| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Devon Park Associates, LLC | 3,243,709 | 30,750,000 | 14.60% | ||
| 2 | RHO CAPITAL PARTNERS INC | 2,627,790 | 24,911,000 | 11.83% | ||
| 3 | JENNISON ASSOCIATES LLC | 1,976,152 | 18,734,000 | 8.90% | ||
| 4 | ORBIMED ADVISORS LLC | 1,849,300 | 17,531,000 | 8.33% | ||
| 5 | FRANKLIN RESOURCES INC | 1,343,059 | 12,732,000 | 6.05% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 939,081 | 8,902,000 | 4.23% | ||
| 7 | Point72 Asset Management, L.P. | 880,000 | 8,342,000 | 3.96% | ||
| 8 | BlackRock Fund Advisors | 835,508 | 7,921,000 | 3.76% | ||
| 9 | BLACKROCK ADVISORS LLC | 750,206 | 7,112,000 | 3.38% | ||
| 10 | VANGUARD GROUP INC | 616,656 | 5,846,000 | 2.78% | ||
| 11 | EverPoint Asset Management, LLC | 500,000 | 4,740,000 | 2.25% | ||
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 470,000 | 4,456,000 | 2.12% | ||
| 13 | SENZAR ASSET MANAGEMENT, LLC | 413,622 | 3,921,137 | 1.86% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 401,764 | 3,809,000 | 1.81% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 399,173 | 3,784,000 | 1.80% | ||
| 16 | GOLDMAN SACHS GROUP INC | 361,000 | 3,422,000 | 1.63% | Put | |
| 17 | MILLENNIUM MANAGEMENT LLC | 357,788 | 3,392,000 | 1.61% | ||
| 18 | GW&K Investment Management, LLC | 354,148 | 3,357,000 | 1.59% | ||
| 19 | BlackRock Group LTD | 339,407 | 3,218,000 | 1.53% | ||
| 20 | STATE STREET CORP | 256,586 | 2,429,000 | 1.15% | ||
| 21 | DAFNA Capital Management LLC | 237,235 | 2,249,000 | 1.07% | ||
| 22 | GOLDMAN SACHS GROUP INC | 215,110 | 2,039,000 | 0.97% | ||
| 23 | D. E. Shaw & Co., Inc. | 202,624 | 1,921,000 | 0.91% | ||
| 24 | NORTHERN TRUST CORP | 190,136 | 1,802,000 | 0.86% | ||
| 25 | Tekla Capital Management LLC | 180,762 | 1,714,000 | 0.81% | ||
| 26 | Ghost Tree Capital, LLC | 170,000 | 1,612,000 | 0.77% | ||
| 27 | COLUMBUS CIRCLE INVESTORS | 168,378 | 1,596,000 | 0.76% | ||
| 28 | FT OPTIONS LLC | 156,864 | 1,487,000 | 0.71% | ||
| 29 | SABBY MANAGEMENT, LLC | 144,002 | 1,365,000 | 0.65% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 124,962 | 1,184,000 | 0.56% | ||
| 31 | PURA VIDA INVESTMENTS, LLC | 111,468 | 1,057,000 | 0.50% | ||
| 32 | BlackRock Investment Management, LLC | 104,508 | 991,000 | 0.47% | ||
| 33 | GREAT POINT PARTNERS LLC | 94,077 | 892,000 | 0.42% | ||
| 34 | BlackRock Finance, Inc. | 81,496 | 773,000 | 0.37% | ||
| 35 | Polar Capital LLP | 75,000 | 711,000 | 0.34% | ||
| 36 | GRATICULE ASIA MACRO ADVISORS LLC | 66,517 | 631,000 | 0.30% | ||
| 37 | Bank of New York Mellon Corp | 63,764 | 605,000 | 0.29% | ||
| 38 | SHEPHERD KAPLAN KROCHUK, LLC | 57,344 | 544,000 | 0.26% | ||
| 39 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 54,813 | 520,000 | 0.25% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 50,792 | 482,000 | 0.23% | ||
| 41 | New Leaf Venture Partners, L.L.C. | 50,300 | 477,000 | 0.23% | ||
| 42 | BALYASNY ASSET MANAGEMENT L.P. | 50,000 | 474,000 | 0.23% | ||
| 43 | TD ASSET MANAGEMENT INC | 41,700 | 395,000 | 0.19% | ||
| 44 | C M BIDWELL & ASSOCIATES LTD | 38,415 | 364,000 | 0.17% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,899 | 350,000 | 0.17% | ||
| 46 | ALPS ADVISORS INC | 34,332 | 325,000 | 0.15% | ||
| 47 | PUTNAM INVESTMENTS LLC | 34,073 | 323,000 | 0.15% | ||
| 48 | DEUTSCHE BANK AG\ | 33,165 | 312,000 | 0.15% | ||
| 49 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 32,119 | 305,000 | 0.14% | ||
| 50 | DIMENSIONAL FUND ADVISORS LP | 30,598 | 290,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
