| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 4,220,201 | 69,254,000 | 13.66% | ||
| 2 | BlackRock Fund Advisors | 2,053,134 | 33,692,000 | 6.65% | ||
| 3 | WADDELL & REED FINANCIAL INC | 2,031,512 | 33,337,000 | 6.58% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,710,000 | 28,061,000 | 5.53% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 1,639,985 | 26,911,000 | 5.31% | ||
| 6 | STATE STREET CORP | 1,329,055 | 21,806,000 | 4.30% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,286,883 | 21,118,000 | 4.17% | ||
| 8 | JPMORGAN CHASE & CO | 1,282,804 | 21,051,000 | 4.15% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 925,727 | 15,191,000 | 3.00% | ||
| 10 | FMR LLC | 886,503 | 14,548,000 | 2.87% | ||
| 11 | Omega Fund Management, LLC | 822,175 | 13,492,000 | 2.66% | ||
| 12 | GOLDMAN SACHS GROUP INC | 820,692 | 13,467,000 | 2.66% | ||
| 13 | EcoR1 Capital, LLC | 788,745 | 12,943,000 | 2.55% | ||
| 14 | NORTHERN TRUST CORP | 595,748 | 9,777,000 | 1.93% | ||
| 15 | TEACHERS ADVISORS, LLC | 441,567 | 7,246,000 | 1.43% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 422,305 | 6,929,000 | 1.37% | ||
| 17 | CREDIT SUISSE AG/ | 420,167 | 6,896,000 | 1.36% | ||
| 18 | OppenheimerFunds, Inc. | 353,200 | 5,796,000 | 1.14% | ||
| 19 | PointState Capital LP | 350,000 | 5,744,000 | 1.13% | ||
| 20 | Opaleye Management Inc. | 330,000 | 5,415,000 | 1.07% | ||
| 21 | NORGES BANK | 322,326 | 5,289,000 | 1.04% | ||
| 22 | Candriam S.C.A. | 271,000 | 4,447,000 | 0.88% | ||
| 23 | Invesco Ltd. | 258,834 | 4,247,000 | 0.84% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 250,341 | 4,108,000 | 0.81% | ||
| 25 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 241,468 | 3,962,000 | 0.78% | ||
| 26 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 237,326 | 3,895,000 | 0.77% | ||
| 27 | AMERICAN CENTURY COMPANIES INC | 230,019 | 3,775,000 | 0.74% | ||
| 28 | Bank of New York Mellon Corp | 226,218 | 3,712,000 | 0.73% | ||
| 29 | BANK OF AMERICA CORP /DE/ | 226,147 | 3,711,000 | 0.73% | ||
| 30 | Rock Springs Capital Management LP | 225,000 | 3,692,000 | 0.73% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 218,395 | 3,584,000 | 0.71% | ||
| 32 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 214,356 | 3,518,000 | 0.69% | ||
| 33 | DEUTSCHE BANK AG\ | 201,576 | 3,307,000 | 0.65% | ||
| 34 | BlackRock Investment Management, LLC | 194,920 | 3,199,000 | 0.63% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 183,822 | 3,017,000 | 0.60% | ||
| 36 | OXFORD ASSET MANAGEMENT LLP | 170,987 | 2,806,000 | 0.55% | ||
| 37 | Asset Management One Co., Ltd. | 168,735 | 2,767,000 | 0.55% | ||
| 38 | JACOBS LEVY EQUITY MANAGEMENT, INC | 167,761 | 2,753,000 | 0.54% | ||
| 39 | WELLINGTON MANAGEMENT GROUP LLP | 157,444 | 2,583,000 | 0.51% | ||
| 40 | NEXTHERA CAPITAL LP | 154,000 | 2,527,000 | 0.50% | ||
| 41 | BLACKROCK ADVISORS LLC | 135,402 | 2,222,000 | 0.44% | ||
| 42 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 126,174 | 2,071,000 | 0.41% | ||
| 43 | CITADEL ADVISORS LLC | 117,961 | 1,936,000 | 0.38% | ||
| 44 | A.R.T. Advisors, LLC | 117,163 | 1,922,000 | 0.38% | ||
| 45 | HBK INVESTMENTS L P | 115,661 | 1,898,000 | 0.37% | ||
| 46 | Rhenman & Partners Asset Management AB | 114,000 | 1,871,000 | 0.37% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 113,170 | 1,857,000 | 0.37% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 109,808 | 1,802,000 | 0.36% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 101,900 | 1,672,000 | 0.33% | ||
| 50 | SECOR Capital Advisors, LP | 101,050 | 1,658,000 | 0.33% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
