| 1 |
GREAT POINT PARTNERS LLC |
4,127,232 |
10,566,000 |
36.57% |
|
|
| 2 |
FMR LLC |
3,234,761 |
8,281,000 |
28.66% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,740,000 |
4,454,000 |
15.42% |
|
|
| 4 |
AlphaOne Investment Services, LLC |
344,334 |
882,000 |
3.05% |
|
|
| 5 |
VANGUARD GROUP INC |
340,904 |
873,000 |
3.02% |
|
|
| 6 |
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
259,642 |
665,000 |
2.30% |
|
|
| 7 |
BlackRock Fund Advisors |
172,719 |
442,000 |
1.53% |
|
|
| 8 |
LEVIN CAPITAL STRATEGIES, L.P. |
109,068 |
279,000 |
0.97% |
|
|
| 9 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
80,200 |
205,000 |
0.71% |
|
|
| 10 |
NORTHERN TRUST CORP |
68,155 |
175,000 |
0.61% |
|
|
| 11 |
GUGGENHEIM CAPITAL LLC |
66,202 |
169,000 |
0.58% |
|
|
| 12 |
TIVERTON ASSET MANAGEMENT LLC |
64,922 |
166,000 |
0.57% |
|
|
| 13 |
MONTAG A & ASSOCIATES INC |
62,277 |
159,000 |
0.55% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
50,907 |
130,000 |
0.45% |
|
|
| 15 |
Spark Investment Management LLC |
49,100 |
125,000 |
0.43% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
45,644 |
117,000 |
0.40% |
|
|
| 17 |
RENAISSANCE TECHNOLOGIES LLC |
36,760 |
94,000 |
0.33% |
|
|
| 18 |
Lenox Wealth Management, Inc. |
35,886 |
92,000 |
0.32% |
|
|
| 19 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
34,600 |
89,000 |
0.31% |
|
|
| 20 |
STATE STREET CORP |
31,500 |
83,000 |
0.29% |
|
|
| 21 |
D. E. Shaw & Co., Inc. |
31,714 |
81,000 |
0.28% |
|
|
| 22 |
BlackRock Investment Management, LLC |
24,577 |
63,000 |
0.22% |
|
|
| 23 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
23,804 |
61,000 |
0.21% |
|
|
| 24 |
ROYCE & ASSOCIATES LP |
20,000 |
51,000 |
0.18% |
|
|
| 25 |
DEUTSCHE BANK AG\ |
19,578 |
49,000 |
0.17% |
|
|
| 26 |
Bank of New York Mellon Corp |
18,956 |
48,000 |
0.17% |
|
|
| 27 |
BLUE CREEK INVESTMENT PARTNERS, LLC |
18,750 |
48,000 |
0.17% |
|
|
| 28 |
Southeast Asset Advisors, LLC |
15,710 |
40,000 |
0.14% |
|
|
| 29 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
15,123 |
39,000 |
0.13% |
|
|
| 30 |
A.R.T. Advisors, LLC |
14,602 |
37,000 |
0.13% |
|
|
| 31 |
BLAIR WILLIAM & CO/IL |
14,187 |
36,000 |
0.12% |
|
|
| 32 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,900 |
36,000 |
0.12% |
|
|
| 33 |
GOLDMAN SACHS GROUP INC |
13,548 |
35,000 |
0.12% |
|
|
| 34 |
WELLS FARGO & COMPANY/MN |
13,582 |
34,000 |
0.12% |
|
|
| 35 |
Brown Advisory Securities, LLC |
11,111 |
28,000 |
0.10% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
9,214 |
24,000 |
0.08% |
|
|
| 37 |
MORGAN STANLEY |
6,965 |
18,000 |
0.06% |
|
|
| 38 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,100 |
16,000 |
0.06% |
|
|
| 39 |
CITIGROUP INC |
5,427 |
14,000 |
0.05% |
|
|
| 40 |
TD Capital Management LLC |
5,625 |
14,000 |
0.05% |
|
|
| 41 |
KINGS POINT CAPITAL MANAGEMENT |
4,500 |
12,000 |
0.04% |
|
|
| 42 |
BANK OF AMERICA CORP /DE/ |
4,791 |
12,000 |
0.04% |
|
|
| 43 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,889 |
10,000 |
0.03% |
|
|
| 44 |
Nationwide Fund Advisors |
3,725 |
10,000 |
0.03% |
|
|
| 45 |
CAPITAL GUARDIAN TRUST CO |
3,125 |
8,000 |
0.03% |
|
|
| 46 |
BLACKROCK ADVISORS LLC |
2,006 |
5,000 |
0.02% |
|
|
| 47 |
First Horizon Advisors, Inc. |
1,875 |
5,000 |
0.02% |
|
|
| 48 |
Creative Planning |
2,000 |
5,000 |
0.02% |
|
|
| 49 |
Tower Research Capital LLC (TRC) |
989 |
3,000 |
0.01% |
|
|
| 50 |
BlackRock Japan Co. Ltd |
725 |
2,000 |
0.01% |
|
|
