| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,122,775 | 66,034,000 | 9.92% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 6,000,000 | 64,710,000 | 9.72% | Call | |
| 3 | GOLDMAN SACHS GROUP INC | 3,949,200 | 42,592,000 | 6.40% | Call | |
| 4 | WASATCH ADVISORS LP | 2,970,812 | 32,040,000 | 4.81% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,550,000 | 27,502,000 | 4.13% | ||
| 6 | STATE STREET CORP | 2,533,186 | 27,318,000 | 4.10% | ||
| 7 | BlackRock Fund Advisors | 2,300,729 | 24,813,000 | 3.73% | ||
| 8 | FRONTIER CAPITAL MANAGEMENT CO LLC | 2,152,179 | 23,211,000 | 3.49% | ||
| 9 | VANGUARD GROUP INC | 2,043,798 | 22,042,000 | 3.31% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,961,386 | 21,154,000 | 3.18% | ||
| 11 | JENNISON ASSOCIATES LLC | 1,768,392 | 19,072,000 | 2.87% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,720,700 | 18,558,000 | 2.79% | Call | |
| 13 | JANUS HENDERSON INVESTORS US LLC | 1,306,092 | 14,086,000 | 2.12% | ||
| 14 | RA CAPITAL MANAGEMENT, L.P. | 1,220,209 | 13,160,000 | 1.98% | ||
| 15 | BAKER BROS. ADVISORS LP | 864,856 | 9,327,000 | 1.40% | ||
| 16 | NORTHERN TRUST CORP | 810,524 | 8,742,000 | 1.31% | ||
| 17 | PERCEPTIVE ADVISORS LLC | 800,000 | 8,628,000 | 1.30% | ||
| 18 | EverPoint Asset Management, LLC | 800,000 | 8,628,000 | 1.30% | ||
| 19 | FRANKLIN RESOURCES INC | 769,800 | 8,302,000 | 1.25% | ||
| 20 | FIC CAPITAL INC | 759,154 | 8,187,000 | 1.23% | ||
| 21 | Tekla Capital Management LLC | 750,100 | 8,090,000 | 1.22% | ||
| 22 | Point72 Asset Management, L.P. | 641,500 | 6,919,000 | 1.04% | ||
| 23 | TIVERTON ASSET MANAGEMENT LLC | 606,800 | 6,546,000 | 0.98% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 545,036 | 5,878,000 | 0.88% | ||
| 25 | First Eagle Investment Management, LLC | 536,380 | 5,785,000 | 0.87% | ||
| 26 | Cormorant Asset Management, LP | 500,000 | 5,393,000 | 0.81% | ||
| 27 | Point72 Asset Management, L.P. | 488,400 | 5,267,000 | 0.79% | Call | |
| 28 | MORGAN STANLEY | 485,113 | 5,232,000 | 0.79% | ||
| 29 | EVENTIDE ASSET MANAGEMENT, LLC | 482,500 | 5,204,000 | 0.78% | ||
| 30 | GOLDMAN SACHS GROUP INC | 468,553 | 5,053,000 | 0.76% | ||
| 31 | MARXE AUSTIN W & GREENHOUSE DAVID M | 450,000 | 4,853,000 | 0.73% | ||
| 32 | CITY NATIONAL BANK | 449,194 | 4,845,000 | 0.73% | ||
| 33 | WELLINGTON MANAGEMENT GROUP LLP | 448,480 | 4,836,000 | 0.73% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 445,345 | 4,803,000 | 0.72% | ||
| 35 | SABBY MANAGEMENT, LLC | 420,123 | 4,531,000 | 0.68% | ||
| 36 | D. E. Shaw & Co., Inc. | 379,311 | 4,091,000 | 0.61% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 378,588 | 4,083,000 | 0.61% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 376,475 | 4,060,000 | 0.61% | ||
| 39 | Bank of New York Mellon Corp | 366,314 | 3,951,000 | 0.59% | ||
| 40 | Numeric Investors LLC | 354,816 | 3,827,000 | 0.58% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 341,100 | 3,679,000 | 0.55% | Put | |
| 42 | ALTRINSIC GLOBAL ADVISORS LLC | 340,000 | 3,667,000 | 0.55% | ||
| 43 | Allianz Asset Management GmbH | 303,291 | 3,271,000 | 0.49% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 301,034 | 3,247,000 | 0.49% | ||
| 45 | Private Capital Advisors, Inc. | 298,000 | 3,214,000 | 0.48% | ||
| 46 | CREDIT SUISSE AG/ | 295,657 | 3,189,000 | 0.48% | ||
| 47 | LORD, ABBETT & CO. LLC | 286,667 | 3,092,000 | 0.46% | ||
| 48 | BLACKROCK ADVISORS LLC | 285,377 | 3,078,000 | 0.46% | ||
| 49 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 250,298 | 2,699,000 | 0.41% | ||
| 50 | DEUTSCHE BANK AG\ | 241,209 | 2,599,000 | 0.39% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
