LLC |
1,966,847 |
736,000 |
2.76% |
|
|
| 6 |
GOLDMAN SACHS GROUP INC |
1,375,394 |
515,000 |
1.93% |
|
|
| 7 |
GEODE CAPITAL MANAGEMENT, LLC |
1,133,041 |
424,000 |
1.59% |
|
|
| 8 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
919,200 |
344,000 |
1.29% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
686,300 |
257,000 |
0.96% |
|
|
| 10 |
DEUTSCHE BANK AG\ |
546,604 |
204,000 |
0.77% |
|
|
| 11 |
UNITED CAPITAL FINANCIAL ADVISORS, LLC |
526,210 |
195,000 |
0.73% |
|
|
| 12 |
BLAIR WILLIAM & CO/IL |
511,984 |
192,000 |
0.72% |
|
|
| 13 |
WASHINGTON TRUST Co |
410,616 |
154,000 |
0.58% |
|
|
| 14 |
COMMERZBANK AKTIENGESELLSCHAFT /FI |
379,958 |
142,000 |
0.53% |
|
|
| 15 |
NORTHERN TRUST CORP |
370,581 |
139,000 |
0.52% |
|
|
| 16 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
312,100 |
117,000 |
0.44% |
|
|
| 17 |
Bank of New York Mellon Corp |
230,491 |
86,000 |
0.32% |
|
|
| 18 |
PANAGORA ASSET MANAGEMENT INC |
127,230 |
48,000 |
0.18% |
|
|
| 19 |
STATE STREET CORP |
110,544 |
42,000 |
0.16% |
|
|
| 20 |
EMERALD ACQUISITION LTD. |
99,300 |
37,000 |
0.14% |
|
|
| 21 |
MORGAN STANLEY |
99,378 |
37,000 |
0.14% |
|
|
| 22 |
UBS Group AG |
92,161 |
34,000 |
0.13% |
|
|
| 23 |
Creative Planning |
91,741 |
34,000 |
0.13% |
|
|
| 24 |
Tower Research Capital LLC (TRC) |
82,880 |
31,000 |
0.12% |
|
|
| 25 |
AQR CAPITAL MANAGEMENT LLC |
80,700 |
30,000 |
0.11% |
|
|
| 26 |
GUGGENHEIM CAPITAL LLC |
63,017 |
24,000 |
0.09% |
|
|
| 27 |
FIRST NEW YORK SECURITIES LLC /NY |
53,100 |
19,875 |
0.07% |
|
|
| 28 |
OXFORD ASSET MANAGEMENT LLP |
49,443 |
19,000 |
0.07% |
|
|
| 29 |
JW Asset Management, LLC |
50,254 |
19,000 |
0.07% |
|
|
| 30 |
CREDIT SUISSE AG/ |
44,191 |
16,000 |
0.06% |
|
|
| 31 |
BlackRock Fund Advisors |
42,164 |
16,000 |
0.06% |
|
|
| 32 |
TWO SIGMA SECURITIES, LLC |
37,284 |
14,000 |
0.05% |
|
|
| 33 |
D. E. Shaw & Co., Inc. |
32,560 |
12,000 |
0.05% |
|
|
| 34 |
Virtu KCG Holdings LLC |
29,916 |
11,000 |
0.04% |
|
|
| 35 |
JANE STREET GROUP, LLC |
30,607 |
11,000 |
0.04% |
|
|
| 36 |
BLACKROCK ADVISORS LLC |
26,414 |
10,000 |
0.04% |
|
|
| 37 |
Nine Chapters Capital Management LLC |
24,900 |
9,000 |
0.03% |
|
|
| 38 |
PRELUDE CAPITAL MANAGEMENT, LLC |
24,900 |
9,000 |
0.03% |
|
|
| 39 |
ACADIAN ASSET MANAGEMENT LLC |
21,612 |
8,000 |
0.03% |
|
|
| 40 |
BOKF, NA |
15,000 |
6,000 |
0.02% |
|
|
| 41 |
CITADEL ADVISORS LLC |
12,600 |
5,000 |
0.02% |
Call |
|
| 42 |
Janney Montgomery Scott LLC |
13,716 |
5,000 |
0.02% |
|
|
| 43 |
GROUP ONE TRADING LLC |
10,394 |
4,000 |
0.02% |
|
|
| 44 |
Commonwealth Equity Services, Inc |
10,113 |
4,000 |
0.02% |
|
|
| 45 |
Connor, Clark & Lunn Investment Management Ltd. |
10,100 |
4,000 |
0.02% |
|
|
| 46 |
Compagnie Lombard Odier SCmA |
8,000 |
3,000 |
0.01% |
|
|
| 47 |
Financial Architects, Inc |
5,100 |
2,000 |
0.01% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
5,438 |
2,000 |
0.01% |
|
|
| 49 |
CUTLER GROUP LLC / CA |
7,840 |
2,000 |
0.01% |
|
|
| 50 |
BARCLAYS PLC |
5,217 |
2,000 |
0.01% |
|
|
