| 1 |
Essex Woodlands Management, Inc. |
3,813,197 |
98,647,000 |
32.54% |
|
|
| 2 |
SV Health Investors, LLC |
3,489,533 |
90,274,000 |
29.78% |
|
|
| 3 |
FMR LLC |
1,259,876 |
32,593,000 |
10.75% |
|
|
| 4 |
RS INVESTMENT MANAGEMENT CO LLC |
836,046 |
21,629,000 |
7.13% |
|
|
| 5 |
LORD, ABBETT & CO. LLC |
278,117 |
7,195,000 |
2.37% |
|
|
| 6 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
265,000 |
6,856,000 |
2.26% |
|
|
| 7 |
WELLS FARGO & COMPANY/MN |
249,836 |
6,463,000 |
2.13% |
|
|
| 8 |
PRICE T ROWE ASSOCIATES INC /MD/ |
219,869 |
5,688,000 |
1.88% |
|
|
| 9 |
NEXT CENTURY GROWTH INVESTORS LLC |
150,818 |
3,901,000 |
1.29% |
|
|
| 10 |
BlackRock Fund Advisors |
144,756 |
3,745,000 |
1.24% |
|
|
| 11 |
AMERICAN CENTURY COMPANIES INC |
120,405 |
3,115,000 |
1.03% |
|
|
| 12 |
VANGUARD GROUP INC |
108,754 |
2,814,000 |
0.93% |
|
|
| 13 |
WASATCH ADVISORS LP |
96,577 |
2,498,000 |
0.82% |
|
|
| 14 |
WADDELL & REED FINANCIAL INC |
87,700 |
2,269,000 |
0.75% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
57,820 |
1,496,000 |
0.49% |
|
|
| 16 |
FEDERATED HERMES, INC. |
57,757 |
1,494,000 |
0.49% |
|
|
| 17 |
NORTHERN TRUST CORP |
52,603 |
1,361,000 |
0.45% |
|
|
| 18 |
PUTNAM INVESTMENTS LLC |
46,356 |
1,199,000 |
0.40% |
|
|
| 19 |
STATE STREET CORP |
44,676 |
1,157,000 |
0.38% |
|
|
| 20 |
WALL STREET ASSOCIATES |
40,000 |
1,035,000 |
0.34% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
35,139 |
909,000 |
0.30% |
|
|
| 22 |
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
26,142 |
676,000 |
0.22% |
|
|
| 23 |
AMERIPRISE FINANCIAL INC |
25,800 |
667,000 |
0.22% |
|
|
| 24 |
Bank of New York Mellon Corp |
24,397 |
631,000 |
0.21% |
|
|
| 25 |
BlackRock Investment Management, LLC |
20,447 |
529,000 |
0.17% |
|
|
| 26 |
BELLEVUE ASSET MANAGEMENT AG |
20,000 |
517,000 |
0.17% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
18,669 |
483,000 |
0.16% |
|
|
| 28 |
D. E. Shaw & Co., Inc. |
17,400 |
450,000 |
0.15% |
|
|
| 29 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
15,302 |
396,000 |
0.13% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
15,290 |
396,000 |
0.13% |
|
|
| 31 |
KEYBANK NATIONAL ASSOCIATION/OH |
10,105 |
261,000 |
0.09% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,870 |
255,000 |
0.08% |
|
|
| 33 |
GSA CAPITAL PARTNERS LLP |
8,900 |
230,000 |
0.08% |
|
|
| 34 |
TEACHERS ADVISORS, LLC |
8,657 |
224,000 |
0.07% |
|
|
| 35 |
BLAIR WILLIAM & CO/IL |
8,050 |
208,000 |
0.07% |
|
|
| 36 |
Swiss National Bank |
5,800 |
150,000 |
0.05% |
|
|
| 37 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,763 |
149,000 |
0.05% |
|
|
| 38 |
Nationwide Fund Advisors |
3,538 |
92,000 |
0.03% |
|
|
| 39 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,166 |
81,904 |
0.03% |
|
|
| 40 |
BANK OF AMERICA CORP /DE/ |
2,946 |
76,000 |
0.03% |
|
|
| 41 |
BLACKROCK ADVISORS LLC |
2,877 |
74,000 |
0.02% |
|
|
| 42 |
MORGAN STANLEY |
2,646 |
69,000 |
0.02% |
|
|
| 43 |
DEUTSCHE BANK AG\ |
1,326 |
34,000 |
0.01% |
|
|
| 44 |
BARCLAYS PLC |
1,303 |
33,000 |
0.01% |
|
|
| 45 |
UBS Group AG |
1,100 |
28,000 |
0.01% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
617 |
16,000 |
0.01% |
|
|
| 47 |
ROYAL BANK OF CANADA |
588 |
15,000 |
0.00% |
|
|
| 48 |
BlackRock Japan Co. Ltd |
488 |
13,000 |
0.00% |
|
|
| 49 |
SECTORAL ASSET MANAGEMENT INC |
505 |
13,000 |
0.00% |
|
|
| 50 |
BNP PARIBAS FINANCIAL MARKETS |
450 |
11,642 |
0.00% |
|
|
