| 1 |
Essex Woodlands Management, Inc. |
3,813,197 |
72,336,000 |
27.90% |
|
|
| 2 |
SV Health Investors, LLC |
3,489,533 |
66,198,000 |
25.53% |
|
|
| 3 |
DISCOVERY GROUP I, LLC |
745,983 |
14,151,000 |
5.46% |
|
|
| 4 |
FMR LLC |
705,700 |
13,387,000 |
5.16% |
|
|
| 5 |
INTERNATIONAL BIOTECHNOLOGY TRUST PLC |
403,320 |
7,631,000 |
2.94% |
|
|
| 6 |
First Light Asset Management, LLC |
391,289 |
7,423,000 |
2.86% |
|
|
| 7 |
WELLS FARGO & COMPANY/MN |
379,535 |
7,200,000 |
2.78% |
|
|
| 8 |
Cortina Asset Management, LLC |
336,444 |
6,382,000 |
2.46% |
|
|
| 9 |
PRICE T ROWE ASSOCIATES INC /MD/ |
327,233 |
6,208,000 |
2.39% |
|
|
| 10 |
ArrowMark Colorado Holdings LLC |
312,634 |
5,931,000 |
2.29% |
|
|
| 11 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
250,756 |
4,757,000 |
1.83% |
|
|
| 12 |
BlackRock Fund Advisors |
247,066 |
4,687,000 |
1.81% |
|
|
| 13 |
VANGUARD GROUP INC |
238,990 |
4,533,000 |
1.75% |
|
|
| 14 |
FEDERATED HERMES, INC. |
220,100 |
4,175,000 |
1.61% |
|
|
| 15 |
Ghost Tree Capital, LLC |
200,000 |
3,794,000 |
1.46% |
|
|
| 16 |
WASATCH ADVISORS LP |
199,717 |
3,789,000 |
1.46% |
|
|
| 17 |
SECTORAL ASSET MANAGEMENT INC |
130,496 |
2,476,000 |
0.96% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
119,847 |
2,273,000 |
0.88% |
|
|
| 19 |
NEXT CENTURY GROWTH INVESTORS LLC |
109,738 |
2,081,000 |
0.80% |
|
|
| 20 |
WADDELL & REED FINANCIAL INC |
108,977 |
2,067,000 |
0.80% |
|
|
| 21 |
STATE STREET CORP |
105,783 |
2,007,000 |
0.77% |
|
|
| 22 |
NORTHERN TRUST CORP |
99,587 |
1,889,000 |
0.73% |
|
|
| 23 |
RENAISSANCE TECHNOLOGIES LLC |
78,800 |
1,495,000 |
0.58% |
|
|
| 24 |
Millrace Asset Group, Inc. |
66,000 |
1,252,000 |
0.48% |
|
|
| 25 |
PERKINS CAPITAL MANAGEMENT INC |
56,350 |
1,069,000 |
0.41% |
|
|
| 26 |
AMERIPRISE FINANCIAL INC |
55,780 |
1,058,000 |
0.41% |
|
|
| 27 |
GEODE CAPITAL MANAGEMENT, LLC |
52,107 |
988,000 |
0.38% |
|
|
| 28 |
ROYCE & ASSOCIATES LP |
43,000 |
816,000 |
0.31% |
|
|
| 29 |
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
34,946 |
663,000 |
0.26% |
|
|
| 30 |
Bank of New York Mellon Corp |
32,323 |
613,000 |
0.24% |
|
|
| 31 |
BlackRock Investment Management, LLC |
27,715 |
526,000 |
0.20% |
|
|
| 32 |
Freedom Investment Management, Inc. |
27,252 |
517,000 |
0.20% |
|
|
| 33 |
KEYBANK NATIONAL ASSOCIATION/OH |
24,638 |
467,000 |
0.18% |
|
|
| 34 |
MORGAN STANLEY |
21,966 |
417,000 |
0.16% |
|
|
| 35 |
Grandeur Peak Global Advisors, LLC |
21,950 |
416,000 |
0.16% |
|
|
| 36 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
20,577 |
390,000 |
0.15% |
|
|
| 37 |
PUTNAM INVESTMENTS LLC |
20,488 |
388,000 |
0.15% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
18,475 |
351,000 |
0.14% |
|
|
| 39 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
15,417 |
292,000 |
0.11% |
|
|
| 40 |
Quinn Opportunity Partners LLC |
12,700 |
241,000 |
0.09% |
|
|
| 41 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
11,775 |
223,000 |
0.09% |
|
|
| 42 |
TEACHERS ADVISORS, LLC |
10,533 |
200,000 |
0.08% |
|
|
| 43 |
NEW YORK STATE COMMON RETIREMENT FUND |
10,400 |
197,000 |
0.08% |
|
|
| 44 |
JPMORGAN CHASE & CO |
10,403 |
197,000 |
0.08% |
|
|
| 45 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
10,315 |
196,000 |
0.08% |
|
|
| 46 |
Swiss National Bank |
8,900 |
169,000 |
0.07% |
|
|
| 47 |
CITIGROUP INC |
5,111 |
97,000 |
0.04% |
|
|
| 48 |
BANK OF AMERICA CORP /DE/ |
4,824 |
92,000 |
0.04% |
|
|
| 49 |
Nationwide Fund Advisors |
4,842 |
92,000 |
0.04% |
|
|
| 50 |
DEUTSCHE BANK AG\ |
4,477 |
84,000 |
0.03% |
|
|
