| 1 |
GREAT POINT PARTNERS LLC |
4,127,232 |
18,820,000 |
34.02% |
|
|
| 2 |
FMR LLC |
3,250,000 |
14,820,000 |
26.79% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,740,000 |
7,934,000 |
14.34% |
|
|
| 4 |
TIVERTON ASSET MANAGEMENT LLC |
500,000 |
2,280,000 |
4.12% |
|
|
| 5 |
Rock Springs Capital Management LP |
365,000 |
1,664,000 |
3.01% |
|
|
| 6 |
AlphaOne Investment Services, LLC |
352,787 |
1,608,000 |
2.91% |
|
|
| 7 |
VANGUARD GROUP INC |
303,329 |
1,383,000 |
2.50% |
|
|
| 8 |
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
253,650 |
1,157,000 |
2.09% |
|
|
| 9 |
BlackRock Fund Advisors |
177,622 |
810,000 |
1.46% |
|
|
| 10 |
GUGGENHEIM CAPITAL LLC |
148,329 |
677,000 |
1.22% |
|
|
| 11 |
WHITEBOX ADVISORS LLC |
71,148 |
324,000 |
0.59% |
|
|
| 12 |
NORTHERN TRUST CORP |
68,155 |
311,000 |
0.56% |
|
|
| 13 |
MONTAG A & ASSOCIATES INC |
64,027 |
292,000 |
0.53% |
|
|
| 14 |
LEVIN CAPITAL STRATEGIES, L.P. |
55,237 |
252,000 |
0.46% |
|
|
| 15 |
MILLENNIUM MANAGEMENT LLC |
53,388 |
243,000 |
0.44% |
|
|
| 16 |
MORGAN STANLEY |
51,393 |
234,000 |
0.42% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
50,830 |
231,000 |
0.42% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
45,496 |
207,000 |
0.37% |
|
|
| 19 |
WELLS FARGO & COMPANY/MN |
43,336 |
197,000 |
0.36% |
|
|
| 20 |
FRIESS ASSOCIATES LLC |
39,093 |
178,000 |
0.32% |
|
|
| 21 |
Harvest Capital Strategies LLC |
37,000 |
169,000 |
0.31% |
|
|
| 22 |
D. E. Shaw & Co., Inc. |
34,404 |
157,000 |
0.28% |
|
|
| 23 |
CITADEL ADVISORS LLC |
33,729 |
154,000 |
0.28% |
|
|
| 24 |
STATE STREET CORP |
31,518 |
144,000 |
0.26% |
|
|
| 25 |
BANK OF AMERICA CORP /DE/ |
29,323 |
134,000 |
0.24% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
23,804 |
109,000 |
0.20% |
|
|
| 27 |
BlackRock Investment Management, LLC |
23,720 |
108,000 |
0.20% |
|
|
| 28 |
ROYCE & ASSOCIATES LP |
20,000 |
91,000 |
0.16% |
|
|
| 29 |
Bank of New York Mellon Corp |
17,726 |
81,000 |
0.15% |
|
|
| 30 |
Brown Advisory Securities, LLC |
16,975 |
77,000 |
0.14% |
|
|
| 31 |
Southeast Asset Advisors, LLC |
15,710 |
72,000 |
0.13% |
|
|
| 32 |
BLAIR WILLIAM & CO/IL |
15,342 |
69,000 |
0.12% |
|
|
| 33 |
MENTA CAPITAL LLC |
14,835 |
68,000 |
0.12% |
|
|
| 34 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,900 |
64,000 |
0.12% |
|
|
| 35 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,119 |
55,000 |
0.10% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
9,214 |
42,000 |
0.08% |
|
|
| 37 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,100 |
28,000 |
0.05% |
|
|
| 38 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,896 |
18,000 |
0.03% |
|
|
| 39 |
BLACKROCK ADVISORS LLC |
3,751 |
17,000 |
0.03% |
|
|
| 40 |
Nationwide Fund Advisors |
3,725 |
17,000 |
0.03% |
|
|
| 41 |
Creative Planning |
2,000 |
9,000 |
0.02% |
|
|
| 42 |
DEUTSCHE BANK AG\ |
1,869 |
8,000 |
0.01% |
|
|
| 43 |
BNP PARIBAS FINANCIAL MARKETS |
1,640 |
7,478 |
0.01% |
|
|
| 44 |
PNC FINANCIAL SERVICES GROUP, INC. |
72 |
0 |
0.00% |
|
|
| 45 |
BARCLAYS PLC |
34 |
0 |
0.00% |
|
|
| 46 |
CITIGROUP INC |
1 |
0 |
0.00% |
|
|
