| 1 |
Essex Woodlands Management, Inc. |
3,813,197 |
69,362,000 |
31.43% |
|
|
| 2 |
SV Health Investors, LLC |
3,489,533 |
63,475,000 |
28.76% |
|
|
| 3 |
FMR LLC |
898,400 |
16,342,000 |
7.41% |
|
|
| 4 |
WELLS FARGO & COMPANY/MN |
497,929 |
9,057,000 |
4.10% |
|
|
| 5 |
Murphy Michael R |
482,137 |
8,770,000 |
3.97% |
|
|
| 6 |
First Light Asset Management, LLC |
397,141 |
7,224,000 |
3.27% |
|
|
| 7 |
Cortina Asset Management, LLC |
303,152 |
5,514,000 |
2.50% |
|
|
| 8 |
PRICE T ROWE ASSOCIATES INC /MD/ |
262,282 |
4,771,000 |
2.16% |
|
|
| 9 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
225,280 |
4,098,000 |
1.86% |
|
|
| 10 |
VANGUARD GROUP INC |
204,863 |
3,727,000 |
1.69% |
|
|
| 11 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
200,000 |
3,638,000 |
1.65% |
|
|
| 12 |
SECTORAL ASSET MANAGEMENT INC |
149,665 |
2,722,000 |
1.23% |
|
|
| 13 |
BlackRock Fund Advisors |
139,522 |
2,538,000 |
1.15% |
|
|
| 14 |
WASATCH ADVISORS LP |
141,557 |
2,467,000 |
1.12% |
|
|
| 15 |
Ghost Tree Capital, LLC |
110,000 |
2,001,000 |
0.91% |
|
|
| 16 |
FEDERATED HERMES, INC. |
103,100 |
1,875,000 |
0.85% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
92,974 |
1,691,000 |
0.77% |
|
|
| 18 |
AMERIPRISE FINANCIAL INC |
73,436 |
1,336,000 |
0.61% |
|
|
| 19 |
NORTHERN TRUST CORP |
60,710 |
1,105,000 |
0.50% |
|
|
| 20 |
Granite Investment Partners, LLC |
58,963 |
1,072,000 |
0.49% |
|
|
| 21 |
STATE STREET CORP |
50,773 |
923,000 |
0.42% |
|
|
| 22 |
PUTNAM INVESTMENTS LLC |
48,175 |
876,000 |
0.40% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
41,648 |
757,000 |
0.34% |
|
|
| 24 |
FRIESS ASSOCIATES LLC |
34,500 |
628,000 |
0.28% |
|
|
| 25 |
D. E. Shaw & Co., Inc. |
27,118 |
493,000 |
0.22% |
|
|
| 26 |
Bank of New York Mellon Corp |
25,347 |
461,000 |
0.21% |
|
|
| 27 |
Spark Investment Management LLC |
24,200 |
440,000 |
0.20% |
|
|
| 28 |
BlackRock Investment Management, LLC |
20,251 |
368,000 |
0.17% |
|
|
| 29 |
KEYBANK NATIONAL ASSOCIATION/OH |
19,481 |
354,000 |
0.16% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
18,669 |
340,000 |
0.15% |
|
|
| 31 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
16,815 |
306,000 |
0.14% |
|
|
| 32 |
Freedom Investment Management, Inc. |
16,456 |
299,000 |
0.14% |
|
|
| 33 |
KOPP INVESTMENT ADVISORS LLC |
12,403 |
226,000 |
0.10% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
11,557 |
210,000 |
0.10% |
|
|
| 35 |
RENAISSANCE TECHNOLOGIES LLC |
11,400 |
207,000 |
0.09% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
8,657 |
157,000 |
0.07% |
|
|
| 37 |
Swiss National Bank |
8,900 |
155,000 |
0.07% |
|
|
| 38 |
Grandeur Peak Global Advisors, LLC |
6,900 |
126,000 |
0.06% |
|
|
| 39 |
NEW YORK STATE COMMON RETIREMENT FUND |
4,900 |
89,000 |
0.04% |
|
|
| 40 |
CITIGROUP INC |
3,823 |
70,000 |
0.03% |
|
|
| 41 |
Nationwide Fund Advisors |
3,538 |
64,000 |
0.03% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,163 |
58,000 |
0.03% |
|
|
| 43 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
3,072 |
54,000 |
0.02% |
|
|
| 44 |
MORGAN STANLEY |
2,331 |
43,000 |
0.02% |
|
|
| 45 |
BlackRock Group LTD |
2,036 |
37,000 |
0.02% |
|
|
| 46 |
BLACKROCK ADVISORS LLC |
1,558 |
28,000 |
0.01% |
|
|
| 47 |
DEUTSCHE BANK AG\ |
1,403 |
24,000 |
0.01% |
|
|
| 48 |
BANK OF AMERICA CORP /DE/ |
1,122 |
20,000 |
0.01% |
|
|
| 49 |
UBS Group AG |
1,025 |
19,000 |
0.01% |
|
|
| 50 |
TEACHER RETIREMENT SYSTEM OF TEXAS |
808 |
15,000 |
0.01% |
|
|
