| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 1,178,992 | 17,378,000 | 19.05% | ||
| 2 | FMR LLC | 575,000 | 8,476,000 | 9.29% | ||
| 3 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 567,978 | 8,372,000 | 9.18% | ||
| 4 | Tourbillon Capital Partners, L.P. | 517,000 | 7,621,000 | 8.35% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 485,338 | 7,154,000 | 7.84% | ||
| 6 | FRANKLIN RESOURCES INC | 443,300 | 6,534,000 | 7.16% | ||
| 7 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 304,000 | 4,481,000 | 4.91% | ||
| 8 | Alyeska Investment Group, L.P. | 263,252 | 3,880,000 | 4.25% | ||
| 9 | Redmile Group, LLC | 215,139 | 3,171,000 | 3.48% | ||
| 10 | JPMORGAN CHASE & CO | 195,675 | 2,884,000 | 3.16% | ||
| 11 | AMERIPRISE FINANCIAL INC | 178,895 | 2,637,000 | 2.89% | ||
| 12 | BlackRock Fund Advisors | 162,413 | 2,394,000 | 2.62% | ||
| 13 | VANGUARD GROUP INC | 158,356 | 2,334,000 | 2.56% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 153,841 | 2,268,000 | 2.49% | ||
| 15 | AWM Investment Company, Inc. | 100,000 | 1,474,000 | 1.62% | ||
| 16 | DEUTSCHE BANK AG\ | 93,954 | 1,384,000 | 1.52% | ||
| 17 | Green Owl Capital Management, LLC | 86,000 | 1,268,000 | 1.39% | ||
| 18 | PUTNAM INVESTMENTS LLC | 67,500 | 995,000 | 1.09% | ||
| 19 | DSC Advisors, L.P. | 67,504 | 995,000 | 1.09% | ||
| 20 | NORTHERN TRUST CORP | 56,016 | 825,000 | 0.90% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 43,240 | 637,000 | 0.70% | ||
| 22 | BLAIR WILLIAM & CO/IL | 38,000 | 560,000 | 0.61% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 37,585 | 554,000 | 0.61% | ||
| 24 | GOLDMAN SACHS GROUP INC | 35,935 | 530,000 | 0.58% | ||
| 25 | STATE STREET CORP | 28,329 | 417,000 | 0.46% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,797 | 351,000 | 0.38% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 21,101 | 311,000 | 0.34% | ||
| 28 | DESTRIER CAPITAL MANAGEMENT LLC | 16,800 | 248,000 | 0.27% | ||
| 29 | BlackRock Investment Management, LLC | 15,828 | 233,000 | 0.26% | ||
| 30 | Bank of New York Mellon Corp | 14,952 | 220,000 | 0.24% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,000 | 162,000 | 0.18% | ||
| 32 | BANK OF MONTREAL /CAN/ | 8,000 | 118,000 | 0.13% | ||
| 33 | TEACHERS ADVISORS, LLC | 6,036 | 89,000 | 0.10% | ||
| 34 | Nationwide Fund Advisors | 4,014 | 59,000 | 0.06% | ||
| 35 | AMERICAN INTERNATIONAL GROUP, INC. | 3,719 | 54,818 | 0.06% | ||
| 36 | Creative Planning | 3,300 | 49,000 | 0.05% | ||
| 37 | STRS OHIO | 2,000 | 29,000 | 0.03% | ||
| 38 | BLACKROCK ADVISORS LLC | 1,992 | 29,000 | 0.03% | ||
| 39 | UBS Group AG | 1,164 | 17,000 | 0.02% | ||
| 40 | Stevens First Principles Investment Advisors | 1,100 | 16,000 | 0.02% | ||
| 41 | CITIGROUP INC | 1,014 | 15,000 | 0.02% | ||
| 42 | BARCLAYS PLC | 480 | 7,000 | 0.01% | ||
| 43 | MORGAN STANLEY | 295 | 4,000 | 0.00% | ||
| 44 | MANAGED ACCOUNT ADVISORS LLC | 237 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
