| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RHO CAPITAL PARTNERS INC | 2,627,790 | 16,030,000 | 13.48% | ||
| 2 | JENNISON ASSOCIATES LLC | 1,980,842 | 12,083,000 | 10.16% | ||
| 3 | ORBIMED ADVISORS LLC | 1,849,300 | 11,281,000 | 9.48% | ||
| 4 | GREAT POINT PARTNERS LLC | 1,500,000 | 9,150,000 | 7.69% | ||
| 5 | FRANKLIN RESOURCES INC | 1,319,459 | 8,049,000 | 6.77% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 945,781 | 5,769,000 | 4.85% | ||
| 7 | BlackRock Fund Advisors | 552,073 | 3,368,000 | 2.83% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 527,281 | 3,216,000 | 2.70% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 470,000 | 2,867,000 | 2.41% | ||
| 10 | SENZAR ASSET MANAGEMENT, LLC | 412,422 | 2,516,000 | 2.12% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 412,323 | 2,515,000 | 2.11% | ||
| 12 | VANGUARD GROUP INC | 411,222 | 2,508,000 | 2.11% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 401,764 | 2,451,000 | 2.06% | ||
| 14 | GOLDMAN SACHS GROUP INC | 376,627 | 2,297,000 | 1.93% | ||
| 15 | GOLDMAN SACHS GROUP INC | 361,000 | 2,202,000 | 1.85% | Put | |
| 16 | DLD ASSET MANAGEMENT, LP | 347,200 | 2,124,000 | 1.79% | Call | |
| 17 | Ghost Tree Capital, LLC | 300,000 | 1,830,000 | 1.54% | Call | |
| 18 | GW&K Investment Management, LLC | 298,937 | 1,824,000 | 1.53% | ||
| 19 | BLACKROCK ADVISORS LLC | 285,706 | 1,743,000 | 1.47% | ||
| 20 | STATE STREET CORP | 265,532 | 1,618,000 | 1.36% | ||
| 21 | DAFNA Capital Management LLC | 237,135 | 1,447,000 | 1.22% | ||
| 22 | EverPoint Asset Management, LLC | 235,726 | 1,438,000 | 1.21% | ||
| 23 | COLUMBUS CIRCLE INVESTORS | 215,967 | 1,317,000 | 1.11% | ||
| 24 | FT OPTIONS LLC | 181,172 | 1,105,000 | 0.93% | ||
| 25 | NORTHERN TRUST CORP | 180,217 | 1,099,000 | 0.92% | ||
| 26 | Parallax Volatility Advisers, L.P. | 162,900 | 994,000 | 0.84% | Call | |
| 27 | SABBY MANAGEMENT, LLC | 150,930 | 921,000 | 0.77% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 148,400 | 905,000 | 0.76% | Put | |
| 29 | BlackRock Group LTD | 146,607 | 894,000 | 0.75% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 130,819 | 797,000 | 0.67% | ||
| 31 | DLD ASSET MANAGEMENT, LP | 113,500 | 695,000 | 0.58% | Put | |
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 113,134 | 690,000 | 0.58% | ||
| 33 | D. E. Shaw & Co., Inc. | 103,428 | 631,000 | 0.53% | ||
| 34 | OXFORD ASSET MANAGEMENT LLP | 101,192 | 617,000 | 0.52% | ||
| 35 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 90,947 | 554,000 | 0.47% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 82,500 | 503,000 | 0.42% | Call | |
| 37 | BlackRock Investment Management, LLC | 80,392 | 490,000 | 0.41% | ||
| 38 | DUPONT CAPITAL MANAGEMENT CORP | 76,784 | 468,000 | 0.39% | ||
| 39 | BALYASNY ASSET MANAGEMENT L.P. | 72,100 | 440,000 | 0.37% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,900 | 439,000 | 0.37% | Call | |
| 41 | Bank of New York Mellon Corp | 68,891 | 420,000 | 0.35% | ||
| 42 | CUTLER GROUP LLC / CA | 68,029 | 414,000 | 0.35% | ||
| 43 | New Leaf Venture Partners, L.L.C. | 62,300 | 380,000 | 0.32% | ||
| 44 | MORGAN STANLEY | 59,619 | 363,000 | 0.31% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,923 | 341,000 | 0.29% | ||
| 46 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 54,813 | 334,000 | 0.28% | ||
| 47 | BlackRock Finance, Inc. | 44,096 | 269,000 | 0.23% | ||
| 48 | TD ASSET MANAGEMENT INC | 41,200 | 251,000 | 0.21% | ||
| 49 | SIMPLEX TRADING, LLC | 40,363 | 246,000 | 0.21% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,899 | 219,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
