| 1 |
Novo Holdings A/S |
1,238,252 |
12,816,000 |
17.54% |
|
|
| 2 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
658,402 |
6,814,000 |
9.32% |
|
|
| 3 |
SABBY MANAGEMENT, LLC |
654,283 |
6,772,000 |
9.27% |
|
|
| 4 |
Bank of New York Mellon Corp |
645,464 |
6,680,000 |
9.14% |
|
|
| 5 |
FMR LLC |
575,000 |
5,951,000 |
8.14% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
485,338 |
5,024,000 |
6.87% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
451,700 |
4,675,000 |
6.40% |
|
|
| 8 |
ALPS ADVISORS INC |
35,082 |
3,631,000 |
4.97% |
|
|
| 9 |
Alyeska Investment Group, L.P. |
337,454 |
3,493,000 |
4.78% |
|
|
| 10 |
BlackRock Fund Advisors |
242,041 |
2,505,000 |
3.43% |
|
|
| 11 |
VANGUARD GROUP INC |
229,956 |
2,380,000 |
3.26% |
|
|
| 12 |
JPMORGAN CHASE & CO |
189,525 |
1,961,000 |
2.68% |
|
|
| 13 |
Green Owl Capital Management, LLC |
140,000 |
1,449,000 |
1.98% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
123,549 |
1,279,000 |
1.75% |
|
|
| 15 |
AMERIPRISE FINANCIAL INC |
109,865 |
1,137,000 |
1.56% |
|
|
| 16 |
NORTHERN TRUST CORP |
93,297 |
966,000 |
1.32% |
|
|
| 17 |
STATE STREET CORP |
71,497 |
739,000 |
1.01% |
|
|
| 18 |
PUTNAM INVESTMENTS LLC |
67,500 |
699,000 |
0.96% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
51,191 |
529,000 |
0.72% |
|
|
| 20 |
DEUTSCHE BANK AG\ |
37,659 |
389,000 |
0.53% |
|
|
| 21 |
NJ State Employees Deferred Compensation Plan |
35,000 |
362,000 |
0.50% |
|
|
| 22 |
BlackRock Investment Management, LLC |
34,683 |
359,000 |
0.49% |
|
|
| 23 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
34,017 |
352,000 |
0.48% |
|
|
| 24 |
SHEPHERD KAPLAN KROCHUK, LLC |
25,791 |
267,000 |
0.37% |
|
|
| 25 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
17,900 |
186,000 |
0.25% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
17,218 |
178,000 |
0.24% |
|
|
| 27 |
MILLENNIUM MANAGEMENT LLC |
14,744 |
153,000 |
0.21% |
|
|
| 28 |
TEACHERS ADVISORS, LLC |
13,864 |
143,000 |
0.20% |
|
|
| 29 |
OPPENHEIMER & CO INC |
13,548 |
141,000 |
0.19% |
|
|
| 30 |
GOLDMAN SACHS GROUP INC |
12,368 |
128,000 |
0.18% |
|
|
| 31 |
Virtu KCG Holdings LLC |
11,525 |
119,000 |
0.16% |
|
|
| 32 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
10,000 |
104,000 |
0.14% |
|
|
| 33 |
RHUMBLINE ADVISERS |
10,093 |
104,000 |
0.14% |
|
|
| 34 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,600 |
89,000 |
0.12% |
|
|
| 35 |
CITIGROUP INC |
6,852 |
71,000 |
0.10% |
|
|
| 36 |
BLACKROCK ADVISORS LLC |
6,223 |
64,000 |
0.09% |
|
|
| 37 |
Nationwide Fund Advisors |
6,088 |
63,000 |
0.09% |
|
|
| 38 |
ROPES WEALTH ADVISORS LLC |
6,000 |
62,000 |
0.08% |
|
|
| 39 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,563 |
58,000 |
0.08% |
|
|
| 40 |
MORGAN STANLEY |
4,402 |
45,000 |
0.06% |
|
|
| 41 |
Creative Planning |
3,300 |
34,000 |
0.05% |
|
|
| 42 |
BNP PARIBAS FINANCIAL MARKETS |
2,134 |
22,087 |
0.03% |
|
|
| 43 |
BANK OF AMERICA CORP /DE/ |
2,136 |
22,000 |
0.03% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,020 |
21,000 |
0.03% |
|
|
| 45 |
COLONY GROUP LLC |
2,000 |
21,000 |
0.03% |
|
|
| 46 |
UBS Group AG |
948 |
10,000 |
0.01% |
|
|
| 47 |
ROYAL BANK OF CANADA |
376 |
4,000 |
0.01% |
|
|
| 48 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
300 |
3,000 |
0.00% |
|
|
| 49 |
BlackRock Finance, Inc. |
213 |
2,000 |
0.00% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
51 |
1,000 |
0.00% |
|
|
