| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 5,502,965 | 56,956,000 | 42.42% | ||
| 2 | FMR LLC | 3,250,000 | 33,638,000 | 25.05% | ||
| 3 | ORBIMED ADVISORS LLC | 1,740,000 | 18,009,000 | 13.41% | ||
| 4 | Rock Springs Capital Management LP | 600,000 | 6,210,000 | 4.62% | ||
| 5 | TIVERTON ASSET MANAGEMENT LLC | 500,000 | 5,175,000 | 3.85% | ||
| 6 | VANGUARD GROUP INC | 260,915 | 2,700,000 | 2.01% | ||
| 7 | BlackRock Fund Advisors | 182,737 | 1,891,000 | 1.41% | ||
| 8 | Harvest Capital Strategies LLC | 137,444 | 1,423,000 | 1.06% | ||
| 9 | MORGAN STANLEY | 115,232 | 1,193,000 | 0.89% | ||
| 10 | LEVIN CAPITAL STRATEGIES, L.P. | 93,700 | 970,000 | 0.72% | ||
| 11 | FRIESS ASSOCIATES LLC | 80,690 | 835,000 | 0.62% | ||
| 12 | MAZAMA CAPITAL MANAGEMENT INC | 68,210 | 706,000 | 0.53% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 67,648 | 700,000 | 0.52% | ||
| 14 | CITADEL ADVISORS LLC | 65,154 | 675,000 | 0.50% | ||
| 15 | D. E. Shaw & Co., Inc. | 51,221 | 530,000 | 0.39% | ||
| 16 | GOLDMAN SACHS GROUP INC | 49,574 | 513,000 | 0.38% | ||
| 17 | Connective Capital Management, LLC | 48,053 | 497,000 | 0.37% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 26,379 | 273,000 | 0.20% | ||
| 19 | ROYCE & ASSOCIATES LP | 20,000 | 207,000 | 0.15% | ||
| 20 | BlackRock Investment Management, LLC | 19,145 | 198,000 | 0.15% | ||
| 21 | Grandeur Peak Global Advisors, LLC | 17,750 | 184,000 | 0.14% | ||
| 22 | NORTHERN TRUST CORP | 17,268 | 179,000 | 0.13% | ||
| 23 | BlackRock Group LTD | 15,332 | 159,000 | 0.12% | ||
| 24 | Bank of New York Mellon Corp | 12,125 | 125,000 | 0.09% | ||
| 25 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,100 | 125,000 | 0.09% | ||
| 26 | TEACHERS ADVISORS, LLC | 6,408 | 66,000 | 0.05% | ||
| 27 | CITIGROUP INC | 4,097 | 42,000 | 0.03% | ||
| 28 | BLACKROCK ADVISORS LLC | 2,784 | 29,000 | 0.02% | ||
| 29 | STRS OHIO | 2,200 | 22,000 | 0.02% | ||
| 30 | Nationwide Fund Advisors | 1,421 | 15,000 | 0.01% | ||
| 31 | Tower Research Capital LLC (TRC) | 1,321 | 14,000 | 0.01% | ||
| 32 | PRELUDE CAPITAL MANAGEMENT, LLC | 839 | 9,000 | 0.01% | ||
| 33 | WELLS FARGO & COMPANY/MN | 632 | 7,000 | 0.01% | ||
| 34 | THOMPSON DAVIS & CO., INC. | 250 | 3,000 | 0.00% | ||
| 35 | BNP PARIBAS FINANCIAL MARKETS | 158 | 1,635 | 0.00% | ||
| 36 | ROYAL BANK OF CANADA | 100 | 1,000 | 0.00% | ||
| 37 | BARCLAYS PLC | 87 | 1,000 | 0.00% | ||
| 38 | UBS Group AG | 137 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
