| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 3,586,867 | 109,292,000 | 11.58% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,060,000 | 62,768,000 | 6.65% | ||
| 3 | Visium Asset Management, LP | 2,031,936 | 61,913,000 | 6.56% | ||
| 4 | WADDELL & REED FINANCIAL INC | 2,031,512 | 61,900,000 | 6.56% | ||
| 5 | BlackRock Fund Advisors | 1,904,333 | 58,025,000 | 6.15% | ||
| 6 | JPMORGAN CHASE & CO | 1,753,815 | 53,438,000 | 5.66% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 1,729,635 | 52,702,000 | 5.58% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,240,723 | 37,805,000 | 4.00% | ||
| 9 | EcoR1 Capital, LLC | 1,216,473 | 37,066,000 | 3.93% | ||
| 10 | STATE STREET CORP | 1,156,440 | 35,235,000 | 3.73% | ||
| 11 | FMR LLC | 1,044,503 | 31,826,000 | 3.37% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 929,067 | 28,309,000 | 3.00% | ||
| 13 | Omega Fund Management, LLC | 822,175 | 25,052,000 | 2.65% | ||
| 14 | FRANKLIN RESOURCES INC | 576,608 | 17,569,000 | 1.86% | ||
| 15 | NORTHERN TRUST CORP | 528,153 | 16,093,000 | 1.70% | ||
| 16 | BANK OF AMERICA CORP /DE/ | 422,884 | 12,885,000 | 1.36% | ||
| 17 | HIGHLAND CAPITAL MANAGEMENT LP | 413,914 | 12,612,000 | 1.34% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 377,506 | 11,502,000 | 1.22% | ||
| 19 | TEACHERS ADVISORS, LLC | 374,898 | 11,423,000 | 1.21% | ||
| 20 | GOLDMAN SACHS GROUP INC | 373,008 | 11,366,000 | 1.20% | ||
| 21 | Opaleye Management Inc. | 325,000 | 9,903,000 | 1.05% | ||
| 22 | NORGES BANK | 322,326 | 9,821,000 | 1.04% | ||
| 23 | Candriam S.C.A. | 260,000 | 7,922,000 | 0.84% | ||
| 24 | Bank of New York Mellon Corp | 257,155 | 7,836,000 | 0.83% | ||
| 25 | D. E. Shaw & Co., Inc. | 245,408 | 7,478,000 | 0.79% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 232,582 | 7,087,000 | 0.75% | ||
| 27 | ROYAL BANK OF CANADA | 220,706 | 6,724,000 | 0.71% | ||
| 28 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 205,480 | 6,260,000 | 0.66% | ||
| 29 | Rock Springs Capital Management LP | 190,000 | 5,789,000 | 0.61% | ||
| 30 | Asset Management One Co., Ltd. | 174,902 | 5,484,000 | 0.58% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 168,864 | 5,146,000 | 0.55% | ||
| 32 | BlackRock Investment Management, LLC | 160,559 | 4,892,000 | 0.52% | ||
| 33 | CREDIT SUISSE AG/ | 156,862 | 4,779,000 | 0.51% | ||
| 34 | COLUMBUS CIRCLE INVESTORS | 142,164 | 4,332,000 | 0.46% | ||
| 35 | Informed Momentum Co LLC | 131,564 | 4,009,000 | 0.42% | ||
| 36 | OXFORD ASSET MANAGEMENT LLP | 121,526 | 3,770,000 | 0.40% | ||
| 37 | DEUTSCHE BANK AG\ | 123,051 | 3,748,000 | 0.40% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 111,500 | 3,397,000 | 0.36% | ||
| 39 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 110,862 | 3,378,000 | 0.36% | ||
| 40 | PRINCIPAL FINANCIAL GROUP INC | 108,747 | 3,314,000 | 0.35% | ||
| 41 | MORGAN STANLEY | 108,653 | 3,311,000 | 0.35% | ||
| 42 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 100,668 | 3,067,000 | 0.32% | ||
| 43 | VERTEX ONE ASSET MANAGEMENT INC. | 100,000 | 3,047,000 | 0.32% | ||
| 44 | BLACKROCK ADVISORS LLC | 94,948 | 2,893,000 | 0.31% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 90,717 | 2,764,000 | 0.29% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 88,701 | 2,703,000 | 0.29% | ||
| 47 | BBT Capital Management, LLC | 87,911 | 2,679,000 | 0.28% | ||
| 48 | ALPS ADVISORS INC | 80,800 | 2,462,000 | 0.26% | ||
| 49 | HANDELSBANKEN FONDER AB | 80,000 | 2,438,000 | 0.26% | ||
| 50 | AMERIPRISE FINANCIAL INC | 78,787 | 2,401,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
