| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 5,359,632 | 75,035,000 | 20.69% | ||
| 2 | Redmile Group, LLC | 2,734,044 | 38,277,000 | 10.56% | ||
| 3 | ArrowMark Colorado Holdings LLC | 2,083,017 | 29,162,000 | 8.04% | ||
| 4 | BlackRock Finance, Inc. | 1,923,515 | 26,929,000 | 7.43% | ||
| 5 | FMR LLC | 1,906,368 | 26,689,000 | 7.36% | ||
| 6 | BRIDGER MANAGEMENT, LLC | 1,524,191 | 21,339,000 | 5.88% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,492,976 | 20,901,000 | 5.76% | ||
| 8 | RTW INVESTMENTS, LP | 1,172,744 | 16,418,000 | 4.53% | ||
| 9 | MORGAN STANLEY | 986,547 | 13,812,000 | 3.81% | ||
| 10 | Neuberger Berman Group LLC | 967,980 | 13,552,000 | 3.74% | ||
| 11 | VANGUARD GROUP INC | 845,877 | 11,842,000 | 3.27% | ||
| 12 | Camber Capital Management LP | 535,500 | 7,497,000 | 2.07% | ||
| 13 | Artal Group S.A. | 500,000 | 7,000,000 | 1.93% | ||
| 14 | STATE STREET CORP | 423,943 | 5,936,000 | 1.64% | ||
| 15 | NORGES BANK | 399,155 | 5,588,000 | 1.54% | ||
| 16 | 12 West Capital Management LP | 398,700 | 5,582,000 | 1.54% | ||
| 17 | Ghost Tree Capital, LLC | 350,000 | 4,900,000 | 1.35% | ||
| 18 | NORTHERN TRUST CORP | 298,739 | 4,183,000 | 1.15% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 188,425 | 2,637,000 | 0.73% | ||
| 20 | Alyeska Investment Group, L.P. | 171,745 | 2,404,000 | 0.66% | ||
| 21 | Bank of New York Mellon Corp | 125,713 | 1,760,000 | 0.49% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 125,624 | 1,759,000 | 0.49% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 92,974 | 1,302,000 | 0.36% | ||
| 24 | Vident Investment Advisory, LLC | 90,598 | 1,268,000 | 0.35% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 67,892 | 950,000 | 0.26% | ||
| 26 | BANK OF MONTREAL /CAN/ | 59,591 | 834,000 | 0.23% | ||
| 27 | WELLS FARGO & COMPANY/MN | 56,864 | 796,000 | 0.22% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,400 | 790,000 | 0.22% | Call | |
| 29 | TEACHERS ADVISORS, LLC | 47,156 | 660,000 | 0.18% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,104 | 631,000 | 0.17% | ||
| 31 | Alberta Investment Management Corp | 39,330 | 551,000 | 0.15% | ||
| 32 | CITADEL ADVISORS LLC | 36,462 | 510,000 | 0.14% | ||
| 33 | BARCLAYS PLC | 35,000 | 490,000 | 0.14% | Put | |
| 34 | BARCLAYS PLC | 35,000 | 490,000 | 0.14% | Call | |
| 35 | TIVERTON ASSET MANAGEMENT LLC | 31,624 | 443,000 | 0.12% | ||
| 36 | RHUMBLINE ADVISERS | 31,373 | 439,000 | 0.12% | ||
| 37 | MARSHALL WACE NORTH AMERICA, L.P. | 30,359 | 425,000 | 0.12% | ||
| 38 | SECOR Capital Advisors, LP | 30,287 | 424,000 | 0.12% | ||
| 39 | DEUTSCHE BANK AG\ | 30,383 | 424,000 | 0.12% | ||
| 40 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 29,673 | 415,000 | 0.11% | ||
| 41 | Swiss National Bank | 28,600 | 400,000 | 0.11% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 27,740 | 388,000 | 0.11% | ||
| 43 | ALPS ADVISORS INC | 26,274 | 368,000 | 0.10% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 24,700 | 346,000 | 0.10% | ||
| 45 | RAYMOND JAMES & ASSOCIATES | 23,594 | 330,000 | 0.09% | ||
| 46 | IndexIQ Advisors LLC | 23,041 | 323,000 | 0.09% | ||
| 47 | Old West Investment Management, LLC | 22,700 | 317,000 | 0.09% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,200 | 311,000 | 0.09% | Put | |
| 49 | DIMENSIONAL FUND ADVISORS LP | 21,718 | 304,000 | 0.08% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,377 | 285,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
