| 1 |
BVF INC/IL |
6,171,669 |
29,315,000 |
26.12% |
|
|
| 2 |
NEA Management Company, LLC |
4,566,666 |
21,692,000 |
19.33% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
2,364,167 |
11,230,000 |
10.01% |
|
|
| 4 |
BlackRock Institutional Trust Company, N.A. |
1,332,449 |
6,329,000 |
5.64% |
|
|
| 5 |
VANGUARD GROUP INC |
1,002,790 |
4,763,000 |
4.24% |
|
|
| 6 |
BlackRock Fund Advisors |
787,464 |
3,740,000 |
3.33% |
|
|
| 7 |
JENNISON ASSOCIATES LLC |
699,398 |
3,322,000 |
2.96% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
617,000 |
2,931,000 |
2.61% |
|
|
| 9 |
D. E. Shaw & Co., Inc. |
575,580 |
2,734,000 |
2.44% |
|
|
| 10 |
DIMENSIONAL FUND ADVISORS LP |
537,093 |
2,551,000 |
2.27% |
|
|
| 11 |
STATE STREET CORP |
461,261 |
2,189,000 |
1.95% |
|
|
| 12 |
FMR LLC |
415,061 |
1,972,000 |
1.76% |
|
|
| 13 |
NORTHERN TRUST CORP |
354,405 |
1,683,000 |
1.50% |
|
|
| 14 |
Sarissa Capital Management LP |
329,516 |
1,565,000 |
1.39% |
|
|
| 15 |
TFS CAPITAL LLC |
296,888 |
1,410,000 |
1.26% |
|
|
| 16 |
Bank of New York Mellon Corp |
235,086 |
1,117,000 |
1.00% |
|
|
| 17 |
PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC |
202,400 |
961,000 |
0.86% |
Call |
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
199,700 |
949,000 |
0.85% |
Call |
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
193,922 |
921,000 |
0.82% |
|
|
| 20 |
GOLDMAN SACHS GROUP INC |
176,286 |
837,000 |
0.75% |
|
|
| 21 |
DEUTSCHE BANK AG\ |
161,581 |
767,000 |
0.68% |
|
|
| 22 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
143,300 |
681,000 |
0.61% |
|
|
| 23 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
130,779 |
621,000 |
0.55% |
|
|
| 24 |
TWO SIGMA ADVISERS, LP |
121,421 |
576,000 |
0.51% |
|
|
| 25 |
MORGAN STANLEY |
114,987 |
546,000 |
0.49% |
|
|
| 26 |
Arbor Investment Advisors, LLC |
104,260 |
495,000 |
0.44% |
|
|
| 27 |
BlackRock Investment Management, LLC |
97,091 |
461,000 |
0.41% |
|
|
| 28 |
LOS ANGELES CAPITAL MANAGEMENT LLC |
96,070 |
456,000 |
0.41% |
|
|
| 29 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
82,100 |
369,000 |
0.33% |
|
|
| 30 |
Connor, Clark & Lunn Investment Management Ltd. |
69,100 |
362,000 |
0.32% |
|
|
| 31 |
BARCLAYS PLC |
82,196 |
328,000 |
0.29% |
|
|
| 32 |
TWO SIGMA INVESTMENTS, LP |
63,454 |
302,000 |
0.27% |
|
|
| 33 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
50,389 |
239,000 |
0.21% |
|
|
| 34 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
47,838 |
227,000 |
0.20% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
47,329 |
225,000 |
0.20% |
|
|
| 36 |
Invesco Ltd. |
41,820 |
199,000 |
0.18% |
|
|
| 37 |
PANAGORA ASSET MANAGEMENT INC |
39,310 |
186,000 |
0.17% |
|
|
| 38 |
OAK ASSOCIATES LTD /OH/ |
38,456 |
183,000 |
0.16% |
|
|
| 39 |
RHUMBLINE ADVISERS |
37,473 |
178,000 |
0.16% |
|
|
| 40 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
37,100 |
177,000 |
0.16% |
|
|
| 41 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
35,324 |
168,000 |
0.15% |
|
|
| 42 |
VIRGINIA RETIREMENT SYSTEMS ET Al |
33,400 |
159,000 |
0.14% |
|
|
| 43 |
A.R.T. Advisors, LLC |
33,317 |
158,000 |
0.14% |
|
|
| 44 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
32,000 |
152,000 |
0.14% |
|
|
| 45 |
Nationwide Fund Advisors |
30,382 |
144,000 |
0.13% |
|
|
| 46 |
ProShare Advisors LLC |
28,229 |
134,000 |
0.12% |
|
|
| 47 |
GROUP ONE TRADING LLC |
25,860 |
123,000 |
0.11% |
|
|
| 48 |
CREDIT SUISSE AG/ |
24,622 |
116,000 |
0.10% |
|
|
| 49 |
ALLIANCEBERNSTEIN L.P. |
24,100 |
114,000 |
0.10% |
|
|
| 50 |
MILLENNIUM MANAGEMENT LLC |
23,225 |
110,000 |
0.10% |
|
|
