| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 6,000,000 | 66,540,000 | 9.61% | Call | |
| 2 | FMR LLC | 4,269,815 | 47,352,000 | 6.84% | ||
| 3 | GOLDMAN SACHS GROUP INC | 3,880,000 | 43,029,000 | 6.22% | Call | |
| 4 | STATE STREET CORP | 3,400,985 | 37,720,000 | 5.45% | ||
| 5 | BAKER BROS. ADVISORS LP | 3,230,932 | 35,831,000 | 5.18% | ||
| 6 | WASATCH ADVISORS LP | 3,091,386 | 34,283,000 | 4.95% | ||
| 7 | BlackRock Fund Advisors | 2,561,830 | 28,411,000 | 4.11% | ||
| 8 | VANGUARD GROUP INC | 2,331,734 | 25,859,000 | 3.74% | ||
| 9 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,901,604 | 21,089,000 | 3.05% | ||
| 10 | Bank of New York Mellon Corp | 1,879,927 | 20,848,000 | 3.01% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,825,637 | 20,246,000 | 2.93% | ||
| 12 | JENNISON ASSOCIATES LLC | 1,731,499 | 19,202,000 | 2.77% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,528,300 | 16,949,000 | 2.45% | Call | |
| 14 | Invesco Ltd. | 1,356,752 | 15,047,000 | 2.17% | ||
| 15 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,350,000 | 14,972,000 | 2.16% | ||
| 16 | RA CAPITAL MANAGEMENT, L.P. | 1,220,209 | 13,532,000 | 1.96% | ||
| 17 | VOYA INVESTMENT MANAGEMENT LLC | 970,753 | 10,766,000 | 1.56% | ||
| 18 | GOLDMAN SACHS GROUP INC | 945,225 | 10,483,000 | 1.51% | ||
| 19 | PERCEPTIVE ADVISORS LLC | 800,000 | 8,872,000 | 1.28% | ||
| 20 | FIC CAPITAL INC | 787,529 | 8,734,000 | 1.26% | ||
| 21 | NORTHERN TRUST CORP | 785,933 | 8,716,000 | 1.26% | ||
| 22 | COLUMBUS CIRCLE INVESTORS | 778,065 | 8,629,000 | 1.25% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 765,665 | 8,491,000 | 1.23% | ||
| 24 | FRANKLIN RESOURCES INC | 716,300 | 7,944,000 | 1.15% | ||
| 25 | DEUTSCHE BANK AG\ | 679,262 | 7,529,000 | 1.09% | ||
| 26 | TIVERTON ASSET MANAGEMENT LLC | 556,800 | 6,175,000 | 0.89% | ||
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 519,096 | 5,757,000 | 0.83% | ||
| 28 | EVENTIDE ASSET MANAGEMENT, LLC | 482,500 | 5,351,000 | 0.77% | ||
| 29 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 461,620 | 5,119,000 | 0.74% | ||
| 30 | APEX CAPITAL, LLC | 439,900 | 4,878,000 | 0.70% | ||
| 31 | JANUS HENDERSON INVESTORS US LLC | 437,864 | 4,856,000 | 0.70% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 430,676 | 4,776,000 | 0.69% | ||
| 33 | CREDIT SUISSE AG/ | 412,936 | 4,580,000 | 0.66% | ||
| 34 | WELLINGTON MANAGEMENT GROUP LLP | 411,580 | 4,565,000 | 0.66% | ||
| 35 | TEACHERS ADVISORS, LLC | 408,252 | 4,528,000 | 0.65% | ||
| 36 | MORGAN STANLEY | 399,704 | 4,433,000 | 0.64% | ||
| 37 | Cormorant Asset Management, LP | 361,000 | 4,003,000 | 0.58% | ||
| 38 | ALTRINSIC GLOBAL ADVISORS LLC | 340,000 | 3,771,000 | 0.54% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 334,396 | 3,708,000 | 0.54% | ||
| 40 | SABBY MANAGEMENT, LLC | 323,390 | 3,586,000 | 0.52% | ||
| 41 | Point72 Asset Management, L.P. | 320,300 | 3,552,000 | 0.51% | ||
| 42 | Numeric Investors LLC | 301,550 | 3,344,000 | 0.48% | ||
| 43 | BlackRock Investment Management, LLC | 234,428 | 2,600,000 | 0.38% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 226,000 | 2,506,000 | 0.36% | Put | |
| 45 | CITY NATIONAL BANK | 221,807 | 2,460,000 | 0.36% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 216,149 | 2,398,000 | 0.35% | ||
| 47 | FIL Ltd | 211,121 | 2,341,000 | 0.34% | ||
| 48 | SUFFOLK CAPITAL MANAGEMENT LLC | 197,000 | 2,185,000 | 0.32% | ||
| 49 | D. E. Shaw & Co., Inc. | 187,879 | 2,084,000 | 0.30% | ||
| 50 | OXFORD ASSET MANAGEMENT LLP | 177,308 | 1,966,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
