| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,122,775 | 110,700,000 | 9.92% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 6,000,000 | 108,480,000 | 9.72% | Call | |
| 3 | RA CAPITAL MANAGEMENT, L.P. | 5,222,053 | 94,415,000 | 8.46% | ||
| 4 | GOLDMAN SACHS GROUP INC | 3,949,200 | 71,402,000 | 6.40% | Call | |
| 5 | WASATCH ADVISORS LP | 3,125,160 | 56,503,000 | 5.06% | ||
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,800,000 | 50,624,000 | 4.54% | ||
| 7 | BlackRock Fund Advisors | 2,631,654 | 47,580,000 | 4.26% | ||
| 8 | JENNISON ASSOCIATES LLC | 2,016,213 | 36,453,000 | 3.27% | ||
| 9 | VANGUARD GROUP INC | 1,958,622 | 35,412,000 | 3.17% | ||
| 10 | STATE STREET CORP | 1,901,499 | 34,378,000 | 3.08% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,854,500 | 33,529,000 | 3.00% | Call | |
| 12 | BlackRock Institutional Trust Company, N.A. | 1,814,939 | 32,814,000 | 2.94% | ||
| 13 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,317,190 | 23,815,000 | 2.13% | ||
| 14 | FRANKLIN RESOURCES INC | 1,096,100 | 19,817,000 | 1.78% | ||
| 15 | Invesco Ltd. | 988,093 | 17,865,000 | 1.60% | ||
| 16 | NORTHERN TRUST CORP | 861,346 | 15,573,000 | 1.40% | ||
| 17 | PERCEPTIVE ADVISORS LLC | 800,000 | 14,464,000 | 1.30% | ||
| 18 | JANUS HENDERSON INVESTORS US LLC | 784,077 | 14,176,000 | 1.27% | ||
| 19 | FIC CAPITAL INC | 736,309 | 13,312,000 | 1.19% | ||
| 20 | TimesSquare Capital Management, LLC | 660,900 | 11,949,000 | 1.07% | ||
| 21 | TIVERTON ASSET MANAGEMENT LLC | 606,800 | 10,971,000 | 0.98% | ||
| 22 | Cormorant Asset Management, LP | 600,000 | 10,848,000 | 0.97% | ||
| 23 | BAKER BROS. ADVISORS LP | 522,764 | 9,452,000 | 0.85% | ||
| 24 | SAC Capital Advisors LP | 509,662 | 9,215,000 | 0.83% | ||
| 25 | MORGAN STANLEY | 485,275 | 8,774,000 | 0.79% | ||
| 26 | EVENTIDE ASSET MANAGEMENT, LLC | 462,500 | 8,362,000 | 0.75% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 459,000 | 8,299,000 | 0.74% | Put | |
| 28 | MARXE AUSTIN W & GREENHOUSE DAVID M | 450,000 | 8,136,000 | 0.73% | ||
| 29 | GOLDMAN SACHS GROUP INC | 412,284 | 7,454,000 | 0.67% | ||
| 30 | First Eagle Investment Management, LLC | 400,000 | 7,232,000 | 0.65% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 366,361 | 6,623,000 | 0.59% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 365,948 | 6,617,000 | 0.59% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 357,024 | 6,455,000 | 0.58% | ||
| 34 | Bank of New York Mellon Corp | 349,890 | 6,325,000 | 0.57% | ||
| 35 | BARCLAYS PLC | 343,000 | 6,174,000 | 0.55% | Call | |
| 36 | Allianz Asset Management GmbH | 327,714 | 5,925,000 | 0.53% | ||
| 37 | BARCLAYS PLC | 319,200 | 5,746,000 | 0.51% | Put | |
| 38 | FIL Ltd | 305,605 | 5,525,000 | 0.50% | ||
| 39 | HealthCor Management, L.P. | 300,000 | 5,424,000 | 0.49% | Put | |
| 40 | BALYASNY ASSET MANAGEMENT L.P. | 276,600 | 5,001,000 | 0.45% | ||
| 41 | LORD, ABBETT & CO. LLC | 268,126 | 4,848,000 | 0.43% | ||
| 42 | Cupps Capital Management, LLC | 256,979 | 4,646,000 | 0.42% | ||
| 43 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 240,298 | 4,345,000 | 0.39% | ||
| 44 | ALTRINSIC GLOBAL ADVISORS LLC | 240,000 | 4,339,000 | 0.39% | ||
| 45 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 230,000 | 4,158,000 | 0.37% | ||
| 46 | CITY NATIONAL BANK | 207,289 | 3,748,000 | 0.34% | ||
| 47 | BlackRock Investment Management, LLC | 183,894 | 3,325,000 | 0.30% | ||
| 48 | GUGGENHEIM CAPITAL LLC | 182,540 | 3,300,000 | 0.30% | ||
| 49 | SABBY MANAGEMENT, LLC | 177,265 | 3,205,000 | 0.29% | ||
| 50 | CREDIT SUISSE AG/ | 176,523 | 3,192,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
