| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 6,000,000 | 94,080,000 | 9.28% | Call | |
| 2 | FMR LLC | 4,220,681 | 66,180,000 | 6.52% | ||
| 3 | GOLDMAN SACHS GROUP INC | 3,880,000 | 60,838,000 | 6.00% | Call | |
| 4 | WASATCH ADVISORS LP | 3,060,587 | 47,990,000 | 4.73% | ||
| 5 | BlackRock Fund Advisors | 2,605,701 | 40,857,000 | 4.03% | ||
| 6 | STATE STREET CORP | 2,517,383 | 39,472,000 | 3.89% | ||
| 7 | VANGUARD GROUP INC | 2,259,797 | 35,434,000 | 3.49% | ||
| 8 | FRONTIER CAPITAL MANAGEMENT CO LLC | 2,166,975 | 33,978,000 | 3.35% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,913,266 | 30,000,000 | 2.96% | ||
| 10 | Bank of New York Mellon Corp | 1,774,071 | 27,818,000 | 2.74% | ||
| 11 | JANUS HENDERSON INVESTORS US LLC | 1,755,818 | 27,531,000 | 2.71% | ||
| 12 | JENNISON ASSOCIATES LLC | 1,717,922 | 26,937,000 | 2.66% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,504,800 | 23,595,000 | 2.33% | Call | |
| 14 | BAKER BROS. ADVISORS LP | 1,404,544 | 22,023,000 | 2.17% | ||
| 15 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,300,000 | 20,384,000 | 2.01% | ||
| 16 | RA CAPITAL MANAGEMENT, L.P. | 1,220,209 | 19,133,000 | 1.89% | ||
| 17 | GOLDMAN SACHS GROUP INC | 1,053,443 | 16,518,000 | 1.63% | ||
| 18 | Invesco Ltd. | 1,044,894 | 16,384,000 | 1.62% | ||
| 19 | EverPoint Asset Management, LLC | 950,000 | 14,896,000 | 1.47% | ||
| 20 | PERCEPTIVE ADVISORS LLC | 800,000 | 12,544,000 | 1.24% | ||
| 21 | NORTHERN TRUST CORP | 793,490 | 12,442,000 | 1.23% | ||
| 22 | FIC CAPITAL INC | 783,479 | 12,285,000 | 1.21% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 744,537 | 11,674,000 | 1.15% | ||
| 24 | VOYA INVESTMENT MANAGEMENT LLC | 733,174 | 11,496,000 | 1.13% | ||
| 25 | FRANKLIN RESOURCES INC | 716,300 | 11,232,000 | 1.11% | ||
| 26 | Tekla Capital Management LLC | 679,100 | 10,648,000 | 1.05% | ||
| 27 | Allianz Asset Management GmbH | 678,328 | 10,637,000 | 1.05% | ||
| 28 | CITY NATIONAL BANK | 640,914 | 10,050,000 | 0.99% | ||
| 29 | TIVERTON ASSET MANAGEMENT LLC | 606,800 | 9,514,000 | 0.94% | ||
| 30 | DEUTSCHE BANK AG\ | 580,721 | 9,102,000 | 0.90% | ||
| 31 | First Eagle Investment Management, LLC | 559,780 | 8,777,000 | 0.87% | ||
| 32 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 521,698 | 8,180,000 | 0.81% | ||
| 33 | EVENTIDE ASSET MANAGEMENT, LLC | 482,500 | 7,566,000 | 0.75% | ||
| 34 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 444,600 | 6,971,000 | 0.69% | ||
| 35 | Cormorant Asset Management, LP | 442,000 | 6,931,000 | 0.68% | ||
| 36 | COLUMBUS CIRCLE INVESTORS | 435,389 | 6,827,000 | 0.67% | ||
| 37 | MORGAN STANLEY | 432,484 | 6,781,000 | 0.67% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 411,127 | 6,445,000 | 0.64% | ||
| 39 | WELLINGTON MANAGEMENT GROUP LLP | 405,040 | 6,351,000 | 0.63% | ||
| 40 | TEACHERS ADVISORS, LLC | 403,607 | 6,329,000 | 0.62% | ||
| 41 | D. E. Shaw & Co., Inc. | 400,883 | 6,286,000 | 0.62% | ||
| 42 | APEX CAPITAL, LLC | 400,000 | 6,272,000 | 0.62% | ||
| 43 | STIFEL FINANCIAL CORP | 397,743 | 6,234,000 | 0.61% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 365,068 | 5,724,000 | 0.56% | ||
| 45 | ALTRINSIC GLOBAL ADVISORS LLC | 340,000 | 5,331,000 | 0.53% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 336,400 | 5,275,000 | 0.52% | Put | |
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 327,709 | 5,139,000 | 0.51% | ||
| 48 | CREDIT SUISSE AG/ | 326,795 | 5,125,000 | 0.51% | ||
| 49 | Asset Management One Co., Ltd. | 270,868 | 4,295,000 | 0.42% | ||
| 50 | FIL Ltd | 266,418 | 4,177,000 | 0.41% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
