| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 44,796,940 | 15,231,000 | 55.05% | ||
| 2 | FMR LLC | 11,445,259 | 3,891,000 | 14.06% | ||
| 3 | VANGUARD GROUP INC | 7,638,471 | 2,598,000 | 9.39% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 3,459,402 | 1,176,000 | 4.25% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 2,861,842 | 973,000 | 3.52% | ||
| 6 | GOLDMAN SACHS GROUP INC | 1,490,528 | 507,000 | 1.83% | ||
| 7 | JACOBS LEVY EQUITY MANAGEMENT, INC | 1,168,900 | 397,000 | 1.43% | ||
| 8 | GEODE CAPITAL MANAGEMENT, LLC | 1,131,581 | 384,000 | 1.39% | ||
| 9 | Paloma Partners Management Co | 859,915 | 292,000 | 1.06% | ||
| 10 | Alyeska Investment Group, L.P. | 789,487 | 268,000 | 0.97% | ||
| 11 | BLAIR WILLIAM & CO/IL | 511,984 | 174,000 | 0.63% | ||
| 12 | CREDIT SUISSE AG/ | 463,792 | 158,000 | 0.57% | ||
| 13 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 425,986 | 145,000 | 0.52% | ||
| 14 | WASHINGTON TRUST Co | 410,616 | 140,000 | 0.51% | ||
| 15 | NORTHERN TRUST CORP | 370,907 | 126,000 | 0.46% | ||
| 16 | JANE STREET GROUP, LLC | 362,162 | 123,000 | 0.44% | ||
| 17 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 333,500 | 113,000 | 0.41% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 315,544 | 107,000 | 0.39% | ||
| 19 | Bank of New York Mellon Corp | 270,802 | 92,000 | 0.33% | ||
| 20 | LMR Partners LLP | 235,048 | 80,000 | 0.29% | ||
| 21 | EMERALD ACQUISITION LTD. | 212,900 | 72,000 | 0.26% | ||
| 22 | Alpine Global Management, LLC | 175,588 | 60,000 | 0.22% | ||
| 23 | Laurion Capital Management LP | 161,312 | 55,000 | 0.20% | ||
| 24 | Virtu KCG Holdings LLC | 136,911 | 47,000 | 0.17% | ||
| 25 | DEUTSCHE BANK AG\ | 121,795 | 41,000 | 0.15% | ||
| 26 | STATE STREET CORP | 114,089 | 38,000 | 0.14% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 100,213 | 34,000 | 0.12% | ||
| 28 | Squarepoint Ops LLC | 93,700 | 32,000 | 0.12% | ||
| 29 | Creative Planning | 91,741 | 31,000 | 0.11% | ||
| 30 | Tower Research Capital LLC (TRC) | 89,386 | 30,000 | 0.11% | ||
| 31 | OXFORD ASSET MANAGEMENT LLP | 82,300 | 28,000 | 0.10% | ||
| 32 | BlackRock Fund Advisors | 80,061 | 27,000 | 0.10% | ||
| 33 | AQR CAPITAL MANAGEMENT LLC | 80,700 | 27,000 | 0.10% | ||
| 34 | GUGGENHEIM CAPITAL LLC | 63,588 | 22,000 | 0.08% | ||
| 35 | MORGAN STANLEY | 50,574 | 17,000 | 0.06% | ||
| 36 | JW Asset Management, LLC | 50,254 | 17,000 | 0.06% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 43,765 | 15,000 | 0.05% | ||
| 38 | PANAGORA ASSET MANAGEMENT INC | 45,270 | 15,000 | 0.05% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,900 | 14,000 | 0.05% | Call | |
| 40 | BARCLAYS PLC | 32,807 | 11,000 | 0.04% | ||
| 41 | BLACKROCK ADVISORS LLC | 26,414 | 9,000 | 0.03% | ||
| 42 | BAYESIAN CAPITAL MANAGEMENT, LP | 16,200 | 6,000 | 0.02% | ||
| 43 | First Heartland Consultants, Inc. | 14,924 | 5,000 | 0.02% | ||
| 44 | UBS Group AG | 14,247 | 5,000 | 0.02% | ||
| 45 | D. E. Shaw & Co., Inc. | 13,260 | 5,000 | 0.02% | ||
| 46 | OLD MISSION CAPITAL LLC | 13,368 | 5,000 | 0.02% | ||
| 47 | JPMORGAN CHASE & CO | 13,123 | 4,000 | 0.01% | ||
| 48 | GROUP ONE TRADING LLC | 10,394 | 4,000 | 0.01% | ||
| 49 | Commonwealth Equity Services, Inc | 10,113 | 3,000 | 0.01% | ||
| 50 | Connor, Clark & Lunn Investment Management Ltd. | 10,100 | 3,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
