| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 3,425,126 | 75,079,000 | 11.86% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,343,708 | 51,374,000 | 8.12% | ||
| 3 | WADDELL & REED FINANCIAL INC | 2,031,512 | 44,531,000 | 7.04% | ||
| 4 | Visium Asset Management, LP | 2,011,100 | 44,083,000 | 6.97% | ||
| 5 | JPMORGAN CHASE & CO | 1,606,351 | 35,211,000 | 5.56% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 1,495,471 | 32,781,000 | 5.18% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,262,641 | 27,677,000 | 4.37% | ||
| 8 | EcoR1 Capital, LLC | 1,230,391 | 26,970,000 | 4.26% | ||
| 9 | BlackRock Fund Advisors | 1,146,555 | 25,132,000 | 3.97% | ||
| 10 | FMR LLC | 935,503 | 20,506,000 | 3.24% | ||
| 11 | ALPS ADVISORS INC | 92,769 | 20,335,000 | 3.21% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 923,837 | 20,251,000 | 3.20% | ||
| 13 | Omega Fund Management, LLC | 872,175 | 19,118,000 | 3.02% | ||
| 14 | FRANKLIN RESOURCES INC | 851,308 | 18,661,000 | 2.95% | ||
| 15 | STATE STREET CORP | 741,809 | 16,258,000 | 2.57% | ||
| 16 | NORTHERN TRUST CORP | 511,957 | 11,222,000 | 1.77% | ||
| 17 | TEACHERS ADVISORS, LLC | 366,323 | 8,030,000 | 1.27% | ||
| 18 | GOLDMAN SACHS GROUP INC | 365,198 | 8,005,000 | 1.26% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 337,848 | 7,405,000 | 1.17% | ||
| 20 | Opaleye Management Inc. | 325,000 | 7,124,000 | 1.13% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 283,597 | 6,216,000 | 0.98% | ||
| 22 | Bank of New York Mellon Corp | 244,174 | 5,352,000 | 0.85% | ||
| 23 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 234,163 | 5,132,000 | 0.81% | ||
| 24 | Candriam S.C.A. | 200,700 | 4,400,000 | 0.70% | ||
| 25 | D. E. Shaw & Co., Inc. | 192,534 | 4,220,000 | 0.67% | ||
| 26 | Rock Springs Capital Management LP | 190,000 | 4,165,000 | 0.66% | ||
| 27 | LMCG INVESTMENTS, LLC | 181,195 | 3,972,000 | 0.63% | ||
| 28 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 160,276 | 3,513,000 | 0.56% | ||
| 29 | BlackRock Investment Management, LLC | 159,988 | 3,507,000 | 0.55% | ||
| 30 | Asset Management One Co., Ltd. | 156,546 | 3,390,000 | 0.54% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 149,738 | 3,282,000 | 0.52% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 140,699 | 3,085,000 | 0.49% | ||
| 33 | BLACKROCK ADVISORS LLC | 127,093 | 2,786,000 | 0.44% | ||
| 34 | CREDIT SUISSE AG/ | 125,477 | 2,751,000 | 0.43% | ||
| 35 | CITADEL ADVISORS LLC | 124,385 | 2,727,000 | 0.43% | ||
| 36 | NORGES BANK | 105,777 | 2,319,000 | 0.37% | ||
| 37 | PRINCIPAL FINANCIAL GROUP INC | 100,198 | 2,197,000 | 0.35% | ||
| 38 | MORGAN STANLEY | 98,073 | 2,150,000 | 0.34% | ||
| 39 | TFS CAPITAL LLC | 91,661 | 2,009,000 | 0.32% | ||
| 40 | Informed Momentum Co LLC | 91,390 | 2,003,000 | 0.32% | ||
| 41 | BBT Capital Management, LLC | 87,911 | 1,927,000 | 0.30% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 87,301 | 1,914,000 | 0.30% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 83,400 | 1,828,000 | 0.29% | Put | |
| 44 | ALLIANCEBERNSTEIN L.P. | 76,690 | 1,681,000 | 0.27% | ||
| 45 | PALISADE CAPITAL MANAGEMENT, LP | 75,000 | 1,644,000 | 0.26% | ||
| 46 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 67,567 | 1,481,000 | 0.23% | ||
| 47 | Overbrook Management Corp | 66,820 | 1,465,000 | 0.23% | ||
| 48 | CITIGROUP INC | 64,290 | 1,410,000 | 0.22% | ||
| 49 | AMERIPRISE FINANCIAL INC | 64,293 | 1,409,000 | 0.22% | ||
| 50 | Swiss National Bank | 62,300 | 1,366,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
