| 1 |
BVF INC/IL |
10,000,000 |
14,600,000 |
18.28% |
|
|
| 2 |
FMR LLC |
9,753,954 |
14,241,000 |
17.83% |
|
|
| 3 |
VANGUARD GROUP INC |
5,934,414 |
8,664,000 |
10.85% |
|
|
| 4 |
BlackRock Institutional Trust Company, N.A. |
4,640,536 |
6,775,000 |
8.48% |
|
|
| 5 |
BlackRock Fund Advisors |
4,290,232 |
6,264,000 |
7.84% |
|
|
| 6 |
STATE STREET CORP |
2,241,148 |
3,270,000 |
4.09% |
|
|
| 7 |
NORTHERN TRUST CORP |
1,737,611 |
2,537,000 |
3.18% |
|
|
| 8 |
Candriam S.C.A. |
1,515,000 |
2,212,000 |
2.77% |
|
|
| 9 |
Lombard Odier Asset Management (USA) Corp |
1,303,135 |
1,903,000 |
2.38% |
|
|
| 10 |
DEUTSCHE BANK AG\ |
1,109,865 |
1,618,000 |
2.03% |
|
|
| 11 |
TEACHERS ADVISORS, LLC |
1,064,246 |
1,554,000 |
1.95% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
988,338 |
1,442,000 |
1.81% |
|
|
| 13 |
COMMERZBANK AKTIENGESELLSCHAFT /FI |
811,363 |
1,185,000 |
1.48% |
|
|
| 14 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
793,676 |
1,159,000 |
1.45% |
|
|
| 15 |
Bank of New York Mellon Corp |
638,003 |
932,000 |
1.17% |
|
|
| 16 |
BlackRock Investment Management, LLC |
570,058 |
832,000 |
1.04% |
|
|
| 17 |
MILLENNIUM MANAGEMENT LLC |
511,976 |
747,000 |
0.94% |
|
|
| 18 |
UNITED CAPITAL FINANCIAL ADVISORS, LLC |
490,999 |
717,000 |
0.90% |
|
|
| 19 |
Consonance Capital Management LP |
460,000 |
672,000 |
0.84% |
|
|
| 20 |
WASHINGTON TRUST Co |
410,616 |
599,000 |
0.75% |
|
|
| 21 |
SMITH ASSET MANAGEMENT GROUP LP |
409,070 |
597,000 |
0.75% |
|
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
364,700 |
532,000 |
0.67% |
|
|
| 23 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
340,500 |
497,000 |
0.62% |
Call |
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
299,489 |
437,000 |
0.55% |
|
|
| 25 |
GOLDMAN SACHS GROUP INC |
271,582 |
396,000 |
0.50% |
|
|
| 26 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
266,115 |
388,000 |
0.49% |
|
|
| 27 |
Swiss National Bank |
253,500 |
370,000 |
0.46% |
|
|
| 28 |
JANE STREET GROUP, LLC |
198,031 |
289,000 |
0.36% |
|
|
| 29 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
190,800 |
279,000 |
0.35% |
|
|
| 30 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
172,000 |
251,000 |
0.31% |
Put |
|
| 31 |
A.R.T. Advisors, LLC |
166,744 |
243,000 |
0.30% |
|
|
| 32 |
ALLIANCEBERNSTEIN L.P. |
156,700 |
229,000 |
0.29% |
|
|
| 33 |
NEW YORK STATE COMMON RETIREMENT FUND |
150,400 |
220,000 |
0.28% |
|
|
| 34 |
RHUMBLINE ADVISERS |
145,885 |
213,000 |
0.27% |
|
|
| 35 |
BARCLAYS PLC |
189,181 |
189,000 |
0.24% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
110,033 |
161,000 |
0.20% |
|
|
| 37 |
Nationwide Fund Advisors |
108,106 |
158,000 |
0.20% |
|
|
| 38 |
BLACKROCK ADVISORS LLC |
106,993 |
156,000 |
0.20% |
|
|
| 39 |
Virtu KCG Holdings LLC |
105,826 |
155,000 |
0.19% |
|
|
| 40 |
METROPOLITAN LIFE INSURANCE CO/NY |
104,186 |
152,000 |
0.19% |
|
|
| 41 |
VOYA INVESTMENT MANAGEMENT LLC |
101,260 |
148,000 |
0.19% |
|
|
| 42 |
CREDIT SUISSE AG/ |
98,171 |
143,000 |
0.18% |
|
|
| 43 |
AMERICAN INTERNATIONAL GROUP, INC. |
97,031 |
142,000 |
0.18% |
|
|
| 44 |
PANAGORA ASSET MANAGEMENT INC |
95,833 |
139,000 |
0.17% |
|
|
| 45 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
94,200 |
138,000 |
0.17% |
|
|
| 46 |
AQR CAPITAL MANAGEMENT LLC |
80,700 |
118,000 |
0.15% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
78,455 |
115,000 |
0.14% |
|
|
| 48 |
First Heartland Consultants, Inc. |
74,624 |
109,000 |
0.14% |
|
|
| 49 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
73,500 |
107,000 |
0.13% |
|
|
| 50 |
MORGAN STANLEY |
59,806 |
88,000 |
0.11% |
|
|
