| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WASATCH ADVISORS LP | 7,256,260 | 22,132,000 | 17.27% | ||
| 2 | BAKER BROS. ADVISORS LP | 4,055,876 | 12,370,000 | 9.65% | ||
| 3 | BlackRock Fund Advisors | 3,215,835 | 9,808,000 | 7.65% | ||
| 4 | VANGUARD GROUP INC | 2,848,106 | 8,686,000 | 6.78% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,500,000 | 7,625,000 | 5.95% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 1,847,789 | 5,636,000 | 4.40% | ||
| 7 | FMR LLC | 1,703,783 | 5,197,000 | 4.05% | ||
| 8 | STATE STREET CORP | 1,186,569 | 3,614,000 | 2.82% | ||
| 9 | NORTHERN TRUST CORP | 892,776 | 2,723,000 | 2.12% | ||
| 10 | FIC CAPITAL INC | 875,284 | 2,670,000 | 2.08% | ||
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 837,963 | 2,556,000 | 1.99% | ||
| 12 | ROYCE & ASSOCIATES LP | 751,100 | 2,291,000 | 1.79% | ||
| 13 | ORBIMED ADVISORS LLC | 707,400 | 2,158,000 | 1.68% | ||
| 14 | DEUTSCHE BANK AG\ | 668,176 | 2,037,000 | 1.59% | ||
| 15 | Cormorant Asset Management, LP | 650,000 | 1,983,000 | 1.55% | ||
| 16 | ALTRINSIC GLOBAL ADVISORS LLC | 630,000 | 1,922,000 | 1.50% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 614,633 | 1,874,000 | 1.46% | ||
| 18 | FRONTIER CAPITAL MANAGEMENT CO LLC | 509,132 | 1,553,000 | 1.21% | ||
| 19 | NEXTHERA CAPITAL LP | 503,000 | 1,534,000 | 1.20% | ||
| 20 | COLUMBUS CIRCLE INVESTORS | 440,428 | 1,343,000 | 1.05% | ||
| 21 | MORGAN STANLEY | 414,550 | 1,264,000 | 0.99% | ||
| 22 | Opaleye Management Inc. | 400,000 | 1,220,000 | 0.95% | ||
| 23 | CREDIT SUISSE AG/ | 372,768 | 1,137,000 | 0.89% | ||
| 24 | D. E. Shaw & Co., Inc. | 360,038 | 1,098,000 | 0.86% | ||
| 25 | RENAISSANCE TECHNOLOGIES LLC | 321,819 | 982,000 | 0.77% | ||
| 26 | Bank of New York Mellon Corp | 314,163 | 958,000 | 0.75% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 287,541 | 877,000 | 0.68% | ||
| 28 | BlackRock Investment Management, LLC | 277,184 | 845,000 | 0.66% | ||
| 29 | WELLS FARGO & COMPANY/MN | 261,642 | 798,000 | 0.62% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 251,713 | 768,000 | 0.60% | ||
| 31 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 247,665 | 755,000 | 0.59% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 239,994 | 732,000 | 0.57% | ||
| 33 | Granahan Investment Management, LLC | 238,351 | 727,000 | 0.57% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 234,363 | 715,000 | 0.56% | ||
| 35 | BLACKROCK ADVISORS LLC | 213,766 | 652,000 | 0.51% | ||
| 36 | Candriam S.C.A. | 200,000 | 610,000 | 0.48% | ||
| 37 | GROUP ONE TRADING LLC | 188,580 | 575,000 | 0.45% | ||
| 38 | GOLDMAN SACHS GROUP INC | 174,455 | 532,000 | 0.42% | ||
| 39 | Piermont Capital Management Inc. | 165,569 | 505,000 | 0.39% | ||
| 40 | TEACHERS ADVISORS, LLC | 164,728 | 502,000 | 0.39% | ||
| 41 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 134,622 | 498,000 | 0.39% | ||
| 42 | QS Investors, LLC | 145,236 | 443,000 | 0.35% | ||
| 43 | PRICE T ROWE ASSOCIATES INC /MD/ | 143,200 | 437,000 | 0.34% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 142,881 | 436,000 | 0.34% | ||
| 45 | KEYBANK NATIONAL ASSOCIATION/OH | 135,247 | 413,000 | 0.32% | ||
| 46 | DIMENSIONAL FUND ADVISORS LP | 128,251 | 391,000 | 0.31% | ||
| 47 | CITADEL ADVISORS LLC | 119,700 | 365,000 | 0.28% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 119,300 | 364,000 | 0.28% | ||
| 49 | Swiss National Bank | 113,560 | 346,000 | 0.27% | ||
| 50 | SICART ASSOCIATES LLC | 101,950 | 311,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
