| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 1,184,196 | 13,381,000 | 19.13% | ||
| 2 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 677,978 | 7,661,000 | 10.95% | ||
| 3 | FMR LLC | 575,000 | 6,498,000 | 9.29% | ||
| 4 | Tourbillon Capital Partners, L.P. | 517,000 | 5,842,000 | 8.35% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 458,338 | 5,484,000 | 7.84% | ||
| 6 | FRANKLIN RESOURCES INC | 451,700 | 5,104,000 | 7.30% | ||
| 7 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 304,000 | 3,435,000 | 4.91% | ||
| 8 | Alyeska Investment Group, L.P. | 284,142 | 3,211,000 | 4.59% | ||
| 9 | VANGUARD GROUP INC | 191,673 | 2,166,000 | 3.10% | ||
| 10 | JPMORGAN CHASE & CO | 190,850 | 2,156,000 | 3.08% | ||
| 11 | BlackRock Fund Advisors | 170,525 | 1,927,000 | 2.75% | ||
| 12 | AMERIPRISE FINANCIAL INC | 168,588 | 1,905,000 | 2.72% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 146,341 | 1,654,000 | 2.36% | ||
| 14 | Green Owl Capital Management, LLC | 110,000 | 1,243,000 | 1.78% | ||
| 15 | ASCEND CAPITAL, LLC | 100,000 | 1,130,000 | 1.62% | ||
| 16 | Sio Capital Management, LLC | 82,283 | 930,000 | 1.33% | ||
| 17 | DSC Advisors, L.P. | 70,000 | 791,000 | 1.13% | ||
| 18 | PUTNAM INVESTMENTS LLC | 67,500 | 763,000 | 1.09% | ||
| 19 | NORTHERN TRUST CORP | 64,166 | 725,000 | 1.04% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 47,059 | 532,000 | 0.76% | ||
| 21 | STATE STREET CORP | 45,349 | 512,000 | 0.73% | ||
| 22 | DEUTSCHE BANK AG\ | 45,201 | 510,000 | 0.73% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 40,088 | 452,000 | 0.65% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 21,101 | 238,000 | 0.34% | ||
| 25 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 20,156 | 228,000 | 0.33% | ||
| 26 | BLAIR WILLIAM & CO/IL | 18,300 | 206,000 | 0.29% | ||
| 27 | BlackRock Investment Management, LLC | 17,778 | 201,000 | 0.29% | ||
| 28 | Bank of New York Mellon Corp | 16,760 | 190,000 | 0.27% | ||
| 29 | GOLDMAN SACHS GROUP INC | 14,935 | 169,000 | 0.24% | ||
| 30 | A.R.T. Advisors, LLC | 13,842 | 156,000 | 0.22% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,000 | 124,000 | 0.18% | ||
| 32 | TEACHERS ADVISORS, LLC | 6,036 | 68,000 | 0.10% | ||
| 33 | CITIGROUP INC | 5,905 | 67,000 | 0.10% | ||
| 34 | Nationwide Fund Advisors | 4,423 | 50,000 | 0.07% | ||
| 35 | MORGAN STANLEY | 3,923 | 44,000 | 0.06% | ||
| 36 | AMERICAN INTERNATIONAL GROUP, INC. | 3,719 | 42,025 | 0.06% | ||
| 37 | Creative Planning | 3,300 | 37,000 | 0.05% | ||
| 38 | BLACKROCK ADVISORS LLC | 2,795 | 32,000 | 0.05% | ||
| 39 | Tower Research Capital LLC (TRC) | 2,385 | 27,000 | 0.04% | ||
| 40 | STRS OHIO | 1,900 | 21,000 | 0.03% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 1,400 | 16,000 | 0.02% | ||
| 42 | Stevens First Principles Investment Advisors | 1,100 | 12,000 | 0.02% | ||
| 43 | WELLS FARGO & COMPANY/MN | 1,023 | 11,000 | 0.02% | ||
| 44 | BARCLAYS PLC | 182 | 2,000 | 0.00% | ||
| 45 | MANAGED ACCOUNT ADVISORS LLC | 176 | 2,000 | 0.00% | ||
| 46 | BlackRock Finance, Inc. | 213 | 2,000 | 0.00% | ||
| 47 | UBS Group AG | 150 | 2,000 | 0.00% | ||
| 48 | BNP PARIBAS FINANCIAL MARKETS | 143 | 1,616 | 0.00% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 76 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
