| 1 |
Essex Woodlands Management, Inc. |
3,813,197 |
69,667,000 |
30.56% |
|
|
| 2 |
SV Health Investors, LLC |
3,489,533 |
63,754,000 |
27.97% |
|
|
| 3 |
FMR LLC |
716,700 |
13,094,000 |
5.74% |
|
|
| 4 |
Murphy Michael R |
627,441 |
11,463,000 |
5.03% |
|
|
| 5 |
WELLS FARGO & COMPANY/MN |
496,665 |
9,074,000 |
3.98% |
|
|
| 6 |
Cortina Asset Management, LLC |
421,897 |
7,708,000 |
3.38% |
|
|
| 7 |
First Light Asset Management, LLC |
396,291 |
7,240,000 |
3.18% |
|
|
| 8 |
PRICE T ROWE ASSOCIATES INC /MD/ |
327,282 |
5,979,000 |
2.62% |
|
|
| 9 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
225,280 |
4,116,000 |
1.81% |
|
|
| 10 |
FEDERATED HERMES, INC. |
220,100 |
4,021,000 |
1.76% |
|
|
| 11 |
VANGUARD GROUP INC |
215,395 |
3,936,000 |
1.73% |
|
|
| 12 |
BlackRock Fund Advisors |
195,518 |
3,572,000 |
1.57% |
|
|
| 13 |
WASATCH ADVISORS LP |
181,581 |
3,317,000 |
1.46% |
|
|
| 14 |
SECTORAL ASSET MANAGEMENT INC |
146,006 |
2,668,000 |
1.17% |
|
|
| 15 |
Ghost Tree Capital, LLC |
120,000 |
2,192,000 |
0.96% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
108,325 |
1,979,000 |
0.87% |
|
|
| 17 |
STATE STREET CORP |
96,040 |
1,753,000 |
0.77% |
|
|
| 18 |
NORTHERN TRUST CORP |
93,981 |
1,717,000 |
0.75% |
|
|
| 19 |
AMERIPRISE FINANCIAL INC |
75,048 |
1,370,000 |
0.60% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
47,675 |
871,000 |
0.38% |
|
|
| 21 |
PUTNAM INVESTMENTS LLC |
47,212 |
863,000 |
0.38% |
|
|
| 22 |
Spark Investment Management LLC |
42,900 |
783,000 |
0.34% |
|
|
| 23 |
FRIESS ASSOCIATES LLC |
34,500 |
630,000 |
0.28% |
|
|
| 24 |
RENAISSANCE TECHNOLOGIES LLC |
31,400 |
574,000 |
0.25% |
|
|
| 25 |
Bank of New York Mellon Corp |
30,307 |
554,000 |
0.24% |
|
|
| 26 |
BlackRock Investment Management, LLC |
27,481 |
502,000 |
0.22% |
|
|
| 27 |
D. E. Shaw & Co., Inc. |
27,226 |
497,000 |
0.22% |
|
|
| 28 |
Freedom Investment Management, Inc. |
26,368 |
482,000 |
0.21% |
|
|
| 29 |
PERKINS CAPITAL MANAGEMENT INC |
22,500 |
411,000 |
0.18% |
|
|
| 30 |
Grandeur Peak Global Advisors, LLC |
21,950 |
401,000 |
0.18% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
21,083 |
385,000 |
0.17% |
|
|
| 32 |
KEYBANK NATIONAL ASSOCIATION/OH |
19,481 |
356,000 |
0.16% |
|
|
| 33 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
17,025 |
312,000 |
0.14% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
15,717 |
287,000 |
0.13% |
|
|
| 35 |
KOPP INVESTMENT ADVISORS LLC |
11,778 |
215,000 |
0.09% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
10,533 |
192,000 |
0.08% |
|
|
| 37 |
NEW YORK STATE COMMON RETIREMENT FUND |
10,400 |
190,000 |
0.08% |
|
|
| 38 |
DEIMOS ASSET MANAGEMENT LLC |
10,000 |
183,000 |
0.08% |
|
|
| 39 |
Swiss National Bank |
8,900 |
163,000 |
0.07% |
|
|
| 40 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
6,652 |
122,000 |
0.05% |
|
|
| 41 |
Nationwide Fund Advisors |
4,842 |
88,000 |
0.04% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,315 |
78,835 |
0.03% |
|
|
| 43 |
BLACKROCK ADVISORS LLC |
2,166 |
40,000 |
0.02% |
|
|
| 44 |
BlackRock Group LTD |
2,036 |
37,000 |
0.02% |
|
|
| 45 |
DEUTSCHE BANK AG\ |
1,146 |
20,000 |
0.01% |
|
|
| 46 |
BANK OF AMERICA CORP /DE/ |
1,066 |
19,000 |
0.01% |
|
|
| 47 |
TEACHER RETIREMENT SYSTEM OF TEXAS |
922 |
17,000 |
0.01% |
|
|
| 48 |
ROYAL BANK OF CANADA |
700 |
13,000 |
0.01% |
|
|
| 49 |
UBS Group AG |
600 |
11,000 |
0.00% |
|
|
| 50 |
BlackRock Finance, Inc. |
346 |
6,000 |
0.00% |
|
|
