| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 4,512,857 | 93,416,000 | 14.94% | ||
| 2 | BlackRock Fund Advisors | 2,170,992 | 44,940,000 | 7.19% | ||
| 3 | WADDELL & REED FINANCIAL INC | 1,784,482 | 36,939,000 | 5.91% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 1,510,316 | 31,264,000 | 5.00% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,510,000 | 31,257,000 | 5.00% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 1,449,431 | 30,003,000 | 4.80% | ||
| 7 | STATE STREET CORP | 1,301,220 | 26,934,000 | 4.31% | ||
| 8 | JPMORGAN CHASE & CO | 1,077,009 | 22,294,000 | 3.57% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 903,929 | 18,711,000 | 2.99% | ||
| 10 | FMR LLC | 888,903 | 18,401,000 | 2.94% | ||
| 11 | Omega Fund Management, LLC | 822,175 | 17,019,000 | 2.72% | ||
| 12 | EcoR1 Capital, LLC | 686,184 | 14,204,000 | 2.27% | ||
| 13 | NORTHERN TRUST CORP | 602,251 | 12,467,000 | 1.99% | ||
| 14 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 512,655 | 10,612,000 | 1.70% | ||
| 15 | Candriam S.C.A. | 481,000 | 9,957,000 | 1.59% | ||
| 16 | TEACHERS ADVISORS, LLC | 445,357 | 9,219,000 | 1.47% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 414,264 | 8,575,000 | 1.37% | ||
| 18 | PointState Capital LP | 400,000 | 8,280,000 | 1.32% | ||
| 19 | OppenheimerFunds, Inc. | 355,170 | 7,352,000 | 1.18% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 354,206 | 7,332,000 | 1.17% | ||
| 21 | Opaleye Management Inc. | 330,000 | 6,831,000 | 1.09% | ||
| 22 | NORGES BANK | 330,675 | 6,538,000 | 1.05% | ||
| 23 | BANK OF AMERICA CORP /DE/ | 297,470 | 6,158,000 | 0.98% | ||
| 24 | AMERICAN CENTURY COMPANIES INC | 253,736 | 5,252,000 | 0.84% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 249,724 | 5,169,000 | 0.83% | ||
| 26 | Top Ace Asset Management Ltd | 247,399 | 5,121,000 | 0.82% | ||
| 27 | Invesco Ltd. | 241,180 | 4,992,000 | 0.80% | ||
| 28 | Rock Springs Capital Management LP | 233,500 | 4,833,000 | 0.77% | ||
| 29 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 230,350 | 4,768,000 | 0.76% | ||
| 30 | Bank of New York Mellon Corp | 226,643 | 4,692,000 | 0.75% | ||
| 31 | FARALLON CAPITAL MANAGEMENT LLC | 225,000 | 4,658,000 | 0.75% | ||
| 32 | RENAISSANCE TECHNOLOGIES LLC | 223,300 | 4,622,000 | 0.74% | ||
| 33 | HANDELSBANKEN FONDER AB | 199,000 | 4,119,000 | 0.66% | ||
| 34 | JACOBS LEVY EQUITY MANAGEMENT, INC | 198,561 | 4,110,000 | 0.66% | ||
| 35 | BlackRock Investment Management, LLC | 195,199 | 4,041,000 | 0.65% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 173,440 | 3,591,000 | 0.57% | ||
| 37 | ALLIANCEBERNSTEIN L.P. | 151,060 | 3,127,000 | 0.50% | ||
| 38 | SPHERA FUNDS MANAGEMENT LTD. | 145,700 | 3,016,000 | 0.48% | ||
| 39 | CITADEL ADVISORS LLC | 141,130 | 2,921,000 | 0.47% | ||
| 40 | Asset Management One Co., Ltd. | 142,640 | 2,912,000 | 0.47% | ||
| 41 | GOLDMAN SACHS GROUP INC | 139,302 | 2,883,000 | 0.46% | ||
| 42 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 131,848 | 2,729,000 | 0.44% | ||
| 43 | BLACKROCK ADVISORS LLC | 130,044 | 2,692,000 | 0.43% | ||
| 44 | NEXTHERA CAPITAL LP | 127,680 | 2,643,000 | 0.42% | ||
| 45 | DEUTSCHE BANK AG\ | 126,371 | 2,615,000 | 0.42% | ||
| 46 | PRUDENTIAL FINANCIAL INC | 125,780 | 2,604,000 | 0.42% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 110,808 | 2,294,000 | 0.37% | ||
| 48 | PRINCIPAL FINANCIAL GROUP INC | 109,858 | 2,274,000 | 0.36% | ||
| 49 | OXFORD ASSET MANAGEMENT LLP | 106,154 | 2,197,000 | 0.35% | ||
| 50 | Rhenman & Partners Asset Management AB | 104,000 | 2,152,800 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
