| 1 |
Novo Holdings A/S |
1,238,252 |
16,469,000 |
20.03% |
|
|
| 2 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
740,978 |
9,855,000 |
11.99% |
|
|
| 3 |
FMR LLC |
575,000 |
7,648,000 |
9.30% |
|
|
| 4 |
Tourbillon Capital Partners, L.P. |
517,000 |
6,876,000 |
8.36% |
|
|
| 5 |
PERCEPTIVE ADVISORS LLC |
485,338 |
6,455,000 |
7.85% |
|
|
| 6 |
FRANKLIN RESOURCES INC |
451,700 |
6,008,000 |
7.31% |
|
|
| 7 |
Alyeska Investment Group, L.P. |
306,567 |
4,077,000 |
4.96% |
|
|
| 8 |
Bank of New York Mellon Corp |
261,672 |
3,480,000 |
4.23% |
|
|
| 9 |
BlackRock Fund Advisors |
243,693 |
3,241,000 |
3.94% |
|
|
| 10 |
VANGUARD GROUP INC |
201,712 |
2,683,000 |
3.26% |
|
|
| 11 |
JPMORGAN CHASE & CO |
174,475 |
2,320,000 |
2.82% |
|
|
| 12 |
AMERIPRISE FINANCIAL INC |
137,075 |
1,823,000 |
2.22% |
|
|
| 13 |
Green Owl Capital Management, LLC |
130,000 |
1,729,000 |
2.10% |
|
|
| 14 |
SABBY MANAGEMENT, LLC |
128,041 |
1,703,000 |
2.07% |
|
|
| 15 |
PUTNAM INVESTMENTS LLC |
67,500 |
898,000 |
1.09% |
|
|
| 16 |
NORTHERN TRUST CORP |
65,479 |
871,000 |
1.06% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
62,021 |
825,000 |
1.00% |
|
|
| 18 |
STATE STREET CORP |
56,303 |
751,000 |
0.91% |
|
|
| 19 |
DEUTSCHE BANK AG\ |
48,156 |
639,000 |
0.78% |
|
|
| 20 |
ALLIANCEBERNSTEIN L.P. |
46,090 |
613,000 |
0.75% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
42,995 |
571,000 |
0.69% |
|
|
| 22 |
BlackRock Investment Management, LLC |
34,988 |
465,000 |
0.57% |
|
|
| 23 |
ALPS ADVISORS INC |
22,261 |
296,000 |
0.36% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,437 |
259,000 |
0.32% |
|
|
| 25 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
17,318 |
230,000 |
0.28% |
|
|
| 26 |
DISCOVERY CAPITAL MANAGEMENT, LLC / CT |
15,294 |
203,000 |
0.25% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
13,864 |
184,000 |
0.22% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
12,193 |
162,000 |
0.20% |
|
|
| 29 |
OPPENHEIMER & CO INC |
12,048 |
160,000 |
0.19% |
|
|
| 30 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
10,000 |
133,000 |
0.16% |
|
|
| 31 |
NEW YORK STATE COMMON RETIREMENT FUND |
8,600 |
114,000 |
0.14% |
|
|
| 32 |
Nationwide Fund Advisors |
6,088 |
81,000 |
0.10% |
|
|
| 33 |
ROPES WEALTH ADVISORS LLC |
6,000 |
80,000 |
0.10% |
|
|
| 34 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,557 |
73,908 |
0.09% |
|
|
| 35 |
BLACKROCK ADVISORS LLC |
5,512 |
73,000 |
0.09% |
|
|
| 36 |
CITIGROUP INC |
5,051 |
67,000 |
0.08% |
|
|
| 37 |
STRS OHIO |
3,000 |
39,000 |
0.05% |
|
|
| 38 |
BNP PARIBAS FINANCIAL MARKETS |
789 |
10,494 |
0.01% |
|
|
| 39 |
ROYAL BANK OF CANADA |
765 |
10,000 |
0.01% |
|
|
| 40 |
Tower Research Capital LLC (TRC) |
499 |
7,000 |
0.01% |
|
|
| 41 |
WELLS FARGO & COMPANY/MN |
475 |
6,000 |
0.01% |
|
|
| 42 |
MORGAN STANLEY |
434 |
6,000 |
0.01% |
|
|
| 43 |
Jefferies Group LLC |
357 |
5,000 |
0.01% |
|
|
| 44 |
Invesco Ltd. |
397 |
5,000 |
0.01% |
|
|
| 45 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
300 |
4,000 |
0.00% |
|
|
| 46 |
MANAGED ACCOUNT ADVISORS LLC |
188 |
3,000 |
0.00% |
|
|
| 47 |
BlackRock Finance, Inc. |
213 |
3,000 |
0.00% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
128 |
2,000 |
0.00% |
|
|
| 49 |
BARCLAYS PLC |
182 |
2,000 |
0.00% |
|
|
| 50 |
UBS Group AG |
150 |
2,000 |
0.00% |
|
|
