| 1 |
GREAT POINT PARTNERS LLC |
4,127,232 |
43,584,000 |
34.00% |
|
|
| 2 |
FMR LLC |
3,250,000 |
34,320,000 |
26.78% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,740,000 |
18,374,000 |
14.34% |
|
|
| 4 |
Rock Springs Capital Management LP |
625,000 |
6,600,000 |
5.15% |
|
|
| 5 |
TIVERTON ASSET MANAGEMENT LLC |
500,000 |
5,280,000 |
4.12% |
|
|
| 6 |
VANGUARD GROUP INC |
274,693 |
2,901,000 |
2.26% |
|
|
| 7 |
BLAIR WILLIAM & CO/IL |
249,169 |
2,630,000 |
2.05% |
|
|
| 8 |
BlackRock Fund Advisors |
179,748 |
1,898,000 |
1.48% |
|
|
| 9 |
GUGGENHEIM CAPITAL LLC |
140,720 |
1,485,000 |
1.16% |
|
|
| 10 |
Informed Momentum Co LLC |
133,120 |
1,406,000 |
1.10% |
|
|
| 11 |
FRIESS ASSOCIATES LLC |
76,540 |
808,000 |
0.63% |
|
|
| 12 |
CITADEL ADVISORS LLC |
75,087 |
793,000 |
0.62% |
|
|
| 13 |
MONTAG A & ASSOCIATES INC |
62,027 |
655,000 |
0.51% |
|
|
| 14 |
WHITEBOX ADVISORS LLC |
59,451 |
628,000 |
0.49% |
|
|
| 15 |
MORGAN STANLEY |
57,234 |
605,000 |
0.47% |
|
|
| 16 |
Kessler Investment Group, LLC |
52,114 |
550,000 |
0.43% |
|
|
| 17 |
NORTHERN TRUST CORP |
45,228 |
477,000 |
0.37% |
|
|
| 18 |
Harvest Capital Strategies LLC |
45,000 |
475,000 |
0.37% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
44,167 |
466,000 |
0.36% |
|
|
| 20 |
WELLS FARGO & COMPANY/MN |
43,641 |
461,000 |
0.36% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
40,383 |
426,000 |
0.33% |
|
|
| 22 |
D. E. Shaw & Co., Inc. |
31,113 |
329,000 |
0.26% |
|
|
| 23 |
LEVIN CAPITAL STRATEGIES, L.P. |
29,237 |
309,000 |
0.24% |
|
|
| 24 |
STATE STREET CORP |
27,608 |
291,000 |
0.23% |
|
|
| 25 |
Brown Advisory Securities, LLC |
25,061 |
265,000 |
0.21% |
|
|
| 26 |
BlackRock Investment Management, LLC |
23,994 |
253,000 |
0.20% |
|
|
| 27 |
GOLDMAN SACHS GROUP INC |
23,885 |
252,000 |
0.20% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
23,804 |
251,000 |
0.20% |
|
|
| 29 |
Bank of New York Mellon Corp |
22,717 |
240,000 |
0.19% |
|
|
| 30 |
Southeast Asset Advisors, LLC |
21,410 |
226,000 |
0.18% |
|
|
| 31 |
ROYCE & ASSOCIATES LP |
20,000 |
211,000 |
0.16% |
|
|
| 32 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,900 |
147,000 |
0.11% |
|
|
| 33 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,119 |
128,000 |
0.10% |
|
|
| 34 |
TEACHERS ADVISORS, LLC |
9,214 |
97,000 |
0.08% |
|
|
| 35 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,121 |
75,000 |
0.06% |
|
|
| 36 |
DEUTSCHE BANK AG\ |
5,130 |
53,000 |
0.04% |
|
|
| 37 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,892 |
41,100 |
0.03% |
|
|
| 38 |
BLACKROCK ADVISORS LLC |
3,751 |
40,000 |
0.03% |
|
|
| 39 |
Nationwide Fund Advisors |
3,725 |
39,000 |
0.03% |
|
|
| 40 |
MAZAMA CAPITAL MANAGEMENT INC |
2,983 |
32,000 |
0.02% |
|
|
| 41 |
UBS Group AG |
2,252 |
24,000 |
0.02% |
|
|
| 42 |
BARCLAYS PLC |
1,627 |
16,000 |
0.01% |
|
|
| 43 |
Invesco Ltd. |
671 |
7,000 |
0.01% |
|
|
| 44 |
BNP PARIBAS FINANCIAL MARKETS |
553 |
5,840 |
0.00% |
|
|
| 45 |
ROYAL BANK OF CANADA |
452 |
5,000 |
0.00% |
|
|
| 46 |
BlackRock Group LTD |
335 |
4,000 |
0.00% |
|
|
| 47 |
BANK OF AMERICA CORP /DE/ |
237 |
3,000 |
0.00% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
242 |
3,000 |
0.00% |
|
|
| 49 |
THOMPSON DAVIS & CO., INC. |
250 |
3,000 |
0.00% |
|
|
| 50 |
PNC FINANCIAL SERVICES GROUP, INC. |
70 |
1,000 |
0.00% |
|
|
