| 1 |
GREAT POINT PARTNERS LLC |
4,127,232 |
14,899,000 |
34.85% |
|
|
| 2 |
FMR LLC |
3,234,761 |
11,677,000 |
27.32% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,740,000 |
6,281,000 |
14.69% |
|
|
| 4 |
AlphaOne Investment Services, LLC |
401,434 |
1,450,000 |
3.39% |
|
|
| 5 |
TIVERTON ASSET MANAGEMENT LLC |
400,000 |
1,444,000 |
3.38% |
|
|
| 6 |
VANGUARD GROUP INC |
330,959 |
1,195,000 |
2.80% |
|
|
| 7 |
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
260,042 |
939,000 |
2.20% |
|
|
| 8 |
LEVIN CAPITAL STRATEGIES, L.P. |
204,101 |
737,000 |
1.72% |
|
|
| 9 |
BlackRock Fund Advisors |
182,611 |
659,000 |
1.54% |
|
|
| 10 |
FORMULA GROWTH LTD |
179,130 |
647,000 |
1.51% |
|
|
| 11 |
GUGGENHEIM CAPITAL LLC |
98,025 |
354,000 |
0.83% |
|
|
| 12 |
NORTHERN TRUST CORP |
68,155 |
246,000 |
0.58% |
|
|
| 13 |
MONTAG A & ASSOCIATES INC |
62,277 |
225,000 |
0.53% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
50,984 |
184,000 |
0.43% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
46,381 |
167,000 |
0.39% |
|
|
| 16 |
Spark Investment Management LLC |
45,000 |
162,000 |
0.38% |
|
|
| 17 |
MILLENNIUM MANAGEMENT LLC |
35,766 |
129,000 |
0.30% |
|
|
| 18 |
Lenox Wealth Management, Inc. |
35,821 |
129,000 |
0.30% |
|
|
| 19 |
D. E. Shaw & Co., Inc. |
34,990 |
126,000 |
0.29% |
|
|
| 20 |
STATE STREET CORP |
31,518 |
113,000 |
0.26% |
|
|
| 21 |
BlackRock Investment Management, LLC |
23,998 |
87,000 |
0.20% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
23,804 |
86,000 |
0.20% |
|
|
| 23 |
MORGAN STANLEY |
20,720 |
74,000 |
0.17% |
|
|
| 24 |
ROYCE & ASSOCIATES LP |
20,000 |
72,000 |
0.17% |
|
|
| 25 |
Bank of New York Mellon Corp |
18,956 |
68,000 |
0.16% |
|
|
| 26 |
A.R.T. Advisors, LLC |
17,217 |
62,000 |
0.15% |
|
|
| 27 |
Southeast Asset Advisors, LLC |
15,710 |
57,000 |
0.13% |
|
|
| 28 |
BLAIR WILLIAM & CO/IL |
15,347 |
55,000 |
0.13% |
|
|
| 29 |
SG Americas Securities, LLC |
14,804 |
53,000 |
0.12% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,900 |
51,000 |
0.12% |
|
|
| 31 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,319 |
44,000 |
0.10% |
|
|
| 32 |
GOLDMAN SACHS GROUP INC |
11,758 |
42,000 |
0.10% |
|
|
| 33 |
Brown Advisory Securities, LLC |
11,111 |
40,000 |
0.09% |
|
|
| 34 |
Crosspoint Capital Strategies, LLC |
10,133 |
37,000 |
0.09% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
9,214 |
33,000 |
0.08% |
|
|
| 36 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,100 |
22,000 |
0.05% |
|
|
| 37 |
BANK OF AMERICA CORP /DE/ |
4,951 |
18,000 |
0.04% |
|
|
| 38 |
KINGS POINT CAPITAL MANAGEMENT |
4,500 |
16,000 |
0.04% |
|
|
| 39 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,889 |
14,000 |
0.03% |
|
|
| 40 |
Nationwide Fund Advisors |
3,725 |
13,000 |
0.03% |
|
|
| 41 |
UBS Group AG |
2,090 |
8,000 |
0.02% |
|
|
| 42 |
Creative Planning |
2,000 |
7,000 |
0.02% |
|
|
| 43 |
CITIGROUP INC |
2,012 |
7,000 |
0.02% |
|
|
| 44 |
BLACKROCK ADVISORS LLC |
2,006 |
7,000 |
0.02% |
|
|
| 45 |
DEUTSCHE BANK AG\ |
1,678 |
5,000 |
0.01% |
|
|
| 46 |
BlackRock Japan Co. Ltd |
725 |
3,000 |
0.01% |
|
|
| 47 |
BNP PARIBAS FINANCIAL MARKETS |
807 |
2,913 |
0.01% |
|
|
| 48 |
WELLS FARGO & COMPANY/MN |
503 |
2,000 |
0.00% |
|
|
| 49 |
PNC FINANCIAL SERVICES GROUP, INC. |
72 |
0 |
0.00% |
|
|
