| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 5,502,965 | 49,582,000 | 43.44% | ||
| 2 | FMR LLC | 3,228,000 | 29,084,000 | 25.48% | ||
| 3 | Redmile Group, LLC | 943,000 | 8,496,000 | 7.44% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 799,750 | 7,206,000 | 6.31% | ||
| 5 | Rock Springs Capital Management LP | 554,225 | 4,994,000 | 4.38% | ||
| 6 | ORBIMED ADVISORS LLC | 302,300 | 2,724,000 | 2.39% | ||
| 7 | MAZAMA CAPITAL MANAGEMENT INC | 189,414 | 1,707,000 | 1.50% | ||
| 8 | Alyeska Investment Group, L.P. | 175,000 | 1,577,000 | 1.38% | ||
| 9 | TIVERTON ASSET MANAGEMENT LLC | 147,765 | 1,333,000 | 1.17% | ||
| 10 | Pine River Capital Management L.P. | 125,000 | 1,125,000 | 0.99% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 122,478 | 1,104,000 | 0.97% | ||
| 12 | Laurion Capital Management LP | 105,000 | 946,000 | 0.83% | ||
| 13 | LEVIN CAPITAL STRATEGIES, L.P. | 95,000 | 856,000 | 0.75% | ||
| 14 | FRIESS ASSOCIATES LLC | 76,800 | 692,000 | 0.61% | ||
| 15 | JPMORGAN CHASE & CO | 75,275 | 679,000 | 0.59% | ||
| 16 | DECADE CAPITAL MANAGEMENT LLC | 45,100 | 406,000 | 0.36% | ||
| 17 | Grandeur Peak Global Advisors, LLC | 39,000 | 351,000 | 0.31% | ||
| 18 | ARROWGRASS CAPITAL PARTNERS (US) LP | 33,560 | 302,000 | 0.26% | ||
| 19 | GOLDMAN SACHS GROUP INC | 33,175 | 299,000 | 0.26% | ||
| 20 | DEUTSCHE BANK AG\ | 32,408 | 291,000 | 0.25% | ||
| 21 | Connective Capital Management, LLC | 28,500 | 257,000 | 0.23% | ||
| 22 | TWO SIGMA SECURITIES, LLC | 12,541 | 113,000 | 0.10% | ||
| 23 | MORGAN STANLEY | 1,437 | 13,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
