| 1 |
BVF INC/IL |
44,796,940 |
18,053,000 |
61.01% |
|
|
| 2 |
VANGUARD GROUP INC |
7,591,552 |
3,060,000 |
10.34% |
|
|
| 3 |
UNITED CAPITAL FINANCIAL ADVISORS, LLC |
526,210 |
2,157,000 |
7.29% |
|
|
| 4 |
BlackRock Institutional Trust Company, N.A. |
3,459,402 |
1,410,000 |
4.76% |
|
|
| 5 |
STONEPINE CAPITAL MANAGEMENT, LLC |
2,617,136 |
1,067,000 |
3.61% |
|
|
| 6 |
RENAISSANCE TECHNOLOGIES LLC |
1,740,491 |
709,000 |
2.40% |
|
|
| 7 |
GEODE CAPITAL MANAGEMENT, LLC |
1,169,997 |
472,000 |
1.60% |
|
|
| 8 |
GOLDMAN SACHS GROUP INC |
1,137,955 |
464,000 |
1.57% |
|
|
| 9 |
FMR LLC |
952,369 |
384,000 |
1.30% |
|
|
| 10 |
BLAIR WILLIAM & CO/IL |
511,984 |
209,000 |
0.71% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
450,504 |
184,000 |
0.62% |
|
|
| 12 |
NORTHERN TRUST CORP |
373,181 |
153,000 |
0.52% |
|
|
| 13 |
COMMERZBANK AKTIENGESELLSCHAFT /FI |
356,903 |
145,000 |
0.49% |
|
|
| 14 |
TIEDEMANN ADVISORS, LLC |
334,310 |
136,000 |
0.46% |
|
|
| 15 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
322,389 |
131,000 |
0.44% |
|
|
| 16 |
WASHINGTON TRUST Co |
314,000 |
128,000 |
0.43% |
|
|
| 17 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
297,000 |
120,000 |
0.41% |
|
|
| 18 |
Bank of New York Mellon Corp |
216,429 |
88,000 |
0.30% |
|
|
| 19 |
Caprock Group, LLC |
150,000 |
61,000 |
0.21% |
|
|
| 20 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
118,181 |
48,000 |
0.16% |
|
|
| 21 |
Virtu KCG Holdings LLC |
108,011 |
44,000 |
0.15% |
|
|
| 22 |
UBS Group AG |
86,841 |
35,000 |
0.12% |
|
|
| 23 |
AQR CAPITAL MANAGEMENT LLC |
80,700 |
33,000 |
0.11% |
|
|
| 24 |
JANE STREET GROUP, LLC |
76,772 |
31,000 |
0.10% |
|
|
| 25 |
CITADEL ADVISORS LLC |
66,956 |
27,000 |
0.09% |
|
|
| 26 |
GUGGENHEIM CAPITAL LLC |
63,017 |
25,000 |
0.08% |
|
|
| 27 |
TWO SIGMA SECURITIES, LLC |
60,419 |
24,000 |
0.08% |
|
|
| 28 |
Squarepoint Ops LLC |
56,900 |
23,000 |
0.08% |
|
|
| 29 |
BlackRock Fund Advisors |
52,768 |
22,000 |
0.07% |
|
|
| 30 |
JW Asset Management, LLC |
50,254 |
21,000 |
0.07% |
|
|
| 31 |
MORGAN STANLEY |
45,614 |
18,000 |
0.06% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
42,651 |
17,000 |
0.06% |
|
|
| 33 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
39,200 |
16,000 |
0.05% |
Call |
|
| 34 |
FIRST NEW YORK SECURITIES LLC /NY |
35,000 |
14,266 |
0.05% |
|
|
| 35 |
BLACKROCK ADVISORS LLC |
26,414 |
11,000 |
0.04% |
|
|
| 36 |
D. E. Shaw & Co., Inc. |
23,260 |
9,000 |
0.03% |
|
|
| 37 |
Nine Chapters Capital Management LLC |
17,200 |
7,000 |
0.02% |
|
|
| 38 |
BOKF, NA |
15,000 |
6,000 |
0.02% |
|
|
| 39 |
Janney Montgomery Scott LLC |
13,700 |
6,000 |
0.02% |
|
|
| 40 |
Connor, Clark & Lunn Investment Management Ltd. |
11,500 |
5,000 |
0.02% |
|
|
| 41 |
PRELUDE CAPITAL MANAGEMENT, LLC |
13,000 |
5,000 |
0.02% |
|
|
| 42 |
JPMORGAN CHASE & CO |
6,997 |
3,000 |
0.01% |
|
|
| 43 |
Compagnie Lombard Odier SCmA |
8,000 |
3,000 |
0.01% |
|
|
| 44 |
CUTLER GROUP LLC / CA |
7,840 |
3,000 |
0.01% |
|
|
| 45 |
ADVISOR GROUP, INC. |
5,500 |
2,000 |
0.01% |
|
|
| 46 |
BARCLAYS PLC |
5,517 |
2,000 |
0.01% |
|
|
| 47 |
MassMutual Private Wealth & Trust, FSB |
200 |
82 |
0.00% |
|
|
| 48 |
MSI Financial Services Inc |
16 |
0 |
0.00% |
|
|
| 49 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
1,203 |
0 |
0.00% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
253 |
0 |
0.00% |
|
|
