| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,527,386 | 59,394,000 | 10.32% | ||
| 2 | VANGUARD GROUP INC | 2,467,714 | 57,992,000 | 10.07% | ||
| 3 | WADDELL & REED FINANCIAL INC | 2,030,012 | 47,705,000 | 8.29% | ||
| 4 | FRANKLIN RESOURCES INC | 1,742,176 | 40,941,000 | 7.11% | ||
| 5 | JPMORGAN CHASE & CO | 1,603,332 | 37,679,000 | 6.55% | ||
| 6 | Visium Asset Management, LP | 1,570,141 | 36,898,000 | 6.41% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 1,390,366 | 32,674,000 | 5.68% | ||
| 8 | EcoR1 Capital, LLC | 1,205,391 | 28,327,000 | 4.92% | ||
| 9 | BlackRock Fund Advisors | 1,140,004 | 26,790,000 | 4.65% | ||
| 10 | Omega Fund Management, LLC | 972,175 | 22,846,000 | 3.97% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 934,036 | 21,950,000 | 3.81% | ||
| 12 | STATE STREET CORP | 640,900 | 15,061,000 | 2.62% | ||
| 13 | FMR LLC | 551,603 | 12,963,000 | 2.25% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 477,973 | 11,232,000 | 1.95% | ||
| 15 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 455,997 | 10,715,000 | 1.86% | ||
| 16 | Opaleye Management Inc. | 325,000 | 7,638,000 | 1.33% | ||
| 17 | HAMILTON LANE ADVISORS LLC | 256,839 | 6,036,000 | 1.05% | ||
| 18 | TIAA CREF INVESTMENT MANAGEMENT LLC | 239,481 | 5,628,000 | 0.98% | ||
| 19 | Rock Springs Capital Management LP | 190,000 | 4,465,000 | 0.78% | ||
| 20 | LAZARD ASSET MANAGEMENT LLC | 179,290 | 4,213,000 | 0.73% | ||
| 21 | Asset Management One Co., Ltd. | 175,534 | 4,046,000 | 0.70% | ||
| 22 | GOLDMAN SACHS GROUP INC | 169,238 | 3,977,000 | 0.69% | ||
| 23 | Bank of New York Mellon Corp | 163,785 | 3,849,000 | 0.67% | ||
| 24 | D. E. Shaw & Co., Inc. | 163,224 | 3,836,000 | 0.67% | ||
| 25 | BlackRock Investment Management, LLC | 161,680 | 3,799,000 | 0.66% | ||
| 26 | CITIGROUP INC | 144,238 | 3,389,000 | 0.59% | ||
| 27 | BLACKROCK ADVISORS LLC | 133,871 | 3,146,000 | 0.55% | ||
| 28 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 133,383 | 3,135,000 | 0.54% | ||
| 29 | NORTHERN TRUST CORP | 123,948 | 2,912,000 | 0.51% | ||
| 30 | CREDIT SUISSE AG/ | 119,034 | 2,797,000 | 0.49% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 111,308 | 2,615,000 | 0.45% | ||
| 32 | SABBY MANAGEMENT, LLC | 98,100 | 2,305,000 | 0.40% | ||
| 33 | MORGAN STANLEY | 96,979 | 2,279,000 | 0.40% | ||
| 34 | LMCG INVESTMENTS, LLC | 95,881 | 2,253,000 | 0.39% | ||
| 35 | BBT Capital Management, LLC | 87,911 | 2,066,000 | 0.36% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 87,401 | 2,054,000 | 0.36% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 77,037 | 1,811,000 | 0.31% | ||
| 38 | PRINCIPAL FINANCIAL GROUP INC | 76,914 | 1,808,000 | 0.31% | ||
| 39 | Overbrook Management Corp | 73,820 | 1,735,000 | 0.30% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 73,700 | 1,732,000 | 0.30% | ||
| 41 | TEACHERS ADVISORS, LLC | 69,631 | 1,636,000 | 0.28% | ||
| 42 | PALISADE CAPITAL MANAGEMENT, LP | 65,000 | 1,527,000 | 0.27% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,900 | 1,525,000 | 0.26% | Call | |
| 44 | ALPS ADVISORS INC | 58,847 | 1,383,000 | 0.24% | ||
| 45 | DEUTSCHE BANK AG\ | 57,199 | 1,343,000 | 0.23% | ||
| 46 | Cubist Systematic Strategies, LLC | 56,360 | 1,324,000 | 0.23% | ||
| 47 | Hilltop Holdings Inc. | 48,975 | 1,151,000 | 0.20% | ||
| 48 | Private Wealth Partners, LLC | 46,300 | 1,088,000 | 0.19% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,200 | 1,086,000 | 0.19% | Put | |
| 50 | Invesco Ltd. | 44,849 | 1,054,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
