| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 1,075,037 | 15,519,000 | 20.20% | ||
| 2 | FMR LLC | 575,000 | 8,706,000 | 11.33% | ||
| 3 | Tourbillon Capital Partners, L.P. | 480,000 | 7,267,000 | 9.46% | ||
| 4 | Redmile Group, LLC | 414,330 | 6,273,000 | 8.17% | ||
| 5 | FRANKLIN RESOURCES INC | 400,000 | 6,056,000 | 7.88% | ||
| 6 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 304,000 | 4,603,000 | 5.99% | ||
| 7 | Alyeska Investment Group, L.P. | 273,000 | 4,133,000 | 5.38% | ||
| 8 | AMERIPRISE FINANCIAL INC | 248,713 | 3,765,000 | 4.90% | ||
| 9 | SPHERA FUNDS MANAGEMENT LTD. | 230,000 | 3,482,000 | 4.53% | ||
| 10 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 205,000 | 3,102,000 | 4.04% | ||
| 11 | JPMORGAN CHASE & CO | 198,750 | 3,009,000 | 3.92% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 180,000 | 2,725,000 | 3.55% | ||
| 13 | JENNISON ASSOCIATES LLC | 157,130 | 2,379,000 | 3.10% | ||
| 14 | MORGAN STANLEY | 155,965 | 2,362,000 | 3.07% | ||
| 15 | PUTNAM INVESTMENTS LLC | 67,500 | 1,022,000 | 1.33% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 53,000 | 802,000 | 1.04% | ||
| 17 | DEUTSCHE BANK AG\ | 48,751 | 738,000 | 0.96% | ||
| 18 | DESTRIER CAPITAL MANAGEMENT LLC | 16,800 | 254,000 | 0.33% | ||
| 19 | Cubist Systematic Strategies, LLC | 16,659 | 252,000 | 0.33% | ||
| 20 | Spark Investment Management LLC | 10,300 | 155,000 | 0.20% | ||
| 21 | BANK OF MONTREAL /CAN/ | 8,000 | 121,000 | 0.16% | ||
| 22 | Creative Planning | 3,300 | 50,000 | 0.07% | ||
| 23 | UBS AG | 1,080 | 16,000 | 0.02% | ||
| 24 | Stevens First Principles Investment Advisors | 800 | 12,000 | 0.02% | ||
| 25 | CITIGROUP INC | 696 | 11,000 | 0.01% | ||
| 26 | Tower Research Capital LLC (TRC) | 188 | 3,000 | 0.00% | ||
| 27 | MANAGED ACCOUNT ADVISORS LLC | 203 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
