| 1 |
Clarus Ventures, LLC |
1,071,429 |
9,643,000 |
37.68% |
|
|
| 2 |
CLIFTON PARK CAPITAL MANAGEMENT, LLC |
680,000 |
6,120,000 |
23.91% |
|
|
| 3 |
Amici Capital, LLC |
300,000 |
2,700,000 |
10.55% |
|
|
| 4 |
DAFNA Capital Management LLC |
184,187 |
1,658,000 |
6.48% |
|
SH |
| 5 |
Alyeska Investment Group, L.P. |
130,092 |
1,171,000 |
4.58% |
|
|
| 6 |
FARALLON CAPITAL MANAGEMENT LLC |
125,000 |
1,125,000 |
4.40% |
|
|
| 7 |
VANGUARD GROUP INC |
76,854 |
691,000 |
2.70% |
|
|
| 8 |
PIPER SANDLER & CO. |
52,792 |
475,000 |
1.86% |
|
|
| 9 |
GOLDMAN SACHS GROUP INC |
44,826 |
403,000 |
1.57% |
|
|
| 10 |
Ghost Tree Capital, LLC |
43,000 |
387,000 |
1.51% |
|
|
| 11 |
BlackRock Fund Advisors |
25,753 |
232,000 |
0.91% |
|
|
| 12 |
Geduld E E |
25,000 |
225,000 |
0.88% |
|
|
| 13 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
21,698 |
195,000 |
0.76% |
|
|
| 14 |
PERCEPTIVE ADVISORS LLC |
20,000 |
180,000 |
0.70% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
16,119 |
145,000 |
0.57% |
|
|
| 16 |
Spark Investment Management LLC |
15,900 |
142,000 |
0.55% |
|
|
| 17 |
MORGAN STANLEY |
4,160 |
37,000 |
0.14% |
|
|
| 18 |
BlackRock Investment Management, LLC |
2,251 |
20,000 |
0.08% |
|
|
| 19 |
PNC FINANCIAL SERVICES GROUP, INC. |
2,000 |
18,000 |
0.07% |
|
|
| 20 |
BLACKROCK ADVISORS LLC |
1,077 |
10,000 |
0.04% |
|
|
| 21 |
Parallax Volatility Advisers, L.P. |
501 |
5,000 |
0.02% |
|
|
| 22 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
700 |
4,000 |
0.02% |
|
|
| 23 |
DEUTSCHE BANK AG\ |
400 |
3,000 |
0.01% |
|
|
| 24 |
WELLS FARGO & COMPANY/MN |
200 |
2,000 |
0.01% |
|
|
